Abstract：
:Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying viewpoint. With time, important functional affinities but also substantial diversities were recognized. This review article focuses on the historical development of the concept of mast cell/basophil specificity, from the initial identification of these cells to current studies.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Crivellato E,Nico B,Ribatti Ddoi
10.1016/j.imlet.2011.06.008subject
Has Abstractpub_date
2011-12-30 00:00:00pages
10-7issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(11)00180-5journal_volume
141pub_type
历史文章,杂志文章,评审abstract：:The complement system is a protein cascade capable of neutralizing invading pathogens. One of its activation pathways is the lectin pathway which is dependent on the binding of MBL or the ficolins. The specificity of L-ficolin binding has been investigated previously and it was observed that binding is dependent on ac...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.014
更新日期：2008-06-30 00:00:00
abstract：:Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90155-6
更新日期：1987-12-01 00:00:00
abstract：:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90006-4
更新日期：1986-04-01 00:00:00
abstract：:It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.08.018
更新日期：2005-01-31 00:00:00
abstract：:Age-related changes of different individuals multicentric and polymorphic. We have approached this problem of age-related changes by examining (1) membrane densities of receptors of various ligands in different organs, and (2) changes in different classes of T cells and of antibody response. Three strategies have been...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(87)90147-7
更新日期：1987-12-01 00:00:00
abstract：:Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.05.010
更新日期：2017-09-01 00:00:00
abstract：:Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2017.07.014
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. orientale, respectively)...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.009
更新日期：2018-09-01 00:00:00
abstract：:Circulating lymphocytes were enumerated in 25 patients with coeliac disease and in 24 healthy donors by immunofluorescent staining using monoclonal antibodies for T cell surface phenotypic markers T11 (mature), T4 (helper) and T8 (suppressor) or polyvalent antisera for surface immunoglobulins (B cells). Proportions of...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90119-7
更新日期：1986-08-01 00:00:00
abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title：Immunology letters
pub_type： 撤回出版物
doi：10.1016/j.imlet.2017.08.015
更新日期：2017-08-26 00:00:00
abstract：:Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2010.01.007
更新日期：2010-03-10 00:00:00
abstract：:The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.06.005
更新日期：2012-09-01 00:00:00
abstract：:The cellular source of murine LAIF detected by an indirect leukocyte adherence inhibition (LAI) assay using capillary tubes was investigated using non-inducing peritoneal cells (PC) from normal and spindle-cell sarcoma-bearing A/J mice. Cell populations containing greater than 95% T-cells, B-cells or macrophages were ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90005-5
更新日期：1981-11-01 00:00:00
abstract：:Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.12.002
更新日期：2006-05-15 00:00:00
abstract：:Foxp3+ Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self. Therefore, it is expected that lower numbers and/or less than optimal function could impact on the functioning of the immune system, and thereby contributing to the development of autoimmune diseases. In the present report, by co...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.04.006
更新日期：2020-07-01 00:00:00
abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.10.008
更新日期：2012-01-30 00:00:00
abstract：:Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk factor for child type 1 diabetes mellitus development. To test the role of IL-18 gene polymorphism in predisposition to adult type 1 diabetes (T1DM) and latent autoimmune diabetes in adults (LADA), we analysed SNPs at position -607 (C/A) and ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.08.016
更新日期：2005-01-31 00:00:00
abstract：:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00034-5
更新日期：1997-07-01 00:00:00
abstract：:Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2007.12.003
更新日期：2008-03-15 00:00:00
abstract：:T-cell immunoglobulin mucin-1 (TIM-1) is associated with the regulation of T helper type 2 (Th2) immune responses and has been associated with asthma susceptibility. Previous studies have shown that administration of TIM-1 results in T cell hyperproliferation and increased Th2 cytokine secretion. TIM-1 has also been s...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.11.004
更新日期：2007-01-15 00:00:00
abstract：:The T cell receptor of gamma delta is normally expressed on a small percentage of peripheral lymphocytes. Although the role of gamma delta T cells in the physiologic immune response is still unknown, there is accumulating evidence that gamma delta T cells may participate in the immune response to mycobacterial and oth...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90105-y
更新日期：1990-08-01 00:00:00
abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.10.011
更新日期：2018-09-01 00:00:00
abstract：:The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.015
更新日期：2014-12-01 00:00:00
abstract：:Two chicken monoclonal antibodies (MAbs), HU/Ch2-7 and HU/Ch6-1, against heterophil Hanganutziu-Deicher (HD) antigens with N-glycolylneuraminic acid (NeuGc) at a terminal carbohydrate were established by cell fusions using chicken B cell lines lacking thymidine kinase and spleen cells from chickens immunized with II3N...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90205-3
更新日期：1992-03-01 00:00:00
abstract：:At least three B cell subsets, B-1a (Ly-1B), B-1b and B-2, are present in the mouse periphery. B-1a and B1-b cells represent a small population in the adult spleen and are abundant in the peritonial and pleural cavities. It has been demonstrated in our laboratory that B-1b cells spontaneously proliferated in stationar...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00266-3
更新日期：2003-03-03 00:00:00
abstract：:Good Syndrome is a rare clinical entity first described as the conjunction of thymoma and hypogammaglobulinemia, and more recently depicted as a complex disease integrating a medical history of thymoma with humoral immunodeficiency (more accurately stated: hypogammaglobulinemia) with or without cellular immunodeficien...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.12.010
更新日期：2021-01-05 00:00:00
abstract：:Psoriasis and psoriatic arthritis (PsA) are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises a dysfunctional stromal-immune cell and cytokine network leading to inflammation of skin, entheses and joints. Recent advances in understanding of disease pathogenesis have...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.08.009
更新日期：2007-12-15 00:00:00
abstract：:The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00156-5
更新日期：2000-04-03 00:00:00
abstract：:Genetic or DNA-based immunization, including genomic immunization, has shown to be a viable alternative approach to induce protective immunity against a number of pathogens in several disease models. Here we describe a new method, cDNA expression library immunization (cDELI), based on the use of a large number of cDNA...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00039-x
更新日期：1998-07-01 00:00:00
abstract：:The immunomodulating properties of a neuropeptide hormone, corticotropin-releasing factor (CRF), led us to investigate its effect on cAMP production by human peripheral blood mononuclear cells (MNC). In response to stimulation with CRF (100 nM), a statistically significant (P = 0.019) increase occurred in the amount o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90189-9
更新日期：1993-03-01 00:00:00
