Abstract：
:There is increasing evidence for the role of basophils in allergic bronchial asthma. We studied the potential role of basophils in the pathogenesis of post-exercise-induced bronchoconstriction by measuring the histamine release from basophils both spontaneously and following ConA, FMLP, anti-IgE and TPA treatment. Two groups of patients with allergic asthma were studied: group I consisted of 8 patients with an exercise-induced fall in FEV1 of 20% or more, and group II had 7 patients with bronchial asthma who had less than a 5% fall in FEV1 following exercise. The mean spontaneous histamine release (SHR%) from basophils for group I was significantly larger than that of group II both before as well as at 5-10 and 60 min following exercise. The SHR% at baseline was 25 +/- 10 in group I (mean +/- SD) and 15 +/- 5 in group II (mean +/- SD). At 5-10 min following exercise it was 24 +/- 6 in group I and 11 +/- 2 in group II, while at 60 min following exercise it was 24 +/- 6 in group I and 17 +/- 2 in group II. There was no significant difference between the two groups in the effect of ConA, FMLP, anti-IgE or TPA treatment on basophil histamine release. The enhanced bronchoconstriction by exercise did not affect histamine release either spontaneously or following those 4 stimuli. It was concluded that, although patients with exercise-induced asthma have a greater degree of spontaneous histamine release, this is not affected by induced bronchoconstriction, a finding which does not support a role for basophils in exercise-induced asthma.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kivity S,Schwarz I,Agami O,Topilsky M,Fireman Edoi
10.1016/0165-2478(94)90026-4subject
Has Abstractpub_date
1994-09-01 00:00:00pages
1-5issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(94)90026-4journal_volume
42pub_type
杂志文章abstract：:Recently, we determined the molecular locations on BoNT/A of the antigenic regions recognized by blocking Abs of cervical dystonia patients immunoresistant to BoNT/A treatment. In the present work we tested the possibility of reducing the levels of the Ab response against immunodominant antigenic sites on the heavy ch...
journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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pub_type： 杂志文章
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90126-9
更新日期：1992-02-15 00:00:00
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pub_type： 杂志文章
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更新日期：1987-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
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journal_title：Immunology letters
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更新日期：1988-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90048-3
更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2010-03-10 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.12.002
更新日期：2018-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.07.013
更新日期：2009-09-22 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2000-07-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90027-8
更新日期：1989-06-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.09.010
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
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pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.05.006
更新日期：2009-06-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.09.016
更新日期：2011-01-30 00:00:00
abstract：:In this study the effect of PHA activation on the phosphatase activity of CD45 has been investigated in human leukemic T-cell lines. It has been found that in vivo activation of the cells with PHA resulted in 2-4-fold increase in enzyme activity. Addition of PHA to the postnuclear supernatant of cell lysates also resu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90086-8
更新日期：1994-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.12.007
更新日期：2005-06-15 00:00:00
abstract：:In addition to expressing inhibitory cytokines and suppressive molecules, Treg cells could downplay inflammation by releasing cytotoxic molecules and eliminating proinflammatory immune cells. Colorectal cancer (CRC) is a common malignancy that has led to many cancer-related deaths. In this study, we investigated the c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.10.007
更新日期：2020-01-01 00:00:00
abstract：:Stromal cells have been considered for a long time essentially as a structural component organizing tissue architecture, including those of secondary lymphoid organs. More recently, highly specialized stromal cell subsets were shown to differentially organize immune cell recruitment, survival, and differentiation with...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2019.02.005
更新日期：2019-11-01 00:00:00
