Abstract：
:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as determined by immunoprecipitation. The degree of recognition of the native protein varied between 0.5 and 80%, the most reactive sera being those induced by the terminal peptides. The ability of internal peptides to induce antibodies reactive with native large T antigen appeared to be correlated with peptide hydrophilicity and possibly atomic mobility. No such correlation was apparent with predicted features of secondary structure. The influence of peptide length on induction of protein-recognizing antisera will also be discussed.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Friedrich U,Scheidtmann KH,Walter Gdoi
10.1016/0165-2478(86)90006-4subject
Has Abstractpub_date
1986-04-01 00:00:00pages
207-15issue
4eissn
0165-2478issn
1879-0542pii
0165-2478(86)90006-4journal_volume
12pub_type
杂志文章abstract：:The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.12.004
更新日期：2016-02-01 00:00:00
abstract：:The aim of this work was to raise allotype specific monoclonal antibodies to human CD45, with the long-term objective of producing a reagent which could be used to prolong graft survival in renal transplantation through removal of passenger leukocytes from the graft. At present there are no anti-CD45 monoclonal antibo...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00056-5
更新日期：1999-06-01 00:00:00
abstract：:Phagocytosis of latex beads by peritoneal macrophages was examined by means of flow cytometry (FCM). This assay revealed that adrenocorticotropic hormone (ACTH) suppressed phagocytosis in a dose-dependent manner. ACTH (1-24) was more suppressive than ACTH (1-39). Control phagocytosis was partially suppressed in Ca(2+)...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90080-9
更新日期：1994-10-01 00:00:00
abstract：:When human peripheral blood lymphocytes (PBL) are cultured with either concanavalin A (Con A)-treated or control autologous T lymphocytes, the mitogenic responses of the PBL co-cultured with Con A-treated cells are much lower. We have investigated the cell surface receptor changes during culture of T cells with and wi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90031-2
更新日期：1984-01-01 00:00:00
abstract：:H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90111-0
更新日期：1982-11-01 00:00:00
abstract：:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90086-1
更新日期：1987-01-01 00:00:00
abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00085-j
更新日期：1995-07-01 00:00:00
abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.11.002
更新日期：2010-01-18 00:00:00
abstract：:Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...
journal_title：Immunology letters
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:CD27, which belongs to the TNF receptor family, is a costimulatory molecule that participates in T-cell activation. Unlike costimulatory molecules such as OX40 and 4-1BB, little is known about the role CD27 plays a role in the development of experimental diseases. We asked whether CD27 and its ligand CD70 participate ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.05.004
更新日期：2008-08-15 00:00:00
abstract：:The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90096-9
更新日期：1986-03-01 00:00:00
abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.03.003
更新日期：2016-05-01 00:00:00
abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90085-3
更新日期：1984-01-01 00:00:00
abstract：:Psoriasis and psoriatic arthritis (PsA) are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises a dysfunctional stromal-immune cell and cytokine network leading to inflammation of skin, entheses and joints. Recent advances in understanding of disease pathogenesis have...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.08.009
更新日期：2007-12-15 00:00:00
abstract：:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heteroge...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90177-5
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the curre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.005
更新日期：2019-08-01 00:00:00
abstract：:The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytomet...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90126-0
更新日期：1989-12-01 00:00:00
abstract：:As a cytokine adjuvant, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been demonstrated to play central roles in the enhancement of the immune response and protection elicited by experimental vaccines. However, in our previous work, the co-administration of GM-CSF produced untoward effects on the immun...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.08.005
更新日期：2014-11-01 00:00:00
abstract：:This study aimed to investigate the influence of physical activity in innate immunity to conduce to an effective antitumoral immune response analyzing the phenotype and activation status of infiltrating cells. We analysed the intracellular cytokines and the transcription factors of tumor infiltrating lymphocytes (TILS...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.08.007
更新日期：2017-10-01 00:00:00
abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(03)00029-4
更新日期：2003-05-01 00:00:00
abstract：:A novel mutant strain of rats, LEC, exhibits an arrest of T-cell maturation from CD4+CD8+ to CD4+CD8- but not the CD4-CD8+ cells in the thymus. Nevertheless, CD4+T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell rece...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00254-o
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:Notch pathway is highly conserved across species and is involved in the regulation of cell differentiation and activity both in embryonic development and adult life. Notch signaling has an important role in the development of hematopoietic stem cells and their differentiation to committed lineages, as well a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.04.010
更新日期：2020-07-01 00:00:00
abstract：:The production of interleukin 1 (IL-1) by lipopolysaccharide (LPS)-stimulated myelomonocytic cell lines ML-1, THP-1 and PL-21 was significantly enhanced by the addition of insulin, insulin-like growth factor (IGF)-I or IGF-II into the cell cultures. The IL-1 activity in the supernatants from cell cultures stimulated w...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90220-i
更新日期：1992-12-01 00:00:00
abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:The induction characteristics of major histocompatibility complex (MHC) class I-specific cytotoxic T lymphocytes (CTL) after footpad immunization were studied. Primary CTL were generated in the regional lymph nodes of C57Bl/6 mice by footpad injection with 10(7) irradiated (2000 rad) spleen cells from MHC class I muta...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90073-6
更新日期：1994-10-01 00:00:00
abstract：:We infected umbilical cord blood lymphocytes (CBL) with EBV in vitro. Analysis of the cell population in 3- and 6-day-old cultures showed a relative increase of B cells and outgrowth of B cells after prolonged culture period. The immunomodulator PSK was added to parallel cultures. In these cultures, B cell growth was ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00330-3
更新日期：2002-03-01 00:00:00
abstract：:Inflammation elicits an acute phase response, which includes changes in plasma concentrations of a number of cytokines, reflecting changes in their gene transcription in the liver. In this study, the induction of complement factor 3 (C3) was investigated in HepG2 cells, a human hepatoma cell line often used as a model...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00180-8
更新日期：2001-03-01 00:00:00
abstract：:The contribution of T cell precursors from the thymus and the bone marrow to the pool of intestinal intraepithelial lymphocvtes (IELs) has been studied in a system using donor cells from enhanced-green fluorescent protein (EGFP+ ) transgenic mice a doptively transferred into EGFP- recipient mice. Consistent with previ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00275-3
更新日期：2000-12-01 00:00:00
abstract：:Myelin basic protein (MBP), is a major component of the central nervous system (CNS) myelin. MBP can stimulate T cells that migrate into the CNS, initiating a cascade of events that result in perivascular infiltration and demyelination. EAE is an inflammatory and demyelinating autoimmune disease of the CNS that serves...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00089-9
更新日期：1999-06-01 00:00:00
abstract：:A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic ori...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(02)00024-x
更新日期：2002-06-03 00:00:00
