Abstract:
:Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory processes, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) or immune processes including autoantibodies, such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA). After the discovery of RF, the recent recognition of various autoantibodies against post-translationally modified proteins opened new avenues to diagnosing RA and predicting the course of the disease. Citrullination and carbamylation of amino acids generate new epitopes that can potentially promote the production of novel autoantibodies. In spite of growing knowledge, the pathogenic role of these autoantibodies is still not fully elucidated in RA. In this paper, we review the currently available and novel promising immune biomarkers, which may help in early diagnosis and estimating prognosis in RA.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Nakken B,Papp G,Bosnes V,Zeher M,Nagy G,Szodoray Pdoi
10.1016/j.imlet.2017.05.010subject
Has Abstractpub_date
2017-09-01 00:00:00pages
13-18eissn
0165-2478issn
1879-0542pii
S0165-2478(17)30207-9journal_volume
189pub_type
杂志文章,评审abstract::The antischistosomal property of a short course of cyclosporin A (CsA), administered at the time of infection was demonstrated in the rat. In comparison with vehicle-treated controls, no schistosomes were recovered from CsA-treated animals, 18-19 days post infection. Flow cytometric analysis of blood and spleen lympho...
journal_title:Immunology letters
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doi:10.1016/0165-2478(88)90086-7
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90039-4
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00314-x
更新日期:2001-02-01 00:00:00
abstract::Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.02.008
更新日期:2017-04-01 00:00:00
abstract::Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90090-7
更新日期:1984-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90056-7
更新日期:1984-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.09.007
更新日期:2015-02-01 00:00:00
abstract::Immunoglobulin species, recombined from Fab and Fc fragments with anti-red cell specificity were used as cytophilic antibodies in studies of triggering the effector activity of immunoglobulins. Recombinant immunoglobulins containing a single Fab' appeared inactive in binding to cell receptors and triggering antibody d...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90046-4
更新日期:1984-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00039-1
更新日期:2002-05-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90048-f
更新日期:1991-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(99)00024-3
更新日期:1999-05-03 00:00:00
abstract::The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90021-4
更新日期:1983-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90095-x
更新日期:1981-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90036-6
更新日期:1983-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.07.010
更新日期:2006-11-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00091-6
更新日期:1997-10-01 00:00:00
abstract::Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.03.020
更新日期:2005-09-15 00:00:00
abstract::The binding of anti-IgM IgG to human monoclonal IgM has been studied calorimetrically and results have been compared with parallel turbidity measurements of the same reaction. In the first series of experiments using the flow calorimeter equipped with a mixing cell, varied flow rates gave identical values for the ther...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90091-9
更新日期:1984-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00184-x
更新日期:2000-06-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2003.11.025
更新日期:2004-03-29 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02522-9
更新日期:1996-05-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.015
更新日期:2014-12-01 00:00:00
abstract::Adoptive transfer of multivirus-specific T cell lines (MVST) is an advanced tool for immunotherapy of virus infections after hematopoietic stem cell transplantation (HSCT). Their preparation includes activation of donor virus-specific T cells by the mixture of oligopeptides derived from immunodominant antigens of seve...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.09.009
更新日期:2020-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.02.012
更新日期:2020-06-01 00:00:00
abstract::An effective HIV vaccine will likely need to induce potent and broad-based immunity, including CD8+ T cell responses. Hence, a quantitative assay to measure such responses in animal models will be important in the evaluation of candidate HIV vaccines. We show here that a single immunization with HIV DNA vaccines, foll...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00237-7
更新日期:2003-01-22 00:00:00
abstract::The induction of antigen (Ag)-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. Recently, attention has been focused on induction of active suppression by regulatory T cells (Treg cells). Also, a role for dendritic cells (DCs) in the promotion of peripheral tolera...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2004.04.015
更新日期:2004-06-15 00:00:00
abstract::Culture of high density resting murine B cells with recombinant IL-4 caused changes in the patterns of phosphoproteins associated with the plasma membranes isolated from such cells. The principal difference was the appearance of an alkali-resistant phosphoprotein of Mr = 75,000-80,000. Culture with LPS also gave rise ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90195-8
更新日期:1989-09-01 00:00:00
abstract::Sequence-comparison indicates existing sequence-similarity between receptor-binding regions of human type 1 IFNs (IFN-alpha, -beta and -omega) and HIV-1 gp41. Previous findings had suggested that the increased levels of antibodies against human IFN-alpha and -beta in HIV-1-infected individuals are associated with a co...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00098-x
更新日期:1999-08-03 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90086-1
更新日期:1987-01-01 00:00:00
abstract::The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90090-b
更新日期:1992-06-01 00:00:00