The 'monocytic' cell line I937 displays typical B cell characteristics.

abstract：:The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...

journal_title：Immunology letters

authors： Gern L,Rais O,Capiau C,Hauser P,Lobet Y,Simoen E,Voet P,Pêtre J

更新日期：1994-03-01 00:00:00

abstract：:A fragment of non-glycosylated E2 antigen of classical swine fever virus (CSFV), lacking the trans-membrane anchor (TM-) of the native glycoprotein, was produced in recombinant Escherichia coli strain BL21(DE3) in the form of inclusion bodies. These inclusion bodies isolated from the bacteria cells were administrated ...

journal_title：Immunology letters

authors： Kesik M,Saczyńska V,Szewczyk B,Płucienniczak A

更新日期：2004-02-15 00:00:00

abstract：:Foxp3+ Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self. Therefore, it is expected that lower numbers and/or less than optimal function could impact on the functioning of the immune system, and thereby contributing to the development of autoimmune diseases. In the present report, by co...

journal_title：Immunology letters

authors： Godoy GJ,Paira DA,Olivera C,Breser ML,Sanchez LR,Motrich RD,Rivero VE

更新日期：2020-07-01 00:00:00

abstract：AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...

journal_title：Immunology letters

authors： Yan J,Jia R,Song H,Liu Y,Zhang L,Zhang W,Wang Y,Zhu Y,Yu J

更新日期：2009-09-22 00:00:00

abstract：:In this study, we examined the cytokine production by human peripheral blood mononuclear cells (PBM) from recipients of orthotopic liver transplants which had been stimulated by donor-specific alloantigen. Levels of interleukin (IL)-2, IL-4, interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta produ...

journal_title：Immunology letters

authors： Chung SW,Yoshida EM,Cattral MS,Hu Y,Gorczynski RM

更新日期：1998-09-01 00:00:00

abstract：:Human deficiency in transporter associated with antigen processing (TAP) is characterized by a very low surface expression of human leukocyte antigen (HLA) class I molecules in hematopoietic and non hematopoietic cells. Among the latter, TAP-deficient skin fibroblasts have previously been shown by us to be very sensit...

journal_title：Immunology letters

authors： Zimmer J,Poli A,Andrès E,Hanau D,Brons NH,Hentges F

更新日期：2006-11-15 00:00:00

abstract：:Stress stimuli affect the immune system responses that occur at mucosal membranes, particularly IgA secretion. It has been suggested that acute stress increases the levels of IgA and that sympathetic innervation plays an important role in this process. We herein explore in a murine model how acute stress affects the T...

journal_title：Immunology letters

authors： Gutiérrez-Meza JM,Jarillo-Luna RA,Rivera-Aguilar V,Miliar-García A,Campos-Rodríguez R

更新日期：2017-08-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....

journal_title：Immunology letters

authors： Ryu JG,Lee J,Kim EK,Seo HB,Park JS,Lee SY,Moon YM,Yoo SH,Park YW,Park SH,Cho ML,Kim HY

更新日期：2015-02-01 00:00:00

abstract：:Using the method of estimation of alpha-helical and beta-folded types of secondary structure from amino acid composition, it has been established that interferons contain about 60-70% of alpha-helices and not more than 10-20% of beta-structure. The same result was obtained using empirical and stereochemical rules for ...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1982-01-01 00:00:00

abstract：:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...

journal_title：Immunology letters

authors： Harfst E,Andersson J,Grawunder U,Ceredig R,Rolink AG

更新日期：2005-11-15 00:00:00

abstract：:The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...

journal_title：Immunology letters

authors： Antas PR,Pedro TQ,Santiago EA,Lima JR,Silva FC,Melca LA,Ponte CG

更新日期：2016-02-01 00:00:00

abstract：:Genetic or DNA-based immunization, including genomic immunization, has shown to be a viable alternative approach to induce protective immunity against a number of pathogens in several disease models. Here we describe a new method, cDNA expression library immunization (cDELI), based on the use of a large number of cDNA...

journal_title：Immunology letters

authors： Manoutcharian K,Terrazas LI,Gevorkian G,Govezensky T

更新日期：1998-07-01 00:00:00

abstract：:IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic r...

journal_title：Immunology letters

authors： Yasukawa K,Futatsugi K,Saito T,Yawata H,Narazaki M,Suzuki H,Taga T,Kishimoto T

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Integrin αvβ6 can convert the transforming growth factor (TGF)-β precursor to the mature form. Resiquimod (R848) can generate TGF-β-producing regulatory T cells (Treg). Thus, to concurrent administration of specific antigen and R848 may generate antigen-specific Tregs, that is expected to restore immune tole...

