Abstract：
:Isolated inherited deficiency states of almost every complement protein have been recognized. Almost all are autosomal recessive traits. Deficiency of the early-acting components C1, C4 and C2 is associated with increased risk of immune complex disease, particularly systemic lupus erythematosus. Patients with deficiency of C3, factor I or factor H have increased susceptibility to infection by pyogenic bacteria, whereas those with deficiencies of properdin, C5, C6, C7 or C8 are prone to systemic neisserial infection. Inherited deficiency of C1 inhibitor is transmitted as an autosomal dominant trait, is genetically heterogeneous, and is associated with attacks of angioedema and consumption of C4 and C2. There is evidence that a plasmin-modified fragment of C2 is responsible for the angioedema in this disorder. Administration of androgens tends to correct the biochemical abnormalities of hereditary angioedema and to prevent attacks.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Alper CAdoi
10.1016/0165-2478(87)90098-8subject
Has Abstractpub_date
1987-02-01 00:00:00pages
175-81issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(87)90098-8journal_volume
14pub_type
杂志文章abstract：:Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropher...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.011
更新日期：2016-06-01 00:00:00
abstract：:Cell-surface 5'-nucleotidase was assayed by incubating intact cells with 5' [3H]AMP in iso-osmotic buffer and measuring [3H]adenosine production. The activity of cell surface 5'-nucleotidase in small resting lymphocytes and in cells of the B cell line BCL1 was 5.7 and 1.1 nmol/min/mg protein respectively at 37 degrees...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90122-8
更新日期：1988-09-01 00:00:00
abstract：:In murine models, challenge with different viral and parasitic infection is closely associated with the production of type I interferons (IFN-alpha/beta) and NK cell production of interferon-gamma (IFN-gamma). Therefore, we wished to determine if IFN-alpha/beta had a role in the regulation of NK cell production of IFN...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00091-6
更新日期：1997-10-01 00:00:00
abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90051-5
更新日期：1994-06-01 00:00:00
abstract：:Tumor cells express a range of antigens including self-antigens (those whose expression is shared by normal host tissue) and non-self antigens (such as those that arise as a result of mutations in normal cellular genes or in the case of some tumors, viral antigens). Immune responses to both types of antigen have been ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(02)00240-7
更新日期：2003-01-22 00:00:00
abstract：:Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...
journal_title：Immunology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.imlet.2019.03.003
更新日期：2019-09-01 00:00:00
abstract：:Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-va...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(02)00159-1
更新日期：2002-11-01 00:00:00
abstract：:Antisera were raised in rabbits against a monoclonal antibody (McAb 103) of C3H.SW origin which is specific to the synthetic polypeptide (T,G)-A-L and was shown to express the major idiotypic determinants of conventional anti-(T,G)-A-L antibodies. Antibodies were purified and were shown in a binding assay to recognize...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90130-0
更新日期：1985-01-01 00:00:00
abstract：:Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(01)00275-9
更新日期：2001-11-01 00:00:00
abstract：:Multiple antigen peptides (MAP), consisting of a number of peptide copies synthesized on a branching lysyl core, offer a novel approach for rendering small peptides immunoreactive in solid-phase immunoassays. An octameric MAP, carrying 6 repeats of the sequence -N-A-A-G-, tandem repeated in the immunodominant region o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90092-o
更新日期：1991-09-01 00:00:00
abstract：:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90086-1
更新日期：1987-01-01 00:00:00
abstract：:The effects of recombinant human interleukin 4 (rIL-4) on proliferation and differentiation on human myeloid/monocytic leukemia cell lines were examined. At high concentrations, rIL-4 had a slight enhancing effect on [3H]thymidine incorporation by U937 cells. rIL-4 markedly induced expression of the Fc epsilon recepto...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90027-8
更新日期：1989-06-15 00:00:00
abstract：:We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.11.007
更新日期：2010-01-18 00:00:00
abstract：:Inflammation elicits an acute phase response, which includes changes in plasma concentrations of a number of cytokines, reflecting changes in their gene transcription in the liver. In this study, the induction of complement factor 3 (C3) was investigated in HepG2 cells, a human hepatoma cell line often used as a model...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00180-8
更新日期：2001-03-01 00:00:00
abstract：:DNA-dependent RNA polymerase was partially purified from wheat germ extract and tested for inhibition by antinuclear autoantibodies from the sera of patients with connective tissue diseases. The enzyme was inhibited by anti-DNA and by autoantibodies to the nuclear ribonucleoprotein nRNP. Autoantibodies to other ribonu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90093-7
更新日期：1983-03-01 00:00:00
abstract：:Control animals and rats infected 90 days earlier, by inoculation of 1 x 10(6) trypomastigotes of Trypanosoma cruzi at weaning, were subjected to adult thymectomy (ATx) or sham operation (S-ATx) and assessed 3 months later for the presence of myocardial lesions and levels of lymph node and spleen T-cell populations. C...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90028-z
更新日期：1993-08-01 00:00:00
abstract：:N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.06.005
更新日期：2016-09-01 00:00:00
abstract：:Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90040-x
更新日期：1987-06-01 00:00:00
abstract：:We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00153-3
更新日期：1998-02-01 00:00:00
abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.11.002
更新日期：2010-01-18 00:00:00
abstract：:Yolkin is a product of proteolytic degradation of vitellogenin, a protein contained in eggs' yolk, with already described procognitive properties. Here, we investigated effects of yolkin on the humoral and cellular immune response in mice, phenotype of cells from lymphoid organs and function of innate immunity cells. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.01.003
更新日期：2020-04-01 00:00:00
abstract：:Tumor cells have been used as the tumor antigen sources for developing cancer vaccines. Due to their low immunogenicity, tumor antigens are combined with various adjuvants to enhance immunogenicity of cancer vaccines. Among them, a natural killer T cell (NKT)-ligand, α-galactosylceramide (αGC) has been reported as a p...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.10.002
更新日期：2013-11-01 00:00:00
abstract：:RASI-1 is a novel matrix metalloproteinase which we isolated from an expression cDNA library representing the mRNA of an inflamed synovium obtained from a patient with rheumatoid arthritis (RA). To investigate the involvement of RASI-1 in the pathology of RA, we examined synovial specimens from RA patients with antibo...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00057-6
更新日期：1997-06-01 00:00:00
abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90069-2
更新日期：1989-01-15 00:00:00
abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the selective destruction of the insulin-producing β cells. Research into the pathogenesis of T1D has been hindered by the lack of detection of the autoimmune process during the asymptomatic period and by the inaccessibility to the target tissue. Therefore curre...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2010.08.001
更新日期：2010-10-30 00:00:00
abstract：:Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00290-0
更新日期：2003-03-03 00:00:00
abstract：BACKGROUND:CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.01.007
更新日期：2020-04-01 00:00:00
abstract：:Heat-killed Saccharomyces cerevisiae (HKSC) is an agonist for Dectin-1, a major fungal cell wall β-glucan receptor. We previously reported that HKSC selectively enhances IgG1 production by LPS-activated mouse B cells. To determine if this IgG1 selectivity is caused by selective IgG1 class switching, we performed RT-PC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.08.010
更新日期：2016-10-01 00:00:00
abstract：:The role of the immunomodulator Protein A (PA) (from Staphylococcus aureus, Cowan I strain) in the control of leishmanial infection was studied in experimental animals. Treatment of Leishmania donovani infected hamsters with PA led to a moderate level of reduction of parasite load in their spleen (68%) and liver (46%)...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00102-3
更新日期：1999-02-01 00:00:00
abstract：:The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2009.12.009
更新日期：2010-05-04 00:00:00
