Abstract:
:Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-variation with protection rather than on demonstration of causal relationships. We have studied the relationship between variant surface antigen-specific antibodies and clinical protection from Plasmodium falciparum malaria in general, and from pregnancy-associated malaria (PAM) in particular, to provide robust evidence of a causal link between the two in order to allow efficient and evidence-based identification of candidate antigens for malaria vaccine development.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Staalsoe T,Jensen AT,Theander TG,Hviid Ldoi
10.1016/s0165-2478(02)00159-1subject
Has Abstractpub_date
2002-11-01 00:00:00pages
133-6issue
2eissn
0165-2478issn
1879-0542pii
S0165247802001591journal_volume
84pub_type
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