Abstract:
:The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding to fetal levels of this protein in plasma, the production and secretion of interleukin 1beta (IL-1beta) and nitric oxide (NO) is almost abolished, tumour necrosis factor-alpha (TNF-alpha) reduced, while that of IL-6 is not affected. On the other hand, concentrations of fetuin corresponding to adult plasma levels (i.e. 40-60 mg/100 ml) were without much effect on macrophage synthesis and secretion of these cytokines.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Dziegielewska KM,Andersen NA,Saunders NRdoi
10.1016/s0165-2478(97)00126-0subject
Has Abstractpub_date
1998-01-01 00:00:00pages
31-5issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(97)00126-0journal_volume
60pub_type
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journal_title:Immunology letters
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journal_title:Immunology letters
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更新日期:2004-09-01 00:00:00
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journal_title:Immunology letters
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doi:10.1016/j.imlet.2007.12.003
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journal_title:Immunology letters
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更新日期:2016-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:2008-02-15 00:00:00
abstract::A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...
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更新日期:1996-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1988-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:2008-03-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.01.006
更新日期:2019-11-01 00:00:00