Abstract：
:Stress stimuli affect the immune system responses that occur at mucosal membranes, particularly IgA secretion. It has been suggested that acute stress increases the levels of IgA and that sympathetic innervation plays an important role in this process. We herein explore in a murine model how acute stress affects the Th1/Th2/Treg cytokine balance in NALT, and the possible role of glucocorticoids in this effect. Nine-week-old male CD1 mice were divided into three groups: unstressed (control), stressed (subjected to 4h of immobilization), and stressed after pretreatment with a single dose of the corticosterone receptor antagonist RU-486. The parameters evaluated included plasma corticosterone and epinephrine, IgA levels in nasal fluid (by ELISA), the percentage of CD19+B220+IgA+ lymphocytes and CD138+IgA+ plasma cells, and the mRNA expression of heavy α chain, J chain and pIgR. Moreover, the gene and protein expression of Th1 cytokines (TNFα, IL-2 and INF-γ), Th2 cytokines (IL-4 and IL-5) and Treg cytokines (IL-10 and TGFβ) were determined in nasal mucosa. The results show that acute stress generated a shift towards the dominance of an anti-inflammatory immune response (Th2 and Treg cytokines), evidenced by a significant rise in the amount of T cells that produce IL4, IL-5 and IL-10. This immune environment may favor IgA biosynthesis by CD138+IgA+ plasma cells, a process mediated mostly by glucocorticoids.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Gutiérrez-Meza JM,Jarillo-Luna RA,Rivera-Aguilar V,Miliar-García A,Campos-Rodríguez Rdoi
10.1016/j.imlet.2017.04.016subject
Has Abstractpub_date
2017-08-01 00:00:00pages
68-78eissn
0165-2478issn
1879-0542pii
S0165-2478(17)30196-7journal_volume
188pub_type
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journal_title：Immunology letters
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doi：10.1016/s0165-2478(97)00140-5
更新日期：1998-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-2478(96)02519-9
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更新日期：1986-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1991-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00243-2
更新日期：2003-02-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2020-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90072-x
更新日期：1990-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-2478(87)90098-8
更新日期：1987-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.04.015
更新日期：2004-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.imlet.2006.11.004
更新日期：2007-01-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.12.003
更新日期：2008-03-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.imlet.2010.09.016
更新日期：2011-01-30 00:00:00
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更新日期：2013-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90093-7
更新日期：1983-03-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90092-3
更新日期：1992-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(90)90040-w
更新日期：1990-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00049-7
更新日期：1997-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.03.008
更新日期：2007-05-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00014-5
更新日期：1998-04-01 00:00:00
