Abstract：
:N-Chlorotaurine (NCT) plays an important role in the human defense system as a main component of long-lived oxidants, and shows bactericidal, fungicidal, and virucidal activity. Besides this role, NCT seems to act regulatory on immunocompetent cells by altering cytokine production. NCT inhibited nitric oxide, TNF-alpha, and prostaglandin E(2) (PGE(2)) production in activated rodent macrophages, and suppressed superoxide anion, IL-6, and IL-8 formation in human polymorphonuclear leukocytes. In this study, the influence of NCT on the production of neopterin and the activation of the enzyme indoleamine-2,3 dioxygenase (IDO) was investigated in human peripheral blood mononuclear cells (PBMC). Both events are well established to be triggered by IFN-gamma and therefore related to Th1-type immune activation. Mitogen-induced neopterin production as well as tryptophan degradation were drastically reduced upon addition of NCT. Results fit in the concept of a reduction of pro-inflammatory cytokines by this compound. In contrast to earlier results, where NCT was suggested to act primarily down-regulatory on Th2 cells, we propose also a strong suppressive effect of NCT on Th1-type immunity.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Wirleitner B,Neurauter G,Nagl M,Fuchs Ddoi
10.1016/j.imlet.2004.03.006subject
Has Abstractpub_date
2004-05-15 00:00:00pages
143-9issue
2-3eissn
0165-2478issn
1879-0542pii
S0165247804000641journal_volume
93pub_type
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pub_type： 杂志文章
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journal_title：Immunology letters
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journal_title：Immunology letters
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更新日期：2006-08-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2013-02-01 00:00:00
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doi：10.1016/j.imlet.2016.02.004
更新日期：2016-04-01 00:00:00
