Intravascular pathobiology of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF). I. Intravenous infusion in guinea pigs.

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein expressed by rat mast cells and basophils. MAFA clustering by its specific monoclonal antibody, (mAb) G63, efficiently inhibits the FcvarepsilonRI induced secretory response of mucosal-type mast cells of the RBL-2H3 line, as well as b...

journal_title：Immunology letters

authors： Abramson J,Pecht I

更新日期：2002-06-03 00:00:00

abstract：:Good Syndrome is a rare clinical entity first described as the conjunction of thymoma and hypogammaglobulinemia, and more recently depicted as a complex disease integrating a medical history of thymoma with humoral immunodeficiency (more accurately stated: hypogammaglobulinemia) with or without cellular immunodeficien...

journal_title：Immunology letters

authors： Guevara-Hoyer K,Fuentes-Antrás J,Calatayud Gastardi J,Sánchez-Ramón S

更新日期：2021-01-05 00:00:00

abstract：:E1, E3-deleted, replication-deficient recombinant adenoviruses are widely studied as vectors for their capacity to transfer therapeutic genes in vivo. They can infect a wide variety of dividing and quiescent cells from different organs and possess a large packaging capacity. One of the major limitations in the use of ...

journal_title：Immunology letters

authors： Christ M,Lusky M,Stoeckel F,Dreyer D,Dieterlé A,Michou AI,Pavirani A,Mehtali M

更新日期：1997-06-01 00:00:00

abstract：:After exposure to a concanavalin A (Con A)-unreactive variant of alpha 1-acid glycoprotein (AGP), macrophages released an inhibitor of interleukin-1 (IL-1) proliferative activity in the thymocyte comitogenic assay. This effect was observed with AGP concentrations above 100 micrograms/ml in the macrophage supernatant a...

journal_title：Immunology letters

authors： Bories PN,Kodari E,Feger J,Rouzeau JD,Agneray J,Durand G

更新日期：1990-10-01 00:00:00

abstract：:Crosslinking of the B-cell receptor (BCR) for antigen to low-affinity receptors for IgG (Fc gamma RII) inhibits B-cell activation induced by BCR aggregation. The cell-triggering properties of the BCR depend on tyrosine-containing activation motifs (TAM), in the intracytoplasmic domain of its Ig alpha and Ig beta subun...

journal_title：Immunology letters

authors： Daëron M,Malbec O,Latour S,Espinosa E,Pina P,Fridman WH

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...

journal_title：Immunology letters

authors： Sikora J,Smycz-Kubańska M,Mielczarek-Palacz A,Bednarek I,Kondera-Anasz Z

更新日期：2018-09-01 00:00:00

abstract：:Screening of expression cDNA libraries derived from human neoplasms with autologous sera (SEREX) is an established method for defining antigens immunogenic in individual cancer patients. Although the majority of SEREX-derived cDNA clones encode autoantigens, some of them represent shared cancer antigens with cancer-re...

journal_title：Immunology letters

authors： Lagarkova MA,Koroleva EP,Kuprash DV,Boitchenko VE,Kashkarova UA,Nedospasov SA,Shebzukhov YV

更新日期：2003-01-02 00:00:00

abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...

journal_title：Immunology letters

authors： Haskó G,Elenkov IJ,Vizi ES

更新日期：1995-07-01 00:00:00

abstract：:The possibility of inducing immune responses to murine interleukin-4 (IL-4) and IL-13 and generating anti-cytokine monoclonal antibodies (mAbs) was studied in IL-4- and IL-13-knockout mice. The minimal doses of IL-4 or IL-13 that could induce significant anti-cytokine responses with titers of 5000-10,000 were 20 micro...

journal_title：Immunology letters

authors： Shichkin VP,Spivak NY

更新日期：2006-02-15 00:00:00

abstract：:Many details in the expression pattern of Epstein-Barr virus (EBV)-encoded proteins, their role in blast and growth transformation in infected B lymphocytes are known, but 'black holes' still exist. The two main types of virus-B lymphocyte interactions are denoted as Type I and Type III. These are characterized by the...

journal_title：Immunology letters

authors： Klein E,Teramoto N,Gogolák P,Nagy N,Björkholm M

更新日期：1999-05-03 00:00:00

abstract：:When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...

journal_title：Immunology letters

authors： Malbec O,Daëron M

更新日期：2012-03-30 00:00:00

abstract：:CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...

journal_title：Immunology letters

authors： Bretz NP,Salnikov AV,Doberstein K,Garbi N,Kloess V,Joumaa S,Naumov I,Boon L,Moldenhauer G,Arber N,Altevogt P

更新日期：2014-09-01 00:00:00

abstract：:The monoclonal antibody (mAb) AHT-107 recognized a determinant distal to the interleukin 2 (IL-2) binding site on the p55 subunit of the IL-2 receptor (IL-2R) (the Tac antigen, CD25) of human T lymphoblasts, while the mAb AHT-54 recognized a determinant close to the IL-2 binding site as did the anti-Tac. The AHT-107 i...

