当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > Monoclonal antibodies against human recombinant tumor necrosis factor: prevention of endotoxic shock.

Monoclonal antibodies against human recombinant tumor necrosis factor: prevention of endotoxic shock.

Abstract：

:Six murine monoclonal antibodies, AT-1, 2, 3, 4, 5, and 6 were produced against human recombinant tumor necrosis factor (gamma TNF). AT-1, -2, -3, -4, and -6 were IgG1, and AT-5 was IgG2a. AT-1, -2, and -3 neutralized the activity of gamma TNF (2 X 10(3) U/ml) over a range of dilutions between 5 and 500 micrograms/ml of IgG, while AT-4, -5 and -6 failed to neutralize the activity in these concentrations. All the antibodies showed immunoprecipitating activity for gamma TNF (2 X 10(3) U/ml) over a range of dilutions between 0.5 and 500 micrograms/ml. The AT-6 was weaker than the rest. AT-1, which neutralized gamma TNF activity efficiently, and AT-4, which did not neutralize the activity, were used to protect mice against endotoxic shock. AT-1 protected mice from the lethal effects of endotoxin, while AT-4 failed to do so. AT-1, -2, and -3 also neutralized the activity of human and mouse natural TNF. AT-1, -2, and -3 neutralized the activity of gamma TNF, but not that of lymphotoxin (LT) and interferon (IFN).

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Shimamoto Y,Chen RL,Bollon A,Chang A,Khan A

doi

10.1016/0165-2478(88)90003-x

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

311-7

issue

4

eissn

0165-2478

issn

1879-0542

pii

0165-2478(88)90003-X

journal_volume

17

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • Regulation of IL-18 expression by CRH in mouse microglial cells.

    abstract：:Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2004.12.003

    authors： Yang Y,Hahm E,Kim Y,Kang J,Lee W,Han I,Myung P,Kang H,Park H,Cho D

    更新日期：2005-05-15 00:00:00

  • Suppression of Con A-induced hepatitis induction in ICOS-deficient mice.

    abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2009.11.002

    authors： Watanabe S,Ohnuki K,Hara Y,Ishida Y,Ikarashi Y,Ogawa S,Kishimoto H,Tanabe K,Abe R

    更新日期：2010-01-18 00:00:00

  • Identification of a novel single chain fragment variable antibody targeting CD24-expressing cancer cells.

    abstract：:CD24 is a heavy glycosylated protein that is overexpressed in numerous cancer and cancer stem cells. It is involved in the development, invasion, and metastasis of the cancer cells. CD24 can be considered in targeted cancer therapy as a new target. Here, phage display technology was used for the identification of nove...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2017.08.028

    authors： Eyvazi S,Kazemi B,Bandehpour M,Dastmalchi S

    更新日期：2017-10-01 00:00:00

  • Dual effect of lectins on macrophages: potentiation of bacterial uptake and suppression of bactericidal activity.

    abstract：:Pretreatment of murine bone marrow-derived macrophages with wheat germ agglutinin (WGA) and concanavalin A (Con A) markedly enhanced the uptake of Staphylococcus aureus H and Escherichia coli 08, respectively. Pretreatment of the respective bacteria with these lectins also greatly increased their uptake by the macroph...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90048-9

    authors： Gallily R,Stain I,Zaady O

    更新日期：1986-09-01 00:00:00

  • Intravascular pathobiology of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF). I. Intravenous infusion in guinea pigs.

    abstract：:Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：

    authors： Demopoulos CA,Tsabikakis GE,Kapoulas VM

    更新日期：1981-08-01 00:00:00

  • Cytokine sensitivity of human NK cells during immunosenescence. 2. IL2-induced interferon gamma secretion.

    abstract：:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(96)02519-9

    authors： Krishnaraj R,Bhooma T

    更新日期：1996-04-01 00:00:00

  • Whole-cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma.

    abstract：:The prevalence of asthma and allergic disease has increased in many countries and there has been speculation that immunization promotes allergic sensitization. Bordetella pertussis infection exacerbates allergic asthmatic responses. We investigated whether whole-cell pertussis vaccine (Pw) enhanced or prevented B. per...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2004.10.011

    authors： Ennis DP,Cassidy JP,Mahon BP

    更新日期：2005-02-15 00:00:00

  • Human T cell subsets differ in their ability to migrate in vitro and to produce T cell migration inhibitory factor.

    abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90122-7

    authors： Kowalczyk D,Pryjma J,Zembala M

    更新日期：1986-08-01 00:00:00

  • MHC class II/T-cell receptor interactions potentiate secretion of IgG but not IgM in response to T-dependent antigens.

