Plasma levels of sTNFR p75 and IL-8 in patients with HIV-1 infection.

Abstract:

:We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may reflect the degree of activation of the TNF alpha system. We measured concentrations of sTNFR p75 and IL-8 with immunoassays in the plasma of 99 HIV-1-infected patients at different stages of disease (Centers for Disease Control classification) and in 20 healthy control subjects. Plasma levels of sTNFR p75 were elevated in most of the asymptomatic seropositive patients without CD4+ T cell depletion (Stage IIA) and in most of patients of all clinical groups compared with controls. However, in the majority of those patients plasma levels of IL-8 were not higher than those of controls. Our results suggest that sTNFR p75 levels but not IL-8 levels in circulating blood are high in the course of HIV-1 infection.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Hober D,Benyoucef S,Delannoy AS,De Groote D,Ajana F,Mouton Y,Wattré P

doi

10.1016/0165-2478(96)02583-7

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

57-60

issue

1

eissn

0165-2478

issn

1879-0542

pii

0165247896025837

journal_volume

52

pub_type

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