journal_title：Immunology letters

authors： Osawa H,Diamantstein T

更新日期：1989-02-01 00:00:00

abstract：:While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...

journal_title：Immunology letters

authors： Ohno H,Ogawa M,Nishikawa S,Hayashi S,Kunisada T,Nishikawa S

更新日期：1993-02-01 00:00:00

abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...

journal_title：Immunology letters

authors： Sármay G,Koncz G,Gergely J

更新日期：1996-12-01 00:00:00

abstract：:The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly wi...

journal_title：Immunology letters

authors： Kolb H,Ben-Nun A,Cohen IR,Barberena I,Kiesel U

更新日期：1985-01-01 00:00:00

abstract：:In this study, we tried to establish a relationship between the immunopotentiating effects and the antioxidant activity of the immunostimulating compound, diethyldithiocarbamate (DDC). We studied the effects of DDC treatment on enriched T and B murine spleen lymphocytes in an in vivo-ex vivo model of O2-induced immune...

journal_title：Immunology letters

authors： Lacombe P,Carre I,Fay M,Pocidalo JJ

更新日期：1988-06-01 00:00:00

abstract：:Pretreatment with interleukin (IL)-10 inhibited the release of growth-related oncogene GRO-alpha but not of epithelial-cell derived neutrophil activating protein (ENA)-78, after injection of lipopolysaccharide (LPS) into healthy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha ...

journal_title：Immunology letters

authors： Olszyna DP,Pajkrt D,van Deventer SJ,van der Poll T

更新日期：2001-08-01 00:00:00

abstract：:The role of the immunomodulator Protein A (PA) (from Staphylococcus aureus, Cowan I strain) in the control of leishmanial infection was studied in experimental animals. Treatment of Leishmania donovani infected hamsters with PA led to a moderate level of reduction of parasite load in their spleen (68%) and liver (46%)...

journal_title：Immunology letters

authors： Ghose AC,Mookerjee A,Sengupta K,Ghosh AK,Dasgupta S,Ray PK

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Previous studies have reported an association between polymorphisms in Il17A and IL17F genes and the prevalence of rheumatoid arthritis (RA) in Caucasian populations. The aim of the current study was to investigate that polymorphisms in both genes may affect RA susceptibility in the Tunisian population and t...

journal_title：Immunology letters

authors： Marwa OS,Kalthoum T,Wajih K,Kamel H

更新日期：2017-03-01 00:00:00

abstract：:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...

journal_title：Immunology letters

authors： Krishnaraj R,Bhooma T

更新日期：1996-04-01 00:00:00

abstract：:Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...

journal_title：Immunology letters

authors： Coll JM

更新日期：1988-05-01 00:00:00

abstract：:Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...

journal_title：Immunology letters

authors： Reiling N,Ehlers S,Hölscher C

更新日期：2008-02-15 00:00:00

abstract：:Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...

journal_title：Immunology letters

authors： Cho ML,Jung YO,Moon YM,Min SY,Yoon CH,Lee SH,Park SH,Cho CS,Jue DM,Kim HY

更新日期：2006-03-15 00:00:00

abstract：:Mechanistic target for rapamycin (mTOR) is a serine/threonine protein kinase that forms two distinct complexes mTORC1 and mTORC2, integrating mitogen and nutrient signals to regulate cell survival and proliferation; processes which are commonly deregulated in human cancers. mTORC1 and mTORC2 have divergent molecular a...

journal_title：Immunology letters

authors： Holroyd AK,Michie AM

更新日期：2018-04-01 00:00:00

abstract：:Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...

journal_title：Immunology letters

authors： Taljanidisz J,Spasokukotskaja T,Sasvári-Székely M,Antoni F,Staub M

更新日期：1987-06-01 00:00:00

abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...

journal_title：Immunology letters

authors： Fallah-Mehrjardi K,Mirzaei HR,Masoumi E,Jafarzadeh L,Rostamian H,Khakpoor-Koosheh M,Alishah K,Noorbakhsh F,Hadjati J

更新日期：2020-07-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...

journal_title：Immunology letters

authors： Ben-Haj-Ayed A,Moussa A,Ghedira R,Gabbouj S,Miled S,Bouzid N,Tebra-Mrad S,Bouaouina N,Chouchane L,Zakhama A,Hassen E

更新日期：2016-01-01 00:00:00

abstract：:Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1987-01-01 00:00:00

abstract：:Murine peritoneal macrophages were isolated by adherence and their listericidal activity assessed in the presence or absence of selected cytokines. Untreated macrophages were not highly listericidal, showing moderate killing in the first 2 h after infection, and allowed progressive microbial growth thereafter (up to 9...

journal_title：Immunology letters

authors： Denis M,Gregg EO

更新日期：1991-03-01 00:00:00