Abstract:
:Control animals and rats infected 90 days earlier, by inoculation of 1 x 10(6) trypomastigotes of Trypanosoma cruzi at weaning, were subjected to adult thymectomy (ATx) or sham operation (S-ATx) and assessed 3 months later for the presence of myocardial lesions and levels of lymph node and spleen T-cell populations. Chronic focal myocarditis (CFM) developed in 78% and 84% of S-ATx or ATx infected rats, respectively. While the two groups of infected rats did not differ as to the occurrence of myocardial lesions, large foci of CFM were more prevalent in ATx infected rats. Chronic T. cruzi (Tc) infection resulted in decreased CD4+ and increased CD8+ lymph node and spleen cell, with CD8+ lymphocytes being lowered to normal values in the spleen of the ATx infected group. It is suggested that ATx might act by interfering with a down-regulating immunoregulatory mechanism, leading to an exacerbation of autoimmune reactions believed to be involved in the generation of myocardial damage.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bottasso OA,Revelli SS,Dávila H,Valenti JL,Musso OC,Ferro ME,Romero-Piffiguer M,Morini JCdoi
10.1016/0165-2478(93)90028-zsubject
Has Abstractpub_date
1993-08-01 00:00:00pages
175-80issue
2-3eissn
0165-2478issn
1879-0542pii
0165-2478(93)90028-Zjournal_volume
37pub_type
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