Abstract：
:Treatment of purified human C5 with hydrogen peroxide leads to a reduction of functional activity in the classical immune haemolysis assay. The effect of H2O2 is enhanced by traces of iron-EDTA, and becomes even stronger when ascorbic acid is present in addition. The enhancement by iron and protective effects of various radical scavengers indicate that the conversion of C5 is brought about by hydroxyl radicals mainly, generated from H2O2 during its decomposition. By the conversion C5 acquires a new functional property: it becomes capable of binding C6, and the resulting complex C56 lyses non-sensitized red cells in cooperation with the late components C7, C8, and C9 (reactive lysis). In this respect, H2O2-treated C5 resembles the activation fragment of C5, C5b. However, unlike C5b, C5(H2O2) is not fragmented but comprises the whole molecule, according to polyacrylamide gel electrophoresis. In accordance with the lack of cleavage, no chemotactic activity indicating formation of C5a, became apparent after H2O2 treatment of C5. In whole human serum, however, the H2O2 system induces additional processes leading to the generation of C5a activity and indicating C5 cleavage. The pathways to this reaction are as yet not clear. The effect of oxygen radicals on C5 may be the basis of the enhancing effect of stimulated leukocytes on C5 activation in body fluids. Activated leukocytes are known to produce H2O2 and oxygen radicals.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
von Zabern WV,Hesse D,Nolte R,Haller Ydoi
10.1016/0165-2478(87)90103-9subject
Has Abstractpub_date
1987-02-01 00:00:00pages
209-15issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(87)90103-9journal_volume
14pub_type
杂志文章abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90037-3
更新日期：1984-01-01 00:00:00
abstract：:DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00235-8
更新日期：2001-09-03 00:00:00
abstract：:We have recently generated CD4 clones from BALB/c mice immunized with a plasmid DNA containing the gene encoding for the catalytic domain of trans-sialidase, an important enzyme expressed on the surface of Trypanosoma cruzi trypomastigotes. These clones allowed us to study in vitro the interaction between T cells and ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00205-4
更新日期：2000-07-03 00:00:00
abstract：:A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02550-3
更新日期：1996-06-01 00:00:00
abstract：:A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90157-x
更新日期：1987-12-01 00:00:00
abstract：:Adult B-acute lymphoblastic leukemia (B-ALL) does not share the favorable prognosis seen in pediatric patients with the same disease. Less than 50% of patients experience long-term survival and for those adults over age 60, long-term survival is only 10%. At time of relapse, 5-year prognosis is a dismal 7%. Novel and ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2016.02.014
更新日期：2016-04-01 00:00:00
abstract：:We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00153-3
更新日期：1998-02-01 00:00:00
abstract：:Modulation of the IgE response by PHA treatment in relation to animal sex was analysed. Male and female RF mice were immunized with ovalbumin in aluminum hydroxide gel and PHA was injected 1 or 2 days before immunization. Castrated mice were also immunized and received PHA on day -2. The results show that the IgE resp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90056-3
更新日期：1987-10-01 00:00:00
abstract：:Experimental systemic lupus erythematosus (SLE), similar to that observed after immunization with the human anti-DNA mAb 16/6 Id+, could be induced in mice by injection of 16/6 Id specific T-cell lines. The above T-cell lines were exclusively CD4+ CD8- and the majority of cells expressed the Vbeta8 T-cell receptor (TC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00156-9
更新日期：1998-05-01 00:00:00
abstract：:Differentiation between a non-infective and an infective Leishmania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigote...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90114-2
更新日期：1985-01-01 00:00:00
abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.005
更新日期：2009-09-22 00:00:00
abstract：:Graft failure (GF) following bone marrow transplantation (BMT) in man is usually attributed to allograft rejection; however, other mechanisms of GF exist. Exposure of the developing allograft to viruses, myelotoxic drugs, and damage to the host-derived marrow stroma during graft-versus-host disease (GVHD) may all caus...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90204-n
更新日期：1991-07-01 00:00:00
abstract：:The immunosuppressant rapamycin is known to be a potent inhibitor of cytokine driven proliferation of T-lymphocytes and other cell types. Here we have examined the effect of rapamycin on the myeloblastic cell line M1 which responds to interleukin-6 (IL-6) with growth arrest and monocytoid differentiation. Single-agent...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00110-7
更新日期：1997-11-01 00:00:00
