Modification of macrophage response to lipopolysaccharide by fetuin.

Abstract:

:The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding to fetal levels of this protein in plasma, the production and secretion of interleukin 1beta (IL-1beta) and nitric oxide (NO) is almost abolished, tumour necrosis factor-alpha (TNF-alpha) reduced, while that of IL-6 is not affected. On the other hand, concentrations of fetuin corresponding to adult plasma levels (i.e. 40-60 mg/100 ml) were without much effect on macrophage synthesis and secretion of these cytokines.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Dziegielewska KM,Andersen NA,Saunders NR

doi

10.1016/s0165-2478(97)00126-0

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

31-5

issue

1

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(97)00126-0

journal_volume

60

pub_type

杂志文章
  • IL-6 antisense oligonucleotides inhibit IgE production in IL-4 and anti-CD40-stimulated human B-lymphocytes.

    abstract::Stimulation of tonsillar B-lymphocytes with CD40 antibodies and IL-4 leads to homotypic adhesion, proliferation, and differentiation into Ig-producing cells. It also leads to the production of IL-6, a pleiotropic cytokine involved in B-cell maturation and differentiation. To assess the importance of IL-6 in the differ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(97)00140-5

    authors: Björck P,Larsson S,Andäng M,Ahrlund-Richter L,Paulie S

    更新日期:1998-03-01 00:00:00

  • Maternal T cells promote placental growth and prevent spontaneous abortion.

    abstract::Transplantation immunologists have long been intrigued by the natural allograft that results from normal mammalian pregnancy. Its general success contrasts with the rejection problems associated with most artifactual organ transplantation and raises intriguing questions concerning the nature of the mechanisms involved...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0165-2478(88)90001-6

    authors: Wegmann TG

    更新日期:1988-04-01 00:00:00

  • TCRalphabeta repertoire diversity of human naturally occurring CD4+CD25+ regulatory T cells.

    abstract::We examined the alphabeta T cell receptor (TCR) repertoire of naturally occurring CD4+CD25+ regulatory T (Treg) cells isolated from healthy human blood. Three-color FACS analysis demonstrated that the usage of variable region segments of TCRbeta chains by CD4+CD25+ cells did not differ from those of CD4+CD25- cells. C...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2005.02.011

    authors: Fujishima M,Hirokawa M,Fujishima N,Sawada K

    更新日期:2005-07-15 00:00:00

  • Considering genetic profiles in functional studies of immune responsiveness to HIV-1.

    abstract::Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-2478(01)00275-9

    authors: Carrington M,Nelson G,O'Brien SJ

    更新日期:2001-11-01 00:00:00

  • Enhanced expression of B7.2 (CD86) by percutaneous sensitization with house dust mite antigen.

    abstract::House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(02)00196-7

    authors: Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

    更新日期:2003-01-02 00:00:00

  • Analysis of dendritic cell trafficking using EGFP-transgenic mice.

    abstract::Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response, DC should migrate from the periphery to the lymph node to present the antigen to T lymphocytes. Currently, tumor-antigen loaded DCs are used in clinical vaccinat...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(03)00105-6

    authors: Eggert AA,van der Voort R,Torensma R,Moulin V,Boerman OC,Oyen WJ,Punt CJ,Diepstra H,de Boer AJ,Figdor CG,Adema GJ

    更新日期:2003-10-09 00:00:00

  • LMP-1, the Epstein-Barr virus-encoded oncogene with a B cell activating mechanism similar to CD40.

    abstract::Many details in the expression pattern of Epstein-Barr virus (EBV)-encoded proteins, their role in blast and growth transformation in infected B lymphocytes are known, but 'black holes' still exist. The two main types of virus-B lymphocyte interactions are denoted as Type I and Type III. These are characterized by the...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-2478(99)00044-9

    authors: Klein E,Teramoto N,Gogolák P,Nagy N,Björkholm M

    更新日期:1999-05-03 00:00:00

  • Sex-dependent differences in the IgE response modulated by phytohemagglutinin.

