Immune reactivity during COVID-19: Implications for treatment.

abstract：:Several immunological functions of B and T cells including IL-2 receptor expression on T cells were measured in 12-month-old Fisher-344 male rats maintained from 6 weeks of age on an ad libitum (AL) or a 40% food-restricted (FR) diet. Direct anti-SRBC plaque-forming cell (PFC) assays revealed a higher response in FR r...

journal_title：Immunology letters

authors： Iwai H,Fernandes G

更新日期：1989-12-01 00:00:00

abstract：:Several immunodominant B-cell epitopes of the P. falciparum antigen blood stage Pf155/RESA, a major vaccine candidate antigen, are located in the molecular regions containing amino acid repeats. We started to map Pf155/RESA for T cell reactive epitopes. For this purpose, short synthetic peptides corresponding to the 3...

journal_title：Immunology letters

authors： Troye-Blomberg M,Kabilan L,Riley EM,Ortlund J,Andersson G,Perlmann H,Olerup O,Högh B,Petersen E,Snow RW

更新日期：1988-11-01 00:00:00

abstract：:A375 human melanoma cell cultures grown in the presence of TGF beta contained greatly reduced cell numbers and exhibited drastic alterations in cell morphology compared to the control cultures. Preincubation of the cells with the cytokine for only 18 h was sufficient to induce these changes irreversibly. Examination o...

journal_title：Immunology letters

authors： Larisch-Bloch S,Yarom R,Sulitzeanu D

更新日期：1992-07-01 00:00:00

abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...

journal_title：Immunology letters

authors： Dubs MC,Altschuh D,Van Regenmortel MH

更新日期：1992-01-01 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...

journal_title：Immunology letters

authors： Wrotek S,Jędrzejewski T,Piotrowski J,Kozak W

更新日期：2016-09-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...

journal_title：Immunology letters

authors： Guo T,Zhao L,Zhang Y,Liu G,Yao Y,Li H

更新日期：2016-12-01 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

journal_title：Immunology letters

authors： Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

更新日期：2005-11-15 00:00:00

abstract：:We have described a monoclonal antibody with specificity for permeability-altered drug-resistant cells. This gamma G2b antibody was characterized by antibody-mediated complement-dependent cytotoxicity and by immunofluorescence analysis using a flow cytometer-cell sorter. Further experiments with the flow cytometer sho...

journal_title：Immunology letters

authors： O'Hara CJ,Price GB

更新日期：1982-07-01 00:00:00

abstract：:Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...

journal_title：Immunology letters

authors： Gougeon ML,Lecoeur H,Sasaki Y

更新日期：1999-03-01 00:00:00

abstract：:Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...

journal_title：Immunology letters

authors： Gao P,Mu M,Chen Y,He J,Tao X,Song C

更新日期：2020-09-01 00:00:00

abstract：:In human tumors of neuroectodermal origin cell surface expression of individual gangliosides is either increased or decreased relative to comparable normal cells. We have previously shown that gangliosides shed from melanoma cells can immunomodulate T cell activity. Monocytes/macrophages (m/m) are known to play an imp...

journal_title：Immunology letters

authors： Hoon DS,Jung T,Naungayan J,Cochran AJ,Morton DL,McBride WH

更新日期：1989-03-01 00:00:00

abstract：:Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephe...

journal_title：Immunology letters

authors： Pace M,D'Ovidio MC,Iale E,Strom R,Turillazzi P

更新日期：1996-05-01 00:00:00

abstract：:Pentoxifylline (PTX), a methylxanthine derivative and phosphodiesterase inhibitor, is known to influence production and/or function of some cytokines. We examined the effect of PTX on the in vitro expression of cytokine genes using endotoxin- or phytohaemagglutinin (PHA)-stimulated human blood mononuclear cells. The e...

journal_title：Immunology letters

authors： Rieneck K,Diamant M,Haahr PM,Schönharting M,Bendtzen K

更新日期：1993-08-01 00:00:00

abstract：:Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...

journal_title：Immunology letters

authors： Tsigou E,Aloizos S,Myrianthefs P,Gourgiotis S,Tsakris A,Baltopoulos G

更新日期：2014-05-01 00:00:00

abstract：:Between the ages of 2 to approximately 11 days mice respond to a challenge with syngeneic IgE by producing anti-IgE antibodies; by the age of 2 weeks they are unresponsive. Even adult mice, however, produce high titers of anti-IgE antibodies when immunized with a conjugate of syngeneic IgE and a foreign antigen such a...

journal_title：Immunology letters

authors： Haba S,Nisonoff A

更新日期：1995-09-01 00:00:00

abstract：:The immunosuppressant rapamycin is known to be a potent inhibitor of cytokine driven proliferation of T-lymphocytes and other cell types. Here we have examined the effect of rapamycin on the myeloblastic cell line M1 which responds to interleukin-6 (IL-6) with growth arrest and monocytoid differentiation. Single-agent...

