Abstract:
:H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-2 phenotype of H mice has a "low" effect, and the gene(s) linked to the H-2 phenotype of L mice a "high" effect on the magnitude of antibody response to HGG. In H and L mice, the non-specific polygenic control of antibody responsiveness is able to compensate/counteract the inverse effect of HGG-specific H-2-linked gene(s) since the usual interline difference is observed.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Heumann AM,Mouton D,Biozzi Gdoi
10.1016/0165-2478(82)90111-0subject
Has Abstractpub_date
1982-11-01 00:00:00pages
273-6issue
5eissn
0165-2478issn
1879-0542pii
0165-2478(82)90111-0journal_volume
5pub_type
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