Anti-T-cell receptor therapy in murine experimental systemic lupus erythematosus.

abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...

journal_title：Immunology letters

authors： Haskó G,Elenkov IJ,Vizi ES

更新日期：1995-07-01 00:00:00

abstract：:Two crucial mediators of monocyte activation by lipopolysaccharide (LPS) are the acute phase plasma factor, lipopolysaccharide binding protein (LBP) and cell-surface-expressed CD14. Whether macrophage (M phi) recognized and respond to LPS in a similar manner is unknown. Here we show that human monocyte-derived M phi r...

journal_title：Immunology letters

authors： Jungi TW,Brcic M,Eperon S

更新日期：1996-12-01 00:00:00

abstract：:The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...

journal_title：Immunology letters

authors： Hoffman SL,Weiss W,Mellouk S,Sedegah M

更新日期：1990-08-01 00:00:00

abstract：:Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...

journal_title：Immunology letters

authors： Napoli C,Benincasa G,Criscuolo C,Faenza M,Liberato C,Rusciano M

更新日期：2021-01-06 00:00:00

abstract：:Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three...

journal_title：Immunology letters

authors： Herrera-Maya G,Vargas-Alarcon G,Ramirez-Bello J,Perez-Mendez O,Posadas-Sanchez R,Lopez-Marure R,Granados J,Nieto-Lima B,Fragoso JM

更新日期：2020-12-01 00:00:00

abstract：:The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...

journal_title：Immunology letters

authors： Schreiber HA,Sandor M

更新日期：2010-05-04 00:00:00

abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...

journal_title：Immunology letters

authors： Dittes K,Gakamsky DM,Haran G,Haas E,Ojcius DM,Kourilsky P,Pecht I

更新日期：1994-05-01 00:00:00

abstract：:T cell functions are regulated by multiple signaling cascades, including the MKK4-JNK (c-Jun NH2 terminal kinase) pathway. However, the mechanism regulating the MKK4-JNK axis in T cells remains unclear. Herein, we demonstrated that protein acetylation modulates JNK activity induced by T cell receptor (TCR) activation....

journal_title：Immunology letters

authors： Matsui Y,Kuwabara T,Eguchi T,Nakajima K,Kondo M

更新日期：2018-02-01 00:00:00

abstract：:Among tumor necrosis factor (TNF) superfamily, TNF-related apoptosis inducing ligand (TRAIL) along with TNF-alpha and FasL is known as death ligand due to its selective cytotoxicity against transformed tumor cells. TRAIL can also induce alternative angiogenic and/or proinflammatory signals other than apoptosis, howeve...

journal_title：Immunology letters

authors： Choi K,Song S,Choi C

更新日期：2008-05-15 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...

journal_title：Immunology letters

authors： Muñoz-Fernández MA,Fernández MA,Fresno M

更新日期：1992-06-01 00:00:00

abstract：:The Nramp1 gene was originally described as Ity/Lsh/Bcg, a single gene controlling resistance and susceptibility of inbred mice to a range of intramacrophage pathogens. Functional studies demonstrated that Ity/Lsh/Bcg had multiple pleiotropic effects on macrophage activation pathways, broadening interest in the gene t...

journal_title：Immunology letters

authors： Blackwell JM,Searle S

更新日期：1999-01-01 00:00:00

abstract：:In addition to its hematopoietic activities, interleukin-3 (IL-3) can modulate macrophage functions. We have studied the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the presence or absence of IL-3. Int...

journal_title：Immunology letters

authors： Cohen L,David B,Cavaillon JM

更新日期：1991-05-01 00:00:00

abstract：:Interleukin 18 (IL-18) gene polymorphisms have been reported to be associated with the outcomes of hepatitis C virus (HCV) infection in Americans, Indians and Europeans. We aimed to investigate whether the association can be replicated in Chinese Han population. Three IL-18 variants, -656G>T, -137G>C and +105A>C, were...

journal_title：Immunology letters

authors： Yue M,Wang JJ,Tang SD,Feng L,Zhang Y,Liu Y,Wang J,Deng XZ,Xu K,Zhang J

更新日期：2013-07-01 00:00:00

abstract：:Mimotopes derived from peptide phage display libraries may reproduce basic functions of epitopes including their antigenicity. In case of toxins, this property makes phage displayed mimotopes highly specific vaccine components free of the toxicity. To explore the potential of mimotopes for vaccine development, their a...

journal_title：Immunology letters

authors： Hernández R,Gazarian TG,Hérion PS,Gazarian KG

更新日期：2002-02-01 00:00:00

abstract：:A variety of cell types may be involved in the regulation of IgA secretion at the intestinal mucosa. Intestinal epithelial cells (IEC) are known to have the capacity to secrete several cytokines which may exert an important regulatory effect on local immunoglobulin secretion by mucosal B cells. In this study, we have ...