abstract：:Adoptive transfer of multivirus-specific T cell lines (MVST) is an advanced tool for immunotherapy of virus infections after hematopoietic stem cell transplantation (HSCT). Their preparation includes activation of donor virus-specific T cells by the mixture of oligopeptides derived from immunodominant antigens of seve...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.09.009
更新日期：2020-12-01 00:00:00
abstract：:Dendritic cells (DCs) differentiated in the presence of IL-10 preferentially induce regulatory T-cells and tolerance. Whether the tolerogenic properties displayed by these DCs (Tol-DCs) can be overcome has not been fully explored. Here we show for the first time that Tol-DCs express higher levels of TLR5 mRNA, but not...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.06.007
更新日期：2009-08-15 00:00:00
abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90151-f
更新日期：1990-12-01 00:00:00
abstract：:Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.06.009
更新日期：2020-09-01 00:00:00
abstract：:H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90111-0
更新日期：1982-11-01 00:00:00
abstract：:Recent studies indicate that the pulmonary immune response in humans and experimental animals is different in newborn, adult and elderly age groups. The aim of this study was to investigate the influence of age on the leukocyte composition in different lung compartments and peripheral blood of weaned and adult rats. A...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.008
更新日期：2007-02-15 00:00:00
abstract：:The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(98)00153-9
更新日期：1999-03-01 00:00:00
abstract：:CD24 is a heavy glycosylated protein that is overexpressed in numerous cancer and cancer stem cells. It is involved in the development, invasion, and metastasis of the cancer cells. CD24 can be considered in targeted cancer therapy as a new target. Here, phage display technology was used for the identification of nove...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.08.028
更新日期：2017-10-01 00:00:00
abstract：:Microparticles are recently recognized players of intercellular communication. They are involved in signal transduction, cell activation and apoptosis. Their importance is also suggested in autoimmune diseases such as rheumatoid arthritis and systemic sclerosis. We investigated the role of microparticles in polymyosit...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.12.018
更新日期：2010-02-16 00:00:00
abstract：:T cells recognize with a single receptor both a product of antigens processed by antigen presenting cells (APC1) and a self-marker molecule, encoded by the major histocompatibility complex (MHC, a property termed MHC-restricted recognition of antigen). During their differentiation in the thymus, T cells "learn" what t...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(90)90040-w
更新日期：1990-06-01 00:00:00
abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.05.002
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Notch pathway is highly conserved across species and is involved in the regulation of cell differentiation and activity both in embryonic development and adult life. Notch signaling has an important role in the development of hematopoietic stem cells and their differentiation to committed lineages, as well a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.04.010
更新日期：2020-07-01 00:00:00
abstract：:Nervous and immune systems share specific recognition molecules for signals that originate in both systems. The information substances are polypeptides and their receptors. They comprise the multi-directional information exchange network whereby brain and nervous system function including mood and emotion can be integ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(87)90171-4
更新日期：1987-12-01 00:00:00
abstract：:The effect of priming with various antigens on subsequent vaccination with the pneumococcal conjugate vaccine (CPV) was determined using BALB/c mice. Priming with pneumococcal polysaccharide or cross-reactive polysaccharide did not inhibit the IgG response to CPV immunization. Additionally, live intranasal colonizatio...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.04.013
更新日期：2006-08-15 00:00:00
abstract：:Several studies have implicated a role for the cell surface glycoprotein CD44 in lymphocyte differentiation, adhesion to the matrix, homing, activation and apoptosis. However, the requirement of CD44 in B cell maturation remains elusive. To address this point, we analyzed the generation and activation of B lymphocytes...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.06.004
更新日期：2004-08-15 00:00:00
abstract：:Opioid receptors are expressed not only on neuroendocrine cells but also on immunocompetent cells such as lymphocytes, monocytes and macrophages. micro-Opioid receptor agonists were found to exert immunosuppressive effects, whereas delta-opioid receptor agonists have been shown to act as immunostimulants. delta-Opioid...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.006
更新日期：2008-06-15 00:00:00
abstract：:Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90087-q
更新日期：1991-09-01 00:00:00
