Abstract：
:Among tumor necrosis factor (TNF) superfamily, TNF-related apoptosis inducing ligand (TRAIL) along with TNF-alpha and FasL is known as death ligand due to its selective cytotoxicity against transformed tumor cells. TRAIL can also induce alternative angiogenic and/or proinflammatory signals other than apoptosis, however, the molecular mechanisms responsible for the alternative signals have not been detailed yet. Intercellular adhesion molecule-1 (ICAM-1) is thought to be involved in the processes of metastasis and angiogenesis in various tumors. We investigated the molecular mechanisms responsible for ICAM-1 expression by death ligands in human astroglial cells to delineate the alternative signals of these ligands. Here, we demonstrate that (1) death ligands induced expression of ICAM-1 at the mRNA and protein levels in human astroglial cells; (2) pre-treatment of z-VAD-fmk and/or SB202190 suppressed death ligand-induced ICAM-1 expression and subsequent adhesion of activated monocytic cells; and (3) inhibition of caspase suppressed death ligand-induced phosphorylation of p38 MAPK and IKK. These findings suggest biological function of death receptors other than apoptosis in human astroglial cells, and the involvement of caspase and/or p38 MAPK in alternative signaling through death receptors.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Choi K,Song S,Choi Cdoi
10.1016/j.imlet.2008.01.010subject
Has Abstractpub_date
2008-05-15 00:00:00pages
168-73issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(08)00038-2journal_volume
117pub_type
杂志文章abstract：BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...
journal_title：Immunology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.imlet.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:To study the mechanism(s) responsible for the appearance of Epstein-Barr virus (EBV)-induced anti-histone autoantibodies, peripheral blood B lymphocytes from healthy donors were infected with EBV and the resulting lymphoblastoid cell lines were tested for secretion of antibodies reacting with histones. It was found th...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90169-4
更新日期：1994-03-01 00:00:00
abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00117-5
更新日期：1999-01-01 00:00:00
abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.11.001
更新日期：2009-01-29 00:00:00
abstract：:Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2010.01.007
更新日期：2010-03-10 00:00:00
abstract：:Heat-sensitive serum masking cofactor(s) of antiphospholipid antibody (aPL) in normal human sera (NHS) are specifically inactivated at 56 degrees C. The degree of binding in ELISA by unmasked aPL in NHS was equivalent to that in non-heated, aPL-reactive autoimmune SLE sera. Previously "negative" SLE sera also reacted ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90189-w
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Notch pathway is highly conserved across species and is involved in the regulation of cell differentiation and activity both in embryonic development and adult life. Notch signaling has an important role in the development of hematopoietic stem cells and their differentiation to committed lineages, as well a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.04.010
更新日期：2020-07-01 00:00:00
abstract：:Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.02.008
更新日期：2017-04-01 00:00:00
abstract：:Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephe...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02522-9
更新日期：1996-05-01 00:00:00
abstract：:Humanized mouse models present an important tool for preclinical evaluation of new vaccines and therapeutics. Here we show the human variable repertoire of antibody sequences cloned from a previously described human immune system (HIS) mouse model that possesses functional human CD4+ T cells and B cells, namely HIS-CD...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.06.001
更新日期：2017-08-01 00:00:00
abstract：:Pentoxifylline (PTX), a methylxanthine derivative and phosphodiesterase inhibitor, is known to influence production and/or function of some cytokines. We examined the effect of PTX on the in vitro expression of cytokine genes using endotoxin- or phytohaemagglutinin (PHA)-stimulated human blood mononuclear cells. The e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90022-t
更新日期：1993-08-01 00:00:00
abstract：:Modulation of the IgE response by PHA treatment in relation to animal sex was analysed. Male and female RF mice were immunized with ovalbumin in aluminum hydroxide gel and PHA was injected 1 or 2 days before immunization. Castrated mice were also immunized and received PHA on day -2. The results show that the IgE resp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90056-3
更新日期：1987-10-01 00:00:00
abstract：:Natural anti-cholesterol antibodies (ACHAs) exist in mammalian species, moreover their level sensitively changes in pathological situations, such as atherosclerosis or HIV infection. The conditions of their production and functional role, however, still remained ill defined. Recently we developed IgG3 type monoclonal ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.01.009
更新日期：2012-03-30 00:00:00
abstract：:In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90067-z
更新日期：1990-02-01 00:00:00
abstract：:Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying vi...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2011.06.008
更新日期：2011-12-30 00:00:00
abstract：:A murine monoclonal antibody (IgG) has been generated that binds to DNA modified with osmium tetroxide in the presence of 2,2'-bipyridine and does not interact with unmodified DNA. Reactivity of the antibody was tested by gel retardation assay, ELISA, dot-binding assay and immunoblotting. The results obtained suggest ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90084-n
更新日期：1991-09-01 00:00:00
abstract：:Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages. In this report we have examined the effect of the in vivo administration of adrenaline on TNF serum levels induced by LPS. In agre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90177-4
更新日期：1993-10-01 00:00:00
abstract：:To examine whether grape seed proanthocyanidin extract (GSPE) which is known to act as an antioxidant has therapeutic effect on collagen-induced arthritis (CIA) in mice, an animal model of rheumatoid arthritis. Mice were treated with an intraperitoneal injection of GSPE (10, 50, or 100 mg/kg) or saline. Clinical, hist...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.05.001
更新日期：2009-06-04 00:00:00
abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.05.002
更新日期：2015-07-01 00:00:00
abstract：:The production of neutralizing antibodies against the central portion of HIV-1 gp120 requires cooperation between T cell and B cell epitopes of this region. We found a motif common to the carboxyterminus of the second conserved region of HIV-1 gp120 and sequences of some human proteins, most of which participate in im...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90145-g
更新日期：1990-11-01 00:00:00
abstract：:Angiogenic and poorly angiogenic tumor variants were obtained by an intraperitoneal inoculation of cells from clones of polyoma-virus transformed BALB/c 3T3 cells into syngeneic mice. The angiogenic tumor cells expressed a higher tumorigenicity phenotype and a higher capacity to produce artificial pulmonary metastases...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02675-2
更新日期：1996-12-01 00:00:00
abstract：:The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2008.06.002
更新日期：2008-08-15 00:00:00
abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90011-c
更新日期：1992-01-01 00:00:00
abstract：:Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.05.001
更新日期：2003-10-31 00:00:00
abstract：:In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and other proinflammatory mediators of joint d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.001
更新日期：2016-06-01 00:00:00
abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90069-2
更新日期：1989-01-15 00:00:00
abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.017
更新日期：2014-12-01 00:00:00
abstract：:We have previously reported that the capacity of highly malignant B16BL6 murine melanoma cells to induce cell death in naive syngeneic lymphocytes stems from the absence of major histocompatibility complex (MHC) class I glycoproteins in these melanoma cells. Our present study provides evidence that the above-mentioned...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.03.016
更新日期：2005-09-15 00:00:00
abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90090-7
更新日期：1984-01-01 00:00:00
abstract：UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.03.018
更新日期：2004-05-15 00:00:00
