Abstract:
:Stimulation of tonsillar B-lymphocytes with CD40 antibodies and IL-4 leads to homotypic adhesion, proliferation, and differentiation into Ig-producing cells. It also leads to the production of IL-6, a pleiotropic cytokine involved in B-cell maturation and differentiation. To assess the importance of IL-6 in the differentiation process, an antisense oligonucleotide to IL-6 was added to tonsillar B-cells together with CD40 antibodies and IL-4. This led to clearly reduced levels of IL-6 as well as to a specific inhibition of IgE production. Also, IgG secretion was somewhat reduced while IgM appeared to be unaffected. The effects were not due to toxicity of the oligonucleotide since proliferation proceeded normally or was slightly enhanced in the presence of the antisense. The findings show that endogenous IL-6 is an important co-factor for the generation of B-cells secreting IgE and IgG but that it is not required for IgM production. They further indicate that IL-6 may not be necessary as a co-factor in CD40/IL-4 induced proliferation.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Björck P,Larsson S,Andäng M,Ahrlund-Richter L,Paulie Sdoi
10.1016/s0165-2478(97)00140-5subject
Has Abstractpub_date
1998-03-01 00:00:00pages
1-5issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(97)00140-5journal_volume
61pub_type
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