Role of inositol starvation on ecto-5'-nucleotidase activity during mitogen-induced lymphocyte activation.

abstract：:At least three B cell subsets, B-1a (Ly-1B), B-1b and B-2, are present in the mouse periphery. B-1a and B1-b cells represent a small population in the adult spleen and are abundant in the peritonial and pleural cavities. It has been demonstrated in our laboratory that B-1b cells spontaneously proliferated in stationar...

journal_title：Immunology letters

authors： Ferreira KS,Almeida SR,Ribeiro CH,Mariano M,Lopes JD

更新日期：2003-03-03 00:00:00

abstract：:Establishment and maintenance of pregnancy represents a challenge for the maternal immune system since it has to defend against pathogens and tolerate paternal alloantigens expressed in fetal tissues. Regulatory T (Treg) cells, a subset of suppressor CD4(+) T cells, play a dominant role in the maintenance of immunolog...

journal_title：Immunology letters

authors： La Rocca C,Carbone F,Longobardi S,Matarese G

更新日期：2014-11-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...

journal_title：Immunology letters

authors： Jhun J,Lee SH,Byun JK,Jeong JH,Kim EK,Lee J,Jung YO,Shin D,Park SH,Cho ML

更新日期：2015-08-01 00:00:00

abstract：:In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and other proinflammatory mediators of joint d...

journal_title：Immunology letters

authors： Friday SC,Fox DA

更新日期：2016-06-01 00:00:00

abstract：:When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...

journal_title：Immunology letters

authors： Maurer PH,Liu DC,Grun JL

更新日期：1987-12-01 00:00:00

abstract：:Mice lacking suppressor of cytokine signaling 1 (SOCS1) accumulate CD8(+) T lymphocytes in the thymus and in the periphery. Whereas IL-7 and IL-15 promote the generation of CD8 single positive (SP) thymocytes, IL-15 drives the expansion of CD8 T cells in the periphery. Here, we investigated whether increased productio...

journal_title：Immunology letters

authors： Ilangumaran S,Gagnon J,Leblanc C,Poussier P,Ramanathan S

更新日期：2010-08-16 00:00:00

abstract：:Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...

journal_title：Immunology letters

authors： Zhao JW,Sun ZQ,Zhang XY,Zhang Y,Liu J,Ye J,Chen CC,Samten B,Wang HH,Guo XK,Zhang SL

更新日期：2014-09-01 00:00:00

abstract：:B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...

journal_title：Immunology letters

authors： Matesanz-Isabel J,Sintes J,Llinàs L,de Salort J,Lázaro A,Engel P

更新日期：2011-01-30 00:00:00

abstract：:We have previously reported that the capacity of highly malignant B16BL6 murine melanoma cells to induce cell death in naive syngeneic lymphocytes stems from the absence of major histocompatibility complex (MHC) class I glycoproteins in these melanoma cells. Our present study provides evidence that the above-mentioned...

journal_title：Immunology letters

authors： Kellman-Pressman S,Fishman D,Tsory S,Segal S

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Integrin αvβ6 can convert the transforming growth factor (TGF)-β precursor to the mature form. Resiquimod (R848) can generate TGF-β-producing regulatory T cells (Treg). Thus, to concurrent administration of specific antigen and R848 may generate antigen-specific Tregs, that is expected to restore immune tole...

journal_title：Immunology letters

authors： Ma F,Zhang YY,Yang G,Mo LH,Liu DB,Yang LT,Liu ZG,Ning Y,Yang PC

更新日期：2021-02-01 00:00:00

abstract：:Several recent findings indicate that mouse bone marrow-derived mast cells (BMMC) express RNA encoding interleukin-4 (IL-4) and secrete detectable amounts of IL-4 in response to cross-linking of Fc epsilon RI receptors, Fc gamma R receptors, or to ionomycin. We investigated the desensitization of BMMC from the view po...

journal_title：Immunology letters

authors： Nakamura M,MacGlashan D Jr

更新日期：1994-07-01 00:00:00

abstract：:The present study was designed to investigate whether human equivalents of murine T helper cell subsets can be demonstrated by propagation of peripheral blood lymphocytes (PBL) with either recombinant human (rh) interleukin (IL) 2 or rhIL4 in the presence of neutralising antibodies. Cells of both cultures, termed T-IL...

journal_title：Immunology letters

authors： Kalthoff FS,Rossiter H,Liehl E

更新日期：1991-02-01 00:00:00

abstract：:To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin...

journal_title：Immunology letters

authors： Schattner A,Hanuka N,Sarov B,Bentwich Z

更新日期：1994-04-01 00:00:00

abstract：:HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine constructs to wild...

journal_title：Immunology letters

authors： Majumder B,Gray B,McBurney S,Schaefer TM,Dentchev T,Mahalingam S,Reinhart TA,Ayyavoo V

更新日期：2003-10-31 00:00:00

abstract：:A monoclonal human rheumatoid factor (RF-AN) reactive with human Fc gamma is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having C gamma 2 or C gamma 3 domain deletions or IgG3m (5) or Ig3m (21) proteins having argi...

