MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

abstract：:Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...

journal_title：Immunology letters

authors： Pages F,Berger A,Lebel-Binay S,Zinzindohoue F,Danel C,Piqueras B,Carriere O,Thiounn N,Cugnenc PH,Fridman WH

更新日期：2000-12-01 00:00:00

abstract：:The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...

journal_title：Immunology letters

authors： Choremi-Papadopoulou E,Faure GC,Malenica B,Misbah SA,Zlabinger GJ

更新日期：2009-06-30 00:00:00

abstract：:Establishment and maintenance of pregnancy represents a challenge for the maternal immune system since it has to defend against pathogens and tolerate paternal alloantigens expressed in fetal tissues. Regulatory T (Treg) cells, a subset of suppressor CD4(+) T cells, play a dominant role in the maintenance of immunolog...

journal_title：Immunology letters

authors： La Rocca C,Carbone F,Longobardi S,Matarese G

更新日期：2014-11-01 00:00:00

abstract：:Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing...

journal_title：Immunology letters

authors： Buchsbaum RJ,Fabry JA,Lieberman J

更新日期：1996-09-01 00:00:00

abstract：:Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mR...

journal_title：Immunology letters

authors： Kim JO,Cha HR,Kim ED,Kweon MN

更新日期：2012-09-01 00:00:00

abstract：:Several immunodominant B-cell epitopes of the P. falciparum antigen blood stage Pf155/RESA, a major vaccine candidate antigen, are located in the molecular regions containing amino acid repeats. We started to map Pf155/RESA for T cell reactive epitopes. For this purpose, short synthetic peptides corresponding to the 3...

journal_title：Immunology letters

authors： Troye-Blomberg M,Kabilan L,Riley EM,Ortlund J,Andersson G,Perlmann H,Olerup O,Högh B,Petersen E,Snow RW

更新日期：1988-11-01 00:00:00

abstract：:The effect of oligosaccharides and C-terminal lysine residues on the thermal stability of a recombinant IgG(1) monoclonal antibody was investigated using differential scanning calorimetry (DSC). The C-terminal lysine did not appear to affect the thermal stability of this IgG(1) molecule. However, oligosaccharides, whi...

journal_title：Immunology letters

authors： Liu H,Bulseco GG,Sun J

更新日期：2006-08-15 00:00:00

abstract：:A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...

journal_title：Immunology letters

authors： Scarlatti G,Leitner T,Hodara V,Jansson M,Karlsson A,Wahlberg J,Rossi P,Uhlén M,Fenyö EM,Albert J

更新日期：1996-06-01 00:00:00

abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

journal_title：Immunology letters

authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

更新日期：2013-05-01 00:00:00

abstract：:Seroma is a frequent complication of breast cancer surgery, the etiology of which remains indefinite. It represents a subcutaneous accumulation of fluid frequently reported after surgical procedures such as axillary lymph node dissection. Despite previous studies have associated seroma fluid to an inflammatory exudate...

journal_title：Immunology letters

authors： Montalto E,Mangraviti S,Costa G,Carrega P,Morandi B,Pezzino G,Bonaccorsi I,Cancellieri A,Mingari MC,Mesiti M,Ferlazzo G,Melioli G

更新日期：2010-06-15 00:00:00

abstract：:CD24 is a heavy glycosylated protein that is overexpressed in numerous cancer and cancer stem cells. It is involved in the development, invasion, and metastasis of the cancer cells. CD24 can be considered in targeted cancer therapy as a new target. Here, phage display technology was used for the identification of nove...

journal_title：Immunology letters

authors： Eyvazi S,Kazemi B,Bandehpour M,Dastmalchi S

更新日期：2017-10-01 00:00:00

abstract：:Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a give...

journal_title：Immunology letters

authors： O'Connor JE,Herrera G,Martínez-Romero A,de Oyanguren FS,Díaz L,Gomes A,Balaguer S,Callaghan RC

更新日期：2014-11-01 00:00:00

abstract：:For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...

journal_title：Immunology letters

authors： Thomé R,Lopes SC,Costa FT,Verinaud L

更新日期：2013-06-01 00:00:00

abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...

journal_title：Immunology letters

authors： Zhao Y,Croft M

更新日期：2012-01-30 00:00:00

abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...

