Abstract：
:It is known that the receptors for the Fc portion of IgG molecules (Fc gamma R) are widely distributed in cells of the immune system. The expression of Fc gamma R enables monocytes and neutrophils to destroy antibody-coated target cells through the antibody-dependent cell-mediated cytotoxicity (ADCC) mechanism. In addition, the interaction of immune complexes or aggregated IgG with monocytes or neutrophils led to the lysis of nonsensitized target cells in a process known as nonspecific cytotoxicity (NSC). Despite that ADCC and NSC are both triggered through Fc gamma R, the cytolytic mechanism involved in each reaction is different. In this paper we analyze the ability of human monoclonal IgG1, IgG2, IgG3 and IgG4 to induce ADCC and NSC. Our results demonstrate that each IgG subclass is able to induce both, NSC and ADCC, mediated by monocytes or neutrophils, indicating that there is no correlation between IgG subclass specificity and the ability to activate both mechanisms.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Isturiz MA,Geffner JR,Pizzolato MAdoi
10.1016/0165-2478(91)90182-asubject
Has Abstractpub_date
1991-08-01 00:00:00pages
271-5issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(91)90182-Ajournal_volume
29pub_type
杂志文章abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.06.015
更新日期：2014-11-01 00:00:00
abstract：:The first step in the clearance of apoptotic cells is chemotactic migration of macrophages towards the apoptotic cells guided by find-me signals provided by the dying cells. Upon sensing the chemotactic signals, macrophages release ATP. ATP is then degraded to ADP, AMP and adenosine to trigger purinergic receptors con...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.02.002
更新日期：2017-03-01 00:00:00
abstract：:Antigen receptor (AgR) crosslinking by antigens or AgR-specific antibodies induces a cascade of enzymatic events in lymphocytes which involves activation of several non-receptor tyrosine- and serine/threonine kinases, phosphatases, phospholipases, etc. Here we show data demonstrating that a thiol group-reactive protei...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90031-v
更新日期：1993-08-01 00:00:00
abstract：:The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 μM)-dependently increased the HO-1 mRNA and protein expression associated with increased...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.01.003
更新日期：2011-05-01 00:00:00
abstract：:We have explored the requirements for the induction of the N-formyl-methionyl-leucyl-phenylalanine (FMLP) response in Daudi cells after anti-immunoglobulin treatment. Our results indicate that (a) induction of responsiveness to FMLP was observed in Daudi only after crosslinking of surface immunoglobulin by anti-immuno...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90110-a
更新日期：1992-04-01 00:00:00
abstract：:Interleukin (IL) 4 is a type 2 cytokine which has a negative immunoregulatory role in human infection. IL-4 suppresses the production of interferon-gamma and enhances IL-10 synthesis. However, the effect of IL-4 on proliferative response of lymphocytes remains to be elucidated. We have previously reported an increase ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02440-9
更新日期：1995-11-01 00:00:00
abstract：:Several studies have implicated a role for the cell surface glycoprotein CD44 in lymphocyte differentiation, adhesion to the matrix, homing, activation and apoptosis. However, the requirement of CD44 in B cell maturation remains elusive. To address this point, we analyzed the generation and activation of B lymphocytes...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.06.004
更新日期：2004-08-15 00:00:00
abstract：:RASI-1 is a novel matrix metalloproteinase which we isolated from an expression cDNA library representing the mRNA of an inflamed synovium obtained from a patient with rheumatoid arthritis (RA). To investigate the involvement of RASI-1 in the pathology of RA, we examined synovial specimens from RA patients with antibo...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00057-6
更新日期：1997-06-01 00:00:00
abstract：:It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02497-2
更新日期：1996-03-01 00:00:00
abstract：:HLA class II molecules play pivotal roles in antigen presentation to CD4+ T cells. We investigated signaling via HLA-DR molecules expressed on CD4+ T cells. When HLA-DR or CD3 molecules on cloned CD4+ T cells were cross-linked by solid-phase mAbs, T cells proliferated, and this resulted in anergy. Whereas cross-linkin...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00341-8
更新日期：2002-04-22 00:00:00
abstract：:A novel mutant strain of rats, LEC, exhibits an arrest of T-cell maturation from CD4+CD8+ to CD4+CD8- but not the CD4-CD8+ cells in the thymus. Nevertheless, CD4+T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell rece...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00254-o
更新日期：1995-03-01 00:00:00
abstract：:Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.10.003
更新日期：2010-01-04 00:00:00
abstract：:The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota and food antigens. Dendritic cells (DC) generate primary T-cell responses, and determine whether these responses are immunogenic or tolerogenic. The regulatory role of D...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.01.007
更新日期：2013-02-01 00:00:00
abstract：:To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90101-7
更新日期：1993-06-01 00:00:00
abstract：:Adult B-acute lymphoblastic leukemia (B-ALL) does not share the favorable prognosis seen in pediatric patients with the same disease. Less than 50% of patients experience long-term survival and for those adults over age 60, long-term survival is only 10%. At time of relapse, 5-year prognosis is a dismal 7%. Novel and ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2016.02.014
更新日期：2016-04-01 00:00:00
abstract：:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90086-1
更新日期：1987-01-01 00:00:00
abstract：:N-Chlorotaurine (NCT) plays an important role in the human defense system as a main component of long-lived oxidants, and shows bactericidal, fungicidal, and virucidal activity. Besides this role, NCT seems to act regulatory on immunocompetent cells by altering cytokine production. NCT inhibited nitric oxide, TNF-alph...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.03.006
更新日期：2004-05-15 00:00:00
abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90183-x
更新日期：1994-05-01 00:00:00
abstract：:In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90095-x
更新日期：1981-04-01 00:00:00
abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02570-9
更新日期：1996-07-01 00:00:00
abstract：:We studied CD10 Ag of neutral endopeptidase (NEP) and CD13 Ag of aminopeptidase N (APN) expression on peripheral blood mononuclear cells (PBMC) as cells activation markers and for their transendothelial migration properties in three groups of MS patients (total 58); with acute exacerbation of MS (n = 18), primary prog...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00176-5
更新日期：2000-02-01 00:00:00
abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.09.004
更新日期：2003-12-15 00:00:00
abstract：:We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.03.008
更新日期：2007-05-15 00:00:00
abstract：:The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.06.005
更新日期：2012-09-01 00:00:00
abstract：:A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90021-0
更新日期：1986-11-17 00:00:00
abstract：:Circulating lymphocytes were enumerated in 25 patients with coeliac disease and in 24 healthy donors by immunofluorescent staining using monoclonal antibodies for T cell surface phenotypic markers T11 (mature), T4 (helper) and T8 (suppressor) or polyvalent antisera for surface immunoglobulins (B cells). Proportions of...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90119-7
更新日期：1986-08-01 00:00:00
abstract：:Several recent studies have shown that the antigen receptors (mIgM and mIgD) on normal B cell surfaces are part of larger multimolecular complexes, as each is noncovalently coupled to at least two other proteins whose phosphorylation is inducible upon G protein activation. However, B cell receptor complexes appear to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90050-x
更新日期：1992-05-01 00:00:00
abstract：:The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90090-b
更新日期：1992-06-01 00:00:00
abstract：:The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00126-0
更新日期：1998-01-01 00:00:00
abstract：:Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.020
更新日期：2006-03-15 00:00:00
