Abstract:
:Several immunological functions of B and T cells including IL-2 receptor expression on T cells were measured in 12-month-old Fisher-344 male rats maintained from 6 weeks of age on an ad libitum (AL) or a 40% food-restricted (FR) diet. Direct anti-SRBC plaque-forming cell (PFC) assays revealed a higher response in FR rats than in AL rats when splenocytes were cultured with or without recombinant interleukin-2 (rIL-2). B cell functions were studied by using nylon wool-purified splenic B cells stimulated either with rIL-2, lipopolysaccharide (LPS), or Salmonella typhimurium mitogen (STM) as a thymus-independent antigen. Reserve plaque assay showed no difference between FR and AL rats in the secretion of anti-IgM and anti-IgG antibodies. In addition, no difference was found in proliferation of B cells stimulated by LPS, STM mitogens or rIL-2. Although purified splenic T cells demonstrated an equally proliferative response in FR and AL rats when cultured with concanavalin A (Con A) or phytohemagglutinin (PHA), T cells in FR rats developed higher responses when stimulated with an alloantigen and rIL-2. Time-course studies carried out to measure high-affinity (HA) IL-2 receptor (R) molecules by using purified T cells with rIL-2 and 125I-labeled IL-2 revealed a higher expression of IL-2R molecules on T cells of FR rats than on T cells of AL rats at 72 h after culturing with Con A.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Iwai H,Fernandes Gdoi
10.1016/0165-2478(89)90124-7subject
Has Abstractpub_date
1989-12-01 00:00:00pages
125-32issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(89)90124-7journal_volume
23pub_type
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
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pub_type: 历史文章,杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.11.004
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journal_title:Immunology letters
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doi:10.1016/0165-2478(84)90056-7
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doi:10.1016/0165-2478(89)90134-x
更新日期:1989-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0165-2478(94)90219-4
更新日期:1994-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.07.010
更新日期:2006-11-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2007.12.008
更新日期:2008-03-15 00:00:00
abstract::Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...
journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.10.011
更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.imlet.2018.10.011
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-31 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90184-r
更新日期:1990-10-01 00:00:00
abstract::The effects of interferon-alpha (IFN-alpha), INF-gamma, transforming growth factor beta (TGF-beta) and dexamethasone on low-affinity Fc receptors for IgE (Fc epsilon R2/CD23) expression on a human eosinophilic leukemia cell line, Eol-3, were examined. Fc epsilon R2/CD23 expression was enhanced by both IFN-alpha and IF...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90201-z
更新日期:1990-09-01 00:00:00