journal_title：Immunology letters

authors： Goodrich ME,McGee DW

更新日期：1999-03-15 00:00:00

abstract：:Tuberculosis (TB) is a highly infectious disease and its early and precise diagnosis is essential to reduce morbidity and mortality of patients. Since the routine diagnostic tests (like Monteux, AFB smear microscopy, chest X-Ray) do not give infallible results, additional tests are always recommended. Therefore to add...

journal_title：Immunology letters

authors： Tripathi DK,Srivastava K,Nagpal KL,Shukla PK,Srivastava KK

更新日期：2019-05-01 00:00:00

abstract：:The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...

journal_title：Immunology letters

authors： Bharti AC,Singh SM

更新日期：2000-04-03 00:00:00

abstract：:Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...

journal_title：Immunology letters

authors： Van Houdt K,Nicasi I,Van Mechelen E,Veulemans B,De Ley M

更新日期：1992-03-01 00:00:00

abstract：:We studied isotype profiles of anti-HIV antibodies (Ab) in HIV-1-infected African patients with high viral loads and major B cell dysfunction. We focussed on IgG1, IgG3, and IgA as these classes and subclasses tend to support neutralizing functions against HIV. Total IgG1, IgG3 and IgA were detected in the plasma of b...

journal_title：Immunology letters

authors： Béniguel L,Bégaud E,Peruchon S,Cognasse F,Gabrié P,Marovich M,Lucht F,Genin C,Garraud O

更新日期：2004-04-30 00:00:00

abstract：:Cultured T lymphocytes from pig blood can be activated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Activation is additive with that induced by the mitogenic lectin phytohaemagglutinin (PHA). Activation by TPA differs from that induced by PHA or other mitogenic lectins in that it is not inhibited e...

journal_title：Immunology letters

authors： Kay JE,Meehan RT,Benzie CR

更新日期：1983-01-01 00:00:00

abstract：:The photobleaching energy transfer (pbFRET) technique is a fluorescence method to measure proximity relationships between molecules, especially cell surface proteins, labeled with fluorophore-conjugated monoclonal antibodies, on a pixel-by-pixel base using digital imaging microscopy. This technique enables analysis of...

journal_title：Immunology letters

authors： Bacsó Z,Bene L,Bodnár A,Matkó J,Damjanovich S

更新日期：1996-12-01 00:00:00

abstract：:Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...

journal_title：Immunology letters

authors： Ribatti D

更新日期：2017-10-01 00:00:00

abstract：:The previously called "hemoglobinase" Sm32 molecule of the adult worm of Schistosoma mansoni was chemically synthesized in 22 polymeric peptides based on the t-boc strategy. Their immunogenicity was evaluated in rabbits to which a mixture of five to six peptides of 20 amino acids long were given in three doses with Fr...

journal_title：Immunology letters

authors： Noya O,Alarcón de Noya B,Guzmán F,Bermúdez H

更新日期：2003-09-08 00:00:00

abstract：:To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...

journal_title：Immunology letters

authors： Schlegel RA,Stevens M,Lumley-Sapanski K,Williamson P

更新日期：1993-06-01 00:00:00

abstract：:Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

journal_title：Immunology letters

authors： Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

更新日期：2015-03-01 00:00:00

abstract：:Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...

journal_title：Immunology letters

authors： Bahrambeigi S,Molaparast M,Sohrabi F,Seifi L,Faraji A,Fani S,Shafiei-Irannejad V

更新日期：2020-04-01 00:00:00

abstract：:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

journal_title：Immunology letters

authors： Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

更新日期：1987-04-01 00:00:00

abstract：:An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...

journal_title：Immunology letters

authors： Naiki M,Imai Y,Kamita Y,Osawa T

更新日期：1988-08-01 00:00:00

abstract：:Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation. Inducive effect of ultraviolet (UV) has been indicated because of the enhanced expression of ADF/TRX in epidermal cells of...

journal_title：Immunology letters

authors： Sachi Y,Hirota K,Masutani H,Toda K,Okamoto T,Takigawa M,Yodoi J

更新日期：1995-01-01 00:00:00

abstract：:The prevalence of asthma and allergic disease has increased in many countries and there has been speculation that immunization promotes allergic sensitization. Bordetella pertussis infection exacerbates allergic asthmatic responses. We investigated whether whole-cell pertussis vaccine (Pw) enhanced or prevented B. per...

journal_title：Immunology letters

authors： Ennis DP,Cassidy JP,Mahon BP

更新日期：2005-02-15 00:00:00