Abstract：
:In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acute stress test, in 41 healthy students, previously selected by a questionnaire for their level of POS (high [POS-H] and low [POS-L]). The CD3+ and CD4+ cell frequency was higher in the POS-H students before and after acute stress. CD4+ subpopulation analysis revealed baseline higher terminally differentiated frequency in the POS-H, whereas higher effector memory frequency was present in the POS-L students. Moreover, the frequency of post-stress B cells was higher in the POS-H students. The mild-stress test was associated to an increase of the IL-10 mean values, while mean values of the other cytokines tested did not change significantly. It is tempting to speculate that IL-10 may work as biomarker of response to acute mild stress and that POS-H may be associated to a better capacity of the immune system to contrast the disturbing effects of mild acute stress. Yet further studies on lymphocyte subset absolute number and function of larger and different populations are needed to definitively prove these preliminary observations.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Caprara GV,Nisini R,Castellani V,Vittorio P,Alessandri G,Vincenzo Z,Claudia F,Valentina G,Andrea PD,Biondo MI,Milanetti F,Salerno G,Vincenzo V,Mario P,Aniballi E,Simonetta S,Angela S,D'Amelio Rdoi
10.1016/j.imlet.2017.05.012subject
Has Abstractpub_date
2017-08-01 00:00:00pages
13-20eissn
0165-2478issn
1879-0542pii
S0165-2478(17)30037-8journal_volume
188pub_type
杂志文章abstract：:Two types of inhibition of basic peptide-induced rat mast cell secretion are reported. Pretreatment of rat peritoneal mast cells with Vibrio comma neuraminidase, an enzyme which cleaves sialic acid from oligosaccharides, led to inhibition of 5-hydroxytryptamine release induced by the basic peptides polylysine, cortico...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90134-1
更新日期：1982-10-01 00:00:00
abstract：:The production of neutralizing antibodies against the central portion of HIV-1 gp120 requires cooperation between T cell and B cell epitopes of this region. We found a motif common to the carboxyterminus of the second conserved region of HIV-1 gp120 and sequences of some human proteins, most of which participate in im...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90145-g
更新日期：1990-11-01 00:00:00
abstract：:Multiple antigen peptides (MAP), consisting of a number of peptide copies synthesized on a branching lysyl core, offer a novel approach for rendering small peptides immunoreactive in solid-phase immunoassays. An octameric MAP, carrying 6 repeats of the sequence -N-A-A-G-, tandem repeated in the immunodominant region o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90092-o
更新日期：1991-09-01 00:00:00
abstract：:Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90018-6
更新日期：1991-10-01 00:00:00
abstract：:Establishment and maintenance of pregnancy represents a challenge for the maternal immune system since it has to defend against pathogens and tolerate paternal alloantigens expressed in fetal tissues. Regulatory T (Treg) cells, a subset of suppressor CD4(+) T cells, play a dominant role in the maintenance of immunolog...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.06.013
更新日期：2014-11-01 00:00:00
abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.017
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the curre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.005
更新日期：2019-08-01 00:00:00
abstract：:ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(99)00024-3
更新日期：1999-05-03 00:00:00
abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.09.004
更新日期：2003-12-15 00:00:00
abstract：:In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90095-x
更新日期：1981-04-01 00:00:00
abstract：:Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(90)90093-6
更新日期：1990-08-01 00:00:00
abstract：:Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.08.011
更新日期：2017-10-01 00:00:00
abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90151-f
更新日期：1990-12-01 00:00:00
abstract：:Whilst many physiological functions of nitric oxide (NO) have been revealed so far, recent evidence proposes an essential role for NO in T lymphocyte activation and signal transduction. NO acts as a second messenger, activating soluble guanyl cyclase and participating in signal transduction pathways involving cyclic G...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.04.013
更新日期：2007-07-31 00:00:00
abstract：:There is great interest in the antibodies-to-DNA transformation, since this change is characteristic of autoimmune diseases and contributes to its pathology. After immunization and fusions, 14 hybridomas bearing DNA-hydrolysis activity against pUC19 plasmid DNA were obtained. Genes coding for V(H) and V(L) regions of ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.01.004
更新日期：2010-03-10 00:00:00
abstract：:Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2015.11.007
更新日期：2016-01-01 00:00:00
abstract：:The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90166-x
更新日期：1994-03-01 00:00:00
abstract：:In murine models, challenge with different viral and parasitic infection is closely associated with the production of type I interferons (IFN-alpha/beta) and NK cell production of interferon-gamma (IFN-gamma). Therefore, we wished to determine if IFN-alpha/beta had a role in the regulation of NK cell production of IFN...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00091-6
更新日期：1997-10-01 00:00:00
abstract：:Inflammation elicits an acute phase response, which includes changes in plasma concentrations of a number of cytokines, reflecting changes in their gene transcription in the liver. In this study, the induction of complement factor 3 (C3) was investigated in HepG2 cells, a human hepatoma cell line often used as a model...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00180-8
更新日期：2001-03-01 00:00:00
abstract：:The aim of this work was to raise allotype specific monoclonal antibodies to human CD45, with the long-term objective of producing a reagent which could be used to prolong graft survival in renal transplantation through removal of passenger leukocytes from the graft. At present there are no anti-CD45 monoclonal antibo...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00056-5
更新日期：1999-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90003-1
更新日期：1981-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90036-6
更新日期：1983-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.008
更新日期：2007-02-15 00:00:00
abstract：:The antigen receptors on the surface of B- and T-lymphocytes are complexes of several integral membrane proteins, essential for their proper expression and function. Recent studies demonstrated that transmembrane (TM) domains of the components of these receptors play a critical role in their association and function. ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(98)00100-x
更新日期：1998-12-01 00:00:00
abstract：:Luminol-dependent chemiluminescence (CL) triggered by mineral dust in rabbit alveolar macrophages depended on superoxide production as revealed by inhibition by superoxide dismutase and ferricytochrome c. The contribution of superoxide changed in the course of CL peak between 80-20%. The effects of ferricytochrome c w...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90137-4
更新日期：1987-08-01 00:00:00
abstract：:Lethally irradiated (1000 rad) CBA/J mice were transplanted with anti-Thy 1 treated BALB/c bone marrow. Under these conditions, we uniformly observed the development of pathology suggestive of acute graft-vs.-host disease (GVHD), i.e. weight loss, diarrhoea, hypogammaglobulinemia and thymic hypoplasia. If, 2 wk before...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90109-9
更新日期：1985-01-01 00:00:00
abstract：:The monocytic cell line I937 was derived from U937 by sorting for cells with high expression of MHC class II molecules. Further analysis of these class II molecules revealed the presence of the HLA-DR3 subtype suggesting that the cell line was a potential candidate for testing antigen presentation to T cells restricte...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02478-6
更新日期：1996-01-01 00:00:00
abstract：:Using the method of estimation of alpha-helical and beta-folded types of secondary structure from amino acid composition, it has been established that interferons contain about 60-70% of alpha-helices and not more than 10-20% of beta-structure. The same result was obtained using empirical and stereochemical rules for ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90070-0
更新日期：1982-01-01 00:00:00
abstract：:The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.03.007
更新日期：2017-05-01 00:00:00
abstract：:Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.014
更新日期：2014-12-01 00:00:00