journal_title：Immunology letters

authors： Ma F,Zhang YY,Yang G,Mo LH,Liu DB,Yang LT,Liu ZG,Ning Y,Yang PC

更新日期：2021-02-01 00:00:00

abstract：:Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...

journal_title：Immunology letters

authors： Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin G

更新日期：1990-08-01 00:00:00

abstract：:Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory...

journal_title：Immunology letters

authors： Shao W,Chen J,Dai H,Peng Y,Wang F,Xia J,Thorlacius H,Zhu Q,Qi Z

更新日期：2011-08-30 00:00:00

abstract：:HLA class II molecules play pivotal roles in antigen presentation to CD4+ T cells. We investigated signaling via HLA-DR molecules expressed on CD4+ T cells. When HLA-DR or CD3 molecules on cloned CD4+ T cells were cross-linked by solid-phase mAbs, T cells proliferated, and this resulted in anergy. Whereas cross-linkin...

journal_title：Immunology letters

authors： Kudo H,Matsuoka T,Mitsuya H,Nishimura Y,Matsushita S

更新日期：2002-04-22 00:00:00

abstract：:Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...

journal_title：Immunology letters

authors： Carrington M,Nelson G,O'Brien SJ

更新日期：2001-11-01 00:00:00

abstract：:In this study the effect of PHA activation on the phosphatase activity of CD45 has been investigated in human leukemic T-cell lines. It has been found that in vivo activation of the cells with PHA resulted in 2-4-fold increase in enzyme activity. Addition of PHA to the postnuclear supernatant of cell lysates also resu...

journal_title：Immunology letters

authors： Monostori E,Hartyani Z,Ocsovszky I,Hegedus Z,Oravecz T,Kalman M,Ando I

更新日期：1994-10-01 00:00:00

abstract：:Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role ...

journal_title：Immunology letters

authors： Rezende SA,Gollob KJ,Correa-Oliveira R,Goes AM

更新日期：1998-06-01 00:00:00

abstract：INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...

journal_title：Immunology letters

authors： Chen Y,McKenna GJ,Ong C,Mui AL,Chung SW

更新日期：2002-04-01 00:00:00

abstract：:Tuberculosis is an infectious disease that affects millions of people worldwide with an annual mortality rate of 1.3 million. The mechanisms contributing to the loss of balance of immune responses and progression to active tuberculosis disease are unknown. Although CD4+ and CD8+ T cells and the cytokines they produce ...

journal_title：Immunology letters

authors： Silva BDS,Trentini MM,da Costa AC,Kipnis A,Junqueira-Kipnis AP

更新日期：2014-07-01 00:00:00

abstract：:Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...

journal_title：Immunology letters

authors： Ribatti D

更新日期：2017-10-01 00:00:00

abstract：:Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

journal_title：Immunology letters

authors： Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...

journal_title：Immunology letters

authors： Yen JH,Tsai WC,Chen CJ,Lin CH,Ou TT,Hu CJ,Liu HW

更新日期：2003-08-05 00:00:00

abstract：:There is increasing evidence for the role of basophils in allergic bronchial asthma. We studied the potential role of basophils in the pathogenesis of post-exercise-induced bronchoconstriction by measuring the histamine release from basophils both spontaneously and following ConA, FMLP, anti-IgE and TPA treatment. Two...

journal_title：Immunology letters

authors： Kivity S,Schwarz I,Agami O,Topilsky M,Fireman E

更新日期：1994-09-01 00:00:00

abstract：:Many types of cells in the immune system have been found to produce nitric oxide (NO), which performs multiplex functions. However, in myelin basic protein peptide 68-86 (MBP 68-86)-induced experimental autoimmune encephalomyelitis (EAE) in Lewis rats, we found that elevated NO production was generated from spleen cel...

journal_title：Immunology letters

authors： Xu L,Yang J,Huang Y,van der Meide PH,Levi M,Wahren B,Link H,Xiao B

更新日期：2000-03-01 00:00:00

abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...

journal_title：Immunology letters

authors： Hildgartner A,Wilflingseder D,Gassner C,Dierich MP,Stoiber H,Bánki Z

更新日期：2009-09-22 00:00:00

abstract：:This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...

journal_title：Immunology letters

authors： Blackwell JM,Roach TI,Atkinson SE,Ajioka JW,Barton CH,Shaw MA

更新日期：1991-10-01 00:00:00

abstract：:T helper17 (Th17) cells have been demonstrated to participate in the pathogenesis of hepatitis B virus (HBV) associated liver damage. However, the contribution of Th17 cells to immune activation and disease aggravation in patients with HBV infection is not fully clear. In this study, we investigated the Th17 cells fre...

journal_title：Immunology letters

authors： Yang B,Wang Y,Zhao C,Yan W,Che H,Shen C,Zhao M

更新日期：2013-01-01 00:00:00