journal_title：Immunology letters

authors： Ma Y,Liu X,Wei Z,Wang X,Xu D,Dai S,Li Y,Gao M,Ji C,Guo C,Zhang L,Wang X

更新日期：2014-11-01 00:00:00

abstract：:Rheumatic fever (RF) and chronic rheumatic heart disease (RHD) are complications of oropharyngeal infection caused by Streptococcus pyogenes. Despite the importance of the complement system against infections and autoimmunity diseases, studies on the role of the lectin pathway in RF and RHD are scarce. Thus, our aim w...

journal_title：Immunology letters

authors： Catarino SJ,Andrade FA,Bavia L,Guilherme L,Messias-Reason IJ

更新日期：2021-01-01 00:00:00

abstract：:Normal and tumor-bearing host (TBH) peritoneal macrophage (M phi) responses to in vitro lipopolysaccharide (LPS) treatment were measured by assessing functional and phenotypic changes. Both normal and TBH untreated M phi suppressed mixed lymphocyte reaction (MLR) reactivity at all concentrations. Normal host M phi tre...

journal_title：Immunology letters

authors： Askew D,Yurochko AD,Burger CJ,Elgert KD

更新日期：1990-03-01 00:00:00

abstract：:Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...

journal_title：Immunology letters

authors： Zhang K,Sun YL,Zhou SN,Xu RN,Liu ZW,Wang FS,Shi M

更新日期：2019-09-01 00:00:00

abstract：:Sepsis is an abnormal immune response to infection characterized by an overwhelming systemic inflammation and cell death. Non-apoptotic cell death pertaining to pyroptosis, necroptosis and autophagy contribute to sepsis pathogenesis apart from classical apoptotic cell death. The objective of the current study is to in...

journal_title：Immunology letters

authors： Mallarpu CS,Ponnana M,Prasad S,Singarapu M,Kim J,Haririparsa N,Bratic N,Brar H,Chelluri LK,Madiraju C

更新日期：2021-01-03 00:00:00

abstract：:A monoclonal human rheumatoid factor (RF-AN) reactive with human Fc gamma is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having C gamma 2 or C gamma 3 domain deletions or IgG3m (5) or Ig3m (21) proteins having argi...

journal_title：Immunology letters

authors： Jefferis R,Nik Jaafar MI,Steinitz M

更新日期：1984-01-01 00:00:00

abstract：:Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-va...

journal_title：Immunology letters

authors： Staalsoe T,Jensen AT,Theander TG,Hviid L

更新日期：2002-11-01 00:00:00

abstract：:The regulatory effect of Z-100 on the balance of Th1/Th2 cell responses in BALB/c mice bearing Meth-A fibrosarcoma was investigated. In tumor bearing mice, Th1 cytokine production (IL-2, IFN-gamma) are suppressed and Th2 cytokine production (IL-4, IL-10) are increased, as compared with those of normal mice. The admini...

journal_title：Immunology letters

authors： Oka H,Emori Y,Ohya O,Kobayashi N,Sasaki H,Tanaka Y,Hayashi Y,Nomoto K

更新日期：1999-11-01 00:00:00

abstract：:CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...

journal_title：Immunology letters

authors： Bretz NP,Salnikov AV,Doberstein K,Garbi N,Kloess V,Joumaa S,Naumov I,Boon L,Moldenhauer G,Arber N,Altevogt P

更新日期：2014-09-01 00:00:00

abstract：:Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as c...

journal_title：Immunology letters

authors： Láng I,Taraba I,Petrányi G

更新日期：1981-11-01 00:00:00

abstract：:Incorporation of [3h]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentag...

journal_title：Immunology letters

authors： Raile A,Hammann KP,Scheiner O,Schulz T,Erdei A,Dierich MP

更新日期：1982-06-01 00:00:00

abstract：:Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circ...

journal_title：Immunology letters

authors： Renggli J,Valmori D,Romero JF,Eberl G,Romero P,Betschart B,Corradin G

更新日期：1995-05-01 00:00:00

abstract：:A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...

journal_title：Immunology letters

authors： Buseyne F,Stevanovic S,Rammensee HG,Rivière Y

更新日期：1997-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...

journal_title：Immunology letters

authors： Guo T,Zhao L,Zhang Y,Liu G,Yao Y,Li H

更新日期：2016-12-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...

journal_title：Immunology letters

authors： Schiött A,Sjögren HO,Lindvall M

更新日期：2000-06-01 00:00:00

abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...

journal_title：Immunology letters

authors： Inuzuka S,Koga S,Nishikido M,Miyata Y,Kanda S,Shimokawa I,Tanaka M,Saito Y,Kanetake H

更新日期：2002-09-02 00:00:00