Abstract:
:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on adaptive immunity. Loss of TLR5 has profound effects on the microbiota that include greater temporal instability of major lineages and upregulation of flagellar motility genes that may be linked to the reduced levels of anti-flagellin antibodies in the TLR5(-/-) host. A variety of human TLR5 gene alleles exist that also associated with inflammatory conditions and may do so via effects on the gut microbiome and altered host-microbial crosstalk.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Leifer CA,McConkey C,Li S,Chassaing B,Gewirtz AT,Ley REdoi
10.1016/j.imlet.2014.07.017subject
Has Abstractpub_date
2014-12-01 00:00:00pages
3-9issue
2 Pt Aeissn
0165-2478issn
1879-0542pii
S0165-2478(14)00207-7journal_volume
162pub_type
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