    abstract::Modulation of the IgE response by PHA treatment in relation to animal sex was analysed. Male and female RF mice were immunized with ovalbumin in aluminum hydroxide gel and PHA was injected 1 or 2 days before immunization. Castrated mice were also immunized and received PHA on day -2. The results show that the IgE resp...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(87)90056-3

    authors: Astorquiza MI,Cisternas C,Leal X

    更新日期:1987-10-01 00:00:00

  • Insight into lymphoid tissue morphogenesis.

    abstract::Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves int...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2013.08.001

    authors: Coles M,Veiga-Fernandes H

    更新日期:2013-11-01 00:00:00

  • Naturally occurring immune response against bacteria commonly involved in upper respiratory tract infections: analysis of the antigen-specific salivary IgA levels.

    abstract::Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(02)00290-0

    authors: Rossi GA,Peri C,Raynal ME,Defilippi AC,Risso FM,Schenone G,Pallestrini E,Melioli G

    更新日期:2003-03-03 00:00:00

  • Rapidly decreased serum IgG to Campylobacter pylori following elimination of Campylobacter in histological chronic biopsy Campylobacter-positive gastritis.

    abstract::The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(89)90069-2

    authors: van Bohemen CG,Langenberg ML,Rauws EA,Oudbier J,Weterings E,Zanen HC

    更新日期:1989-01-15 00:00:00

  • Artin M: a rational substitution for the names artocarpin and KM+.

    abstract::The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...

    journal_title:Immunology letters

    pub_type: 信件

    doi:10.1016/j.imlet.2008.06.002

    authors: Pereira-da-Silva G,Roque-Barreira MC,Van Damme EJ

    更新日期:2008-08-15 00:00:00

  • Two genetic variants in the promoter region of the CCL5 gene are associated with the risk of acute coronary syndrome and with a lower plasma CCL5 concentration.

    abstract::Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2020.10.006

    authors: Herrera-Maya G,Vargas-Alarcon G,Ramirez-Bello J,Perez-Mendez O,Posadas-Sanchez R,Lopez-Marure R,Granados J,Nieto-Lima B,Fragoso JM

    更新日期:2020-12-01 00:00:00

  • Mitogenic effect of prolactin on chicken lymphocytes in vitro.

    abstract::Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(90)90044-q

    authors: Skwarło-Sońta K

    更新日期:1990-06-01 00:00:00

  • Follicular helper T cell-mediated mucosal barrier maintenance.

    abstract::The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2014.07.015

    authors: Winstead CJ

    更新日期:2014-12-01 00:00:00

  • Anti-oxidized low density lipoprotein antibody determination as a predictor of restenosis following percutaneous transluminal coronary angioplasty.

    abstract::Recent data suggests that autoimmune factors play an important role in the pathogenesis of atherosclerosis. In this context several autoantigens have been shown to elicit an immune response that results in accelerated atherosclerotic plaque formation. In the present study, we investigated whether elevated titers of an...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(99)00050-4

    authors: George J,Harats D,Bakshi E,Adler Y,Levy Y,Gilburd B,Shoenfeld Y

    更新日期:1999-06-01 00:00:00

  • The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration.

    abstract::The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to establish the time-dependent relation between plasma cytokines interleukin (IL)-10, transforming growth factor (TGF)-beta1, ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2004.07.009

    authors: Monneret G,Finck ME,Venet F,Debard AL,Bohé J,Bienvenu J,Lepape A

    更新日期:2004-09-01 00:00:00

  • FcgammaRI (CD64) resides constitutively in lipid rafts.

    abstract::Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2007.12.003

    authors: Beekman JM,van der Linden JA,van de Winkel JG,Leusen JH

    更新日期:2008-03-15 00:00:00

  • Light-chain profiles in sera from patients with subacute sclerosing panencephalitis.

