Abstract：
:Good Syndrome is a rare clinical entity first described as the conjunction of thymoma and hypogammaglobulinemia, and more recently depicted as a complex disease integrating a medical history of thymoma with humoral immunodeficiency (more accurately stated: hypogammaglobulinemia) with or without cellular immunodeficiency, recurrent infections, autoimmunity, paraneoplastic syndromes and diverse aberrations in the immunological profile. This condition has an ominous prognosis with a high mortality rate secondary to recalcitrant infectious diseases. Understanding the possible discordances in clinical presentation and the temporal relationship between manifestations and immunological alterations is key to prevent misdiagnosis and complications. To this end, here we provide two illustrative patients with Good Syndrome that share common clinical manifestations and yet show unique and opposed immunological profiles, thereby highlighting the pivotal interest of a comprehensive immunological profiling in these patients. We conducted a thorough review of existing literature on the elusive molecular mechanisms underlying the syndrome and provide a clinical assessment algorithm to facilitate the management of these challenging patients.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Guevara-Hoyer K,Fuentes-Antrás J,Calatayud Gastardi J,Sánchez-Ramón Sdoi
10.1016/j.imlet.2020.12.010subject
Has Abstractpub_date
2021-01-05 00:00:00pages
11-17eissn
0165-2478issn
1879-0542pii
S0165-2478(20)30438-7journal_volume
231pub_type
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