CD25+ regulatory T cells and tumor immunity.

Abstract:

:Tumor cells express a range of antigens including self-antigens (those whose expression is shared by normal host tissue) and non-self antigens (such as those that arise as a result of mutations in normal cellular genes or in the case of some tumors, viral antigens). Immune responses to both types of antigen have been identified in human patients with cancer and in murine tumor models. In both cases, these responses are typically weak and generally fail to result in tumor rejection. Accumulating evidence indicates that a population of T cells, namely CD25(+) regulatory cells, is at least partly responsible for the poor immunogenicity of tumor cells. This evidence is discussed in the context of a murine model of melanoma.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Jones E,Dahm-Vicker M,Golgher D,Gallimore A

doi

10.1016/s0165-2478(02)00240-7

subject

Has Abstract

pub_date

2003-01-22 00:00:00

pages

141-3

issue

2

eissn

0165-2478

issn

1879-0542

pii

S0165247802002407

journal_volume

85

pub_type

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