    abstract::Sera from 2 subacute sclerosing panencephalitis (SSPE) patients were absorbed with a concentrated preparation of measles virus. Measles-specific IgG was eluted from the precipitates containing measles antigen-antibody complex. These IgGs, when subjected to immunofixation after isoelectric focusing showed a number of o...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(82)90002-5

    authors: Mehta PD,Thormar H

    更新日期:1982-02-01 00:00:00

  • Novel heterogeneity of the leucocyte common antigen (CD45): disulfide-bound heterodimers between CD45 and an 80 kDa polypeptide.

    abstract::The leukocyte common antigen, CD45, is one of the major glycoproteins on cells of hemopoietic origin showing considerable heterogeneity in both structure and expression. Biochemical heterogeneity has been attributed to differences in the primary sequence and glycosylation. In this paper we report an additional basis f...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(94)90198-8

    authors: Oravecz T,Monostori E,Adrian O,Kurucz E,Andó I

    更新日期:1994-04-01 00:00:00

  • WITHDRAWN: The anti-cancer properties in parallel with toxic effects of indole-3-carbinol derivatives.

    abstract::This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

    journal_title:Immunology letters

    pub_type: 撤回出版物

    doi:10.1016/j.imlet.2017.08.015

    authors: Karimabad MN,Falahati-Pour SK,Hassanshahi G,Koochakzadeh L

    更新日期:2017-08-26 00:00:00

  • Fetal calf serum-primed dendritic cells induce a strong anti-fetal calf serum immune response and diabetes protection in the non-obese diabetic mouse.

    abstract::In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2006.11.007

    authors: Kadri N,Potiron N,Ouary M,Jegou D,Gouin E,Bach JM,Lieubeau B

    更新日期:2007-02-15 00:00:00

  • Prognostic value of indoleamine 2,3-dioxygenase activity and expression in nasopharyngeal carcinoma.

    abstract::Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2015.11.012

    authors: Ben-Haj-Ayed A,Moussa A,Ghedira R,Gabbouj S,Miled S,Bouzid N,Tebra-Mrad S,Bouaouina N,Chouchane L,Zakhama A,Hassen E

    更新日期:2016-01-01 00:00:00

  • C3b acceptors on macrophages: inhibition of Fc gamma-receptor-mediated phagocytosis by acceptor-bound C3b.

    abstract::The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhib...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(83)90068-8

    authors: Fábry Z,Erdei A,Gergely J

    更新日期:1983-06-01 00:00:00

  • Autoimmune regulator expression in thymomas with or without autoimmune disease.

    abstract:BACKGROUND:The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs) can down-regulate autoimmunity, but also promote tumor growth. The objective of this study was to examine the levels of AIRE, AchR, and Foxp3 ex...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2014.04.008

    authors: Liu Y,Zhang H,Zhang P,Meng F,Chen Y,Wang Y,Yao Y,Qi B

    更新日期:2014-09-01 00:00:00

  • MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

    abstract::Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2007.11.015

    authors: Reiling N,Ehlers S,Hölscher C

    更新日期:2008-02-15 00:00:00

  • Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion.

    abstract::A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(96)02519-9

    authors: Krishnaraj R,Bhooma T

    更新日期:1996-04-01 00:00:00

  • Effect of an autoreactive T cell clone from (NZB x NZW)F1 mice on the production of anti-DNA antibodies in vivo and in vitro.

    abstract::An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(88)90175-7

    authors: Naiki M,Imai Y,Kamita Y,Osawa T

    更新日期:1988-08-01 00:00:00

  • Critical roles of the PI3K/Akt signaling pathway in T cell development.

    abstract::Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2007.12.008

    authors: Juntilla MM,Koretzky GA

    更新日期:2008-03-15 00:00:00

  • Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function.

    abstract::Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2019.01.006

    authors: Cerny O,Holden DW

    更新日期:2019-11-01 00:00:00