Abstract:
:Tumor cells express a range of antigens including self-antigens (those whose expression is shared by normal host tissue) and non-self antigens (such as those that arise as a result of mutations in normal cellular genes or in the case of some tumors, viral antigens). Immune responses to both types of antigen have been identified in human patients with cancer and in murine tumor models. In both cases, these responses are typically weak and generally fail to result in tumor rejection. Accumulating evidence indicates that a population of T cells, namely CD25(+) regulatory cells, is at least partly responsible for the poor immunogenicity of tumor cells. This evidence is discussed in the context of a murine model of melanoma.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Jones E,Dahm-Vicker M,Golgher D,Gallimore Adoi
10.1016/s0165-2478(02)00240-7subject
Has Abstractpub_date
2003-01-22 00:00:00pages
141-3issue
2eissn
0165-2478issn
1879-0542pii
S0165247802002407journal_volume
85pub_type
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更新日期:2014-09-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00