Abstract:
:We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of certain TCRBV gene subfamilies (TCRBV8S2 and TCRBV8S3). In contrast, no signal or a very weak message from a limited number of T cells was recorded from one heart of the control group. No alteration of TCRBV distribution was recorded in spleens of chronically infected CBA/HJ. Our findings indicate that there is a preferential TCRBV gene usage in the T cell response in the hearts of chronically infected mice. Furthermore, the pattern of CDR3 lengths in inflammatory T cells was altered.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Sunnemark D,Andersson R,Harris RA,Jeddi-Tehrani M,Orn Adoi
10.1016/s0165-2478(97)00153-3subject
Has Abstractpub_date
1998-02-01 00:00:00pages
171-7issue
2-3eissn
0165-2478issn
1879-0542pii
S0165-2478(97)00153-3journal_volume
60pub_type
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