Hybridoma autoantibodies to erythrocytes from NZB mice and the induction of hemolytic anemia.

abstract：:Phosphatidylinositol 3-kinase (PI3K) is critical player in cell proliferation and survival. The effects of LY294002 and wortmannin, inhibitors of PI3K, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in lipoploysaccharide (LPS)-induced Raw 264.7 cells were investigated. Significan...

journal_title：Immunology letters

authors： Kim YH,Choi KH,Park JW,Kwon TK

更新日期：2005-06-15 00:00:00

abstract：:Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl-->up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines incr...

journal_title：Immunology letters

authors： Watanabe M,Tomiyama-Miyaji C,Kainuma E,Inoue M,Kuwano Y,Ren H,Shen J,Abo T

更新日期：2008-01-15 00:00:00

abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

journal_title：Immunology letters

authors： Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

更新日期：2009-01-29 00:00:00

abstract：BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...

journal_title：Immunology letters

authors： Kőhalmi KV,Veszeli N,Cervenak L,Varga L,Farkas H

更新日期：2017-09-01 00:00:00

abstract：:Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral i...

journal_title：Immunology letters

authors： Heidkamp GF,Neubert K,Haertel E,Nimmerjahn F,Nussenzweig MC,Dudziak D

更新日期：2010-08-16 00:00:00

abstract：:To examine whether grape seed proanthocyanidin extract (GSPE) which is known to act as an antioxidant has therapeutic effect on collagen-induced arthritis (CIA) in mice, an animal model of rheumatoid arthritis. Mice were treated with an intraperitoneal injection of GSPE (10, 50, or 100 mg/kg) or saline. Clinical, hist...

journal_title：Immunology letters

authors： Cho ML,Heo YJ,Park MK,Oh HJ,Park JS,Woo YJ,Ju JH,Park SH,Kim HY,Min JK

更新日期：2009-06-04 00:00:00

abstract：:Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...

journal_title：Immunology letters

authors： An H,Xu H,Yu Y,Zhang M,Qi R,Yan X,Liu S,Wang W,Guo Z,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:Domain deleted paraproteins are suitable tools to study the interaction between IgG domains and Fc receptor (FcR) binding sites. The effect of the C gamma 2 or C gamma 3 domain deleted paraproteins was compared on antibody dependent cellular cytotoxicity (ADCC) and on FcR mediated rosette formation. The C gamma 2 doma...

journal_title：Immunology letters

authors： Sármay G,Jefferis R,Gergely J

更新日期：1986-06-01 00:00:00

abstract：:The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V(H)DJ(H) 17.2.25 (V(H)T) encoded H chain and the lambda1 or lambda2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during...

journal_title：Immunology letters

authors： Kouyama E,Nishikawa Y,Okazawa T,Magari M,Ohmori H,Kanayama N

更新日期：2007-03-15 00:00:00

abstract：:Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...

journal_title：Immunology letters

authors： Zhang K,Sun YL,Zhou SN,Xu RN,Liu ZW,Wang FS,Shi M

更新日期：2019-09-01 00:00:00

abstract：:The immunosuppressant rapamycin is known to be a potent inhibitor of cytokine driven proliferation of T-lymphocytes and other cell types. Here we have examined the effect of rapamycin on the myeloblastic cell line M1 which responds to interleukin-6 (IL-6) with growth arrest and monocytoid differentiation. Single-agent...

journal_title：Immunology letters

authors： Kloke O,Kummer G,Seeber S

更新日期：1997-11-01 00:00:00

abstract：:Cigarette smoke contains nicotine, an immunomodulatory component that is thought to affect immune surveillance and increase the progression of diseases. Dendritic cells (DCs) constitute a family of antigen-presenting (APCs) with inherent abilities to sense and translate environmental cues and to shape host immunity. W...

journal_title：Immunology letters

authors： Nouri-Shirazi M,Tinajero R,Guinet E

更新日期：2007-04-15 00:00:00

abstract：:The antischistosomal property of a short course of cyclosporin A (CsA), administered at the time of infection was demonstrated in the rat. In comparison with vehicle-treated controls, no schistosomes were recovered from CsA-treated animals, 18-19 days post infection. Flow cytometric analysis of blood and spleen lympho...

journal_title：Immunology letters

authors： Thomson AW,Chappell LH

更新日期：1988-02-01 00:00:00

abstract：:In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey...

journal_title：Immunology letters

authors： Yoshida T,Suzuki S,Iwasaki Y,Kaneko A,Saito A,Enomoto Y,Higashino A,Watanabe A,Suzuki J,Inoue K,Kuroda T,Takada M,Ito R,Ito M,Akari H

更新日期：2013-07-01 00:00:00

abstract：:It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispe...

