Abstract:
:Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD28 stimulation leads to recruitment of a beta-arrestin/phosphodiesterase-4 (PDE4) complex to rafts, resulting in down-regulation of cAMP levels. Thus, the activities of both PKA and PDE4 seem to be important for regulation of TCR-induced signaling and T cell function. This review will focus on the novel mechanism whereby CD28 through PI3K regulates recruitment of a PKB/beta-arrestin/PDE4 complex thereby allowing a complete T cell activation to proceed.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bjørgo E,Taskén Kdoi
10.1016/j.imlet.2010.01.007subject
Has Abstractpub_date
2010-03-10 00:00:00pages
1-6issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(10)00037-4journal_volume
129pub_type
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pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00156-9
更新日期:1998-05-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,meta分析,评审
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.03.010
更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Immunology letters
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更新日期:2015-03-01 00:00:00
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