    abstract：:We have examined whether the interaction of peptide-loaded MHC molecules on the surface of B-cells with antigen-specific T-cell receptors (TCRs) enhances Ig secretion in the presence of other antigen-independent interactions in vitro. B-cells specific for region 25-40 of beta-lactoglobulin (beta-LG) were stimulated in...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00002-9

    authors： Takahashi Y,Ametani A,Totsuka M,Fujine K,Tsuji NM,Kurisaki J,Kaminogawa S

    更新日期：1998-04-01 00:00:00

  • Enhanced expression of B7.2 (CD86) by percutaneous sensitization with house dust mite antigen.

    abstract：:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(02)00196-7

    authors： Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

    更新日期：2003-01-02 00:00:00

  • Eosinophil-mediated cellular cytotoxicity induced by zymosan-activated serum.

    abstract：:The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90078-7

    authors： De Simone C,Ferrari M,Pugnaloni L,Ferrarelli G,Rumi C,Sorice F

    更新日期：1986-01-01 00:00:00

  • Cytokine-induced tumor immunogenicity: endogenous interleukin-1 alpha expressed by fibrosarcoma cells confers reduced tumorigenicity.

    abstract：:A direct correlation between the constitutive expression of IL-1 alpha and reduced tumorigenicity of fibrosarcomas was observed. This was established in fibrosarcoma cell lines which produce IL-1 alpha 'spontaneously', possibly as an aberration of oncogene-mediated transformation or upon IL-1 alpha gene transfer. In f...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/0165-2478(93)90163-v

    authors： Apte RN,Douvdevani A,Zoller M,White RM,Dvorkin T,Shimoni N,Fima E,Hacham M,Huleihel M,Benharroch D

    更新日期：1993-12-01 00:00:00

  • Reduced cytokine-mediated up-regulation of HLA-DR in TAP-deficient fibroblasts.

    abstract：:Human deficiency in transporter associated with antigen processing (TAP) is characterized by a very low surface expression of human leukocyte antigen (HLA) class I molecules in hematopoietic and non hematopoietic cells. Among the latter, TAP-deficient skin fibroblasts have previously been shown by us to be very sensit...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2006.07.010

    authors： Zimmer J,Poli A,Andrès E,Hanau D,Brons NH,Hentges F

    更新日期：2006-11-15 00:00:00

  • Synthetic peptide with antiproliferative activity: a short C-terminal fragment of the human interferon alpha-2 molecule.

    abstract：:The biological activity of six synthetic peptides of the 124-144 region of the human interferon alpha-2 (IFN alpha-2) molecule was studied. Peptides were examined for their ability to inhibit mitogen induced proliferation of human blood cells in vitro. Only the peptide corresponding to the amino acid sequence 124-138 ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(92)90004-8

    authors： Danilkovich AV,Freze KV,Shevalier AF,Samukov VV,Kirkin AF,Gusev MV

    更新日期：1992-01-01 00:00:00

  • Early induction of anti-double-stranded DNA antibodies in lupus-prone MRL mice inoculated with Ly-24+ cells cloned from lymph node cells of an MRL/Mp-lpr/lpr mouse: possible effect of putative cytokines produced by cloned Ly-24+ cells.

    abstract：:We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(90)90035-o

    authors： Kanai Y,Isonishi S,Katagiri T,Koizumi T,Miura K,Kurosawa Y

    更新日期：1990-03-01 00:00:00

  • Effects of antinuclear autoantibodies on RNA polymerase.

    abstract：:DNA-dependent RNA polymerase was partially purified from wheat germ extract and tested for inhibition by antinuclear autoantibodies from the sera of patients with connective tissue diseases. The enzyme was inhibited by anti-DNA and by autoantibodies to the nuclear ribonucleoprotein nRNP. Autoantibodies to other ribonu...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(83)90093-7

    authors： Hough DW,Miller NI,Maddison PJ

    更新日期：1983-03-01 00:00:00

  • 2-Mercapto-ethanol enhancement of agglutination reaction--a possible in vitro serological correlate for assessment of functional immunity in simian malaria.

    abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(84)90090-7

    authors： Ravindran B,Biswas S,Hussain QZ,Chaudhuri SN

    更新日期：1984-01-01 00:00:00

  • TNFalpha and anti-Fas antibodies regulate Ly-6E.1 expression by tumor cells: a possible link between angiogenesis and Ly-6E.1.

    abstract：:Angiogenic and poorly angiogenic tumor variants were obtained by an intraperitoneal inoculation of cells from clones of polyoma-virus transformed BALB/c 3T3 cells into syngeneic mice. The angiogenic tumor cells expressed a higher tumorigenicity phenotype and a higher capacity to produce artificial pulmonary metastases...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(96)02675-2

    authors： Sagi-Assif O,Traister A,Katz BZ,Anavi R,Eskenasy M,Witz IP

    更新日期：1996-12-01 00:00:00

  • Novel mechanism of signaling by CD28.