journal_title：Immunology letters

authors： Brzezińska-Błaszczyk E,Pietrzak A

更新日期：1997-12-01 00:00:00

abstract：:Monoclonal antibodies of the Orthoclone series were used to identify total T lymphocytes (OKT3) and their helper-inducer (OKT4) and cytotoxic-suppressor (OKT8) subsets in 25 patients with chronic Chagas' disease and 25 healthy controls. No significant difference in the number of total T cells (OKT3+) circulating in th...

journal_title：Immunology letters

authors： Gattass CR,Albanesi Fo FM,Barcinski MA

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Considering the role of interleukin (IL)-9 and IL-9-producing Th9 cells in pathogenesis of autoimmune diseases, this study aimed to evaluate serum IL-9 levels in patients with Behçet's disease (BD) compared to healthy subjects and to assess whether there is an association between serum IL-9 levels and dise...

journal_title：Immunology letters

authors： Nouri-Vaskeh M,Malek Mahdavi A,Khabbazi A,Jadideslam G

更新日期：2019-07-01 00:00:00

abstract：:This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...

journal_title：Immunology letters

authors： Zhang J,Xu M,Zheng Q,Zhang Y,Ma W,Zhang Z

更新日期：2014-11-01 00:00:00

abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...

journal_title：Immunology letters

authors： Watanabe S,Ohnuki K,Hara Y,Ishida Y,Ikarashi Y,Ogawa S,Kishimoto H,Tanabe K,Abe R

更新日期：2010-01-18 00:00:00

abstract：:When IL-4 mRNA was distinguished from mRNA encoding its antagonist, the splice variant IL-4delta2, it was found to correlate directly with expression of TLR2 in fresh peripheral blood mononuclear cells (PBMCs) from normal donors (p=0.0013). Similarly IL-4 mRNA was high when TLR2 mRNA was abundant compared to levels of...

journal_title：Immunology letters

authors： Chang JS,Dheda K,Huggett JF,Kim LU,Zumla A,Rook GA

更新日期：2006-08-15 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

journal_title：Immunology letters

authors： Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

更新日期：2005-11-15 00:00:00

abstract：:Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...

journal_title：Immunology letters

authors： Dedeoglu F,Kaymaz H,Klein G,Marchalonis JJ

更新日期：1993-11-01 00:00:00

abstract：:Different splice variants of the CD44 cell-surface molecule have been linked to metastasis formation in several animal and human cancers. We have used metastatic CSML-100 and non-metastatic CSML-0 mouse adenocarcinoma cell lines to determine whether variant CD44 molecules could be implicated in the different behaviour...

journal_title：Immunology letters

authors： Tkach T,Li E,Bestagno M,Burrone OR

更新日期：1996-09-01 00:00:00

abstract：:The HIV-1 envelope protein contains several regions with amino acid homology to HLA class I and class II molecules. We evaluated possible changes in antibody responses to those regions during vaccination with rgp 160 produced in a baculovirus system. Forty asymptomatic HIV-infected patients with CD4 cell counts above ...

journal_title：Immunology letters

authors： Lundholm P,Wahren M,Sandström E,Volvovitz F,Wahren B

更新日期：1994-07-01 00:00:00

abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...

journal_title：Immunology letters

authors： Mbarik M,Kaabachi W,Henidi B,Sassi FH,Hamzaoui K

更新日期：2015-07-01 00:00:00

abstract：:In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...

journal_title：Immunology letters

authors： Bradley JA

更新日期：1991-07-01 00:00:00

abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...

journal_title：Immunology letters

authors： Inuzuka S,Koga S,Nishikido M,Miyata Y,Kanda S,Shimokawa I,Tanaka M,Saito Y,Kanetake H

更新日期：2002-09-02 00:00:00

abstract：:African swine fever (ASF) virus has been reported to infect cells of the monocyte family, probably macrophage-like cells, but there is variation in the apparent susceptibility of these cells. We have demonstrated that the phenotype and activity of porcine monocytic cells varies between different isolations and also up...

journal_title：Immunology letters

authors： McCullough KC,Schaffner R,Fraefel W,Kihm U

更新日期：1993-07-01 00:00:00

abstract：:Good Syndrome is a rare clinical entity first described as the conjunction of thymoma and hypogammaglobulinemia, and more recently depicted as a complex disease integrating a medical history of thymoma with humoral immunodeficiency (more accurately stated: hypogammaglobulinemia) with or without cellular immunodeficien...

journal_title：Immunology letters

authors： Guevara-Hoyer K,Fuentes-Antrás J,Calatayud Gastardi J,Sánchez-Ramón S

更新日期：2021-01-05 00:00:00

abstract：:Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a mu...

journal_title：Immunology letters

authors： Yoshie O,Wada J,Ishida N

更新日期：1985-01-01 00:00:00