journal_title：Immunology letters

authors： Kloke O,Kummer G,Seeber S

更新日期：1997-11-01 00:00:00

abstract：:The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...

journal_title：Immunology letters

authors： Choremi-Papadopoulou E,Faure GC,Malenica B,Misbah SA,Zlabinger GJ

更新日期：2009-06-30 00:00:00

abstract：:Mice lacking suppressor of cytokine signaling 1 (SOCS1) accumulate CD8(+) T lymphocytes in the thymus and in the periphery. Whereas IL-7 and IL-15 promote the generation of CD8 single positive (SP) thymocytes, IL-15 drives the expansion of CD8 T cells in the periphery. Here, we investigated whether increased productio...

journal_title：Immunology letters

authors： Ilangumaran S,Gagnon J,Leblanc C,Poussier P,Ramanathan S

更新日期：2010-08-16 00:00:00

abstract：:The effect of oligosaccharides and C-terminal lysine residues on the thermal stability of a recombinant IgG(1) monoclonal antibody was investigated using differential scanning calorimetry (DSC). The C-terminal lysine did not appear to affect the thermal stability of this IgG(1) molecule. However, oligosaccharides, whi...

journal_title：Immunology letters

authors： Liu H,Bulseco GG,Sun J

更新日期：2006-08-15 00:00:00

abstract：:Six murine monoclonal antibodies, AT-1, 2, 3, 4, 5, and 6 were produced against human recombinant tumor necrosis factor (gamma TNF). AT-1, -2, -3, -4, and -6 were IgG1, and AT-5 was IgG2a. AT-1, -2, and -3 neutralized the activity of gamma TNF (2 X 10(3) U/ml) over a range of dilutions between 5 and 500 micrograms/ml ...

journal_title：Immunology letters

authors： Shimamoto Y,Chen RL,Bollon A,Chang A,Khan A

更新日期：1988-04-01 00:00:00

abstract：:A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...

journal_title：Immunology letters

authors： Buseyne F,Stevanovic S,Rammensee HG,Rivière Y

更新日期：1997-03-01 00:00:00

abstract：:Natural anti-cholesterol antibodies (ACHAs) exist in mammalian species, moreover their level sensitively changes in pathological situations, such as atherosclerosis or HIV infection. The conditions of their production and functional role, however, still remained ill defined. Recently we developed IgG3 type monoclonal ...

journal_title：Immunology letters

authors： Izsepi E,Balogh A,Farkas A,Molnar A,Solymos E,Toth EA,Csepanyi-Komi R,Matko J

更新日期：2012-03-30 00:00:00

abstract：:B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...

journal_title：Immunology letters

authors： Matesanz-Isabel J,Sintes J,Llinàs L,de Salort J,Lázaro A,Engel P

更新日期：2011-01-30 00:00:00

abstract：:African swine fever (ASF) virus has been reported to infect cells of the monocyte family, probably macrophage-like cells, but there is variation in the apparent susceptibility of these cells. We have demonstrated that the phenotype and activity of porcine monocytic cells varies between different isolations and also up...

journal_title：Immunology letters

authors： McCullough KC,Schaffner R,Fraefel W,Kihm U

更新日期：1993-07-01 00:00:00

abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...

journal_title：Immunology letters

authors： Santoni A,Arcuri E

更新日期：2020-10-01 00:00:00

abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

journal_title：Immunology letters

authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

更新日期：2013-05-01 00:00:00

abstract：:Abnormal activation of the transcriptional factor STAT3 (signal transducer and activator of transcription 3) was recently associated with Alzheimer Disease (AD). STAT3 phosphorylation is critical for cytokine secretion linked to neuroinflammation. Moreover, STAT3 may act as a transcriptional regulator of BACE1 (β-APP ...

journal_title：Immunology letters

authors： Millot P,San C,Bennana E,Porte B,Vignal N,Hugon J,Paquet C,Hosten B,Mouton-Liger F

更新日期：2020-12-01 00:00:00

abstract：:Proliferation of mouse lymph node lymphocytes in response to concanavalin A in serum-free medium is normally dependent upon the presence of transferrin. In the absence of transferrin, little proliferation occurred, but the response was restored by addition of the iron complex of pyridoxal isonicotinoyl hydrazone (FePI...

journal_title：Immunology letters

authors： Brock JH,Stevenson J

更新日期：1987-05-01 00:00:00

abstract：:While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...

journal_title：Immunology letters

authors： Ohno H,Ogawa M,Nishikawa S,Hayashi S,Kunisada T,Nishikawa S

更新日期：1993-02-01 00:00:00

abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...

journal_title：Immunology letters

authors： Fallah-Mehrjardi K,Mirzaei HR,Masoumi E,Jafarzadeh L,Rostamian H,Khakpoor-Koosheh M,Alishah K,Noorbakhsh F,Hadjati J

更新日期：2020-07-01 00:00:00