journal_title：Immunology letters

authors： Jefferis R,Nik Jaafar MI,Steinitz M

更新日期：1984-01-01 00:00:00

abstract：:Recombinant gp120 of the HIV-1(IIIB) isolate (BH10 clone) has been mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted. A variety of studies have shown that the CD4 binding domain (CD4bd) is very well exposed in PR12 in contrast to rgp120(LAI). Us...

journal_title：Immunology letters

authors： Jeffs SA,Gorny MK,Williams C,Revesz K,Volsky B,Burda S,Wang XH,Bandres J,Zolla-Pazner S,Holmes H

更新日期：2001-12-03 00:00:00

abstract：:Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...

journal_title：Immunology letters

authors： Salmond RJ,Williams R,Hirst TR,Williams NA

更新日期：2003-07-03 00:00:00

abstract：:Tuberculosis (TB) is a highly infectious disease and its early and precise diagnosis is essential to reduce morbidity and mortality of patients. Since the routine diagnostic tests (like Monteux, AFB smear microscopy, chest X-Ray) do not give infallible results, additional tests are always recommended. Therefore to add...

journal_title：Immunology letters

authors： Tripathi DK,Srivastava K,Nagpal KL,Shukla PK,Srivastava KK

更新日期：2019-05-01 00:00:00

abstract：:Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...

journal_title：Immunology letters

authors： Van Houdt K,Nicasi I,Van Mechelen E,Veulemans B,De Ley M

更新日期：1992-03-01 00:00:00

abstract：:The production of interleukin 1 (IL-1) by lipopolysaccharide (LPS)-stimulated myelomonocytic cell lines ML-1, THP-1 and PL-21 was significantly enhanced by the addition of insulin, insulin-like growth factor (IGF)-I or IGF-II into the cell cultures. The IL-1 activity in the supernatants from cell cultures stimulated w...

journal_title：Immunology letters

authors： Holán V,Minowada J

更新日期：1992-12-01 00:00:00

abstract：:Recent data suggests that autoimmune factors play an important role in the pathogenesis of atherosclerosis. In this context several autoantigens have been shown to elicit an immune response that results in accelerated atherosclerotic plaque formation. In the present study, we investigated whether elevated titers of an...

journal_title：Immunology letters

authors： George J,Harats D,Bakshi E,Adler Y,Levy Y,Gilburd B,Shoenfeld Y

更新日期：1999-06-01 00:00:00

abstract：:The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and t...

journal_title：Immunology letters

authors： Saranath D,Masucci MG,Klein E

更新日期：1986-03-01 00:00:00

abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...

journal_title：Immunology letters

authors： Sármay G,Koncz G,Gergely J

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...

journal_title：Immunology letters

authors： Sikora J,Smycz-Kubańska M,Mielczarek-Palacz A,Bednarek I,Kondera-Anasz Z

更新日期：2018-09-01 00:00:00

abstract：:Interleukin 18 (IL-18) gene polymorphisms have been reported to be associated with the outcomes of hepatitis C virus (HCV) infection in Americans, Indians and Europeans. We aimed to investigate whether the association can be replicated in Chinese Han population. Three IL-18 variants, -656G>T, -137G>C and +105A>C, were...

journal_title：Immunology letters

authors： Yue M,Wang JJ,Tang SD,Feng L,Zhang Y,Liu Y,Wang J,Deng XZ,Xu K,Zhang J

更新日期：2013-07-01 00:00:00

abstract：:Humanized mouse models present an important tool for preclinical evaluation of new vaccines and therapeutics. Here we show the human variable repertoire of antibody sequences cloned from a previously described human immune system (HIS) mouse model that possesses functional human CD4+ T cells and B cells, namely HIS-CD...

journal_title：Immunology letters

authors： Nogueira RT,Sahi V,Huang J,Tsuji M

更新日期：2017-08-01 00:00:00

abstract：:Antibodies reactive with native double stranded DNA are characteristic of the chronic inflammatory disease systemic lupus erythematosus. Native DNA is however, a poor immunogen and the mechanism of anti-DNA antibody production is incompletely understood. Modification of DNA can increase its immunogenicity and in infla...

journal_title：Immunology letters

authors： Blount S,Griffiths HR,Staines NA,Lunec J

更新日期：1992-10-01 00:00:00

abstract：:Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...

journal_title：Immunology letters

authors： Gao P,Mu M,Chen Y,He J,Tao X,Song C

更新日期：2020-09-01 00:00:00

abstract：:In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...

journal_title：Immunology letters

authors： Caprara GV,Nisini R,Castellani V,Vittorio P,Alessandri G,Vincenzo Z,Claudia F,Valentina G,Andrea PD,Biondo MI,Milanetti F,Salerno G,Vincenzo V,Mario P,Aniballi E,Simonetta S,Angela S,D'Amelio R

更新日期：2017-08-01 00:00:00

abstract：:A variety of cell types may be involved in the regulation of IgA secretion at the intestinal mucosa. Intestinal epithelial cells (IEC) are known to have the capacity to secrete several cytokines which may exert an important regulatory effect on local immunoglobulin secretion by mucosal B cells. In this study, we have ...

journal_title：Immunology letters

authors： Goodrich ME,McGee DW

更新日期：1999-03-15 00:00:00