    abstract：:Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2010.01.007

    authors： Bjørgo E,Taskén K

    更新日期：2010-03-10 00:00:00

  • Immunological functions in food-restricted rats: enhanced expression of high-affinity interleukin-2 receptors on splenic T cells.

    abstract：:Several immunological functions of B and T cells including IL-2 receptor expression on T cells were measured in 12-month-old Fisher-344 male rats maintained from 6 weeks of age on an ad libitum (AL) or a 40% food-restricted (FR) diet. Direct anti-SRBC plaque-forming cell (PFC) assays revealed a higher response in FR r...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(89)90124-7

    authors： Iwai H,Fernandes G

    更新日期：1989-12-01 00:00:00

  • Subpopulations of circulating lymphocytes in adults with coeliac disease.

    abstract：:Circulating lymphocytes were enumerated in 25 patients with coeliac disease and in 24 healthy donors by immunofluorescent staining using monoclonal antibodies for T cell surface phenotypic markers T11 (mature), T4 (helper) and T8 (suppressor) or polyvalent antisera for surface immunoglobulins (B cells). Proportions of...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90119-7

    authors： Vĕtvicka V,Tlaskalová-Hogenová H,Fric P,Brochier J

    更新日期：1986-08-01 00:00:00

  • Deficient transformation of murine trisomy 16 fetal liver cells by the Abelson and J2 viruses.

    abstract：:Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(92)90092-3

    authors： Berger CN,Epstein CJ

    更新日期：1992-06-01 00:00:00

  • Integrin αvβ6 cooperates with resiquimod to restore antigen-specific immune tolerance in airway allergy.

    abstract：BACKGROUND:Integrin αvβ6 can convert the transforming growth factor (TGF)-β precursor to the mature form. Resiquimod (R848) can generate TGF-β-producing regulatory T cells (Treg). Thus, to concurrent administration of specific antigen and R848 may generate antigen-specific Tregs, that is expected to restore immune tole...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2020.12.011

    authors： Ma F,Zhang YY,Yang G,Mo LH,Liu DB,Yang LT,Liu ZG,Ning Y,Yang PC

    更新日期：2021-02-01 00:00:00

  • Effect of an autoreactive T cell clone from (NZB x NZW)F1 mice on the production of anti-DNA antibodies in vivo and in vitro.

    abstract：:An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(88)90175-7

    authors： Naiki M,Imai Y,Kamita Y,Osawa T

    更新日期：1988-08-01 00:00:00

  • Synergistic effect of prolactin on IFN-gamma-mediated growth arrest in human monoblastic cells: correlation with the up-regulation of IFN-gamma receptor gene expression.

    abstract：:Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in mono...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(96)02622-3

    authors： Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

    更新日期：1996-11-01 00:00:00

  • Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes.

    abstract：:Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2006.12.009

    authors： Moriyama H,Yonehara S

    更新日期：2007-03-15 00:00:00

  • Distinct cell death markers identified in critical care patient survivors diagnosed with sepsis.

    abstract：:Sepsis is an abnormal immune response to infection characterized by an overwhelming systemic inflammation and cell death. Non-apoptotic cell death pertaining to pyroptosis, necroptosis and autophagy contribute to sepsis pathogenesis apart from classical apoptotic cell death. The objective of the current study is to in...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2020.12.009

    authors： Mallarpu CS,Ponnana M,Prasad S,Singarapu M,Kim J,Haririparsa N,Bratic N,Brar H,Chelluri LK,Madiraju C

    更新日期：2021-01-03 00:00:00

  • Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration.

    abstract：:In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.08.005

    authors： Yoshida T,Suzuki S,Iwasaki Y,Kaneko A,Saito A,Enomoto Y,Higashino A,Watanabe A,Suzuki J,Inoue K,Kuroda T,Takada M,Ito R,Ito M,Akari H

    更新日期：2013-07-01 00:00:00

  • FT-2 antigen for distinguishing lymphocyte subpopulations in the developing thymus.

    abstract：:The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90004-5

    authors： Takashi T,Kasai M,Tanaka N,Takahashi T,Tokunaga T

    更新日期：1985-01-01 00:00:00

  • TLR5 ligation by flagellin converts tolerogenic dendritic cells into activating antigen-presenting cells that preferentially induce T-helper 1 responses.

    abstract：:Dendritic cells (DCs) differentiated in the presence of IL-10 preferentially induce regulatory T-cells and tolerance. Whether the tolerogenic properties displayed by these DCs (Tol-DCs) can be overcome has not been fully explored. Here we show for the first time that Tol-DCs express higher levels of TLR5 mRNA, but not...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2009.06.007

    authors： Vicente-Suarez I,Brayer J,Villagra A,Cheng F,Sotomayor EM

    更新日期：2009-08-15 00:00:00