Abstract:
:We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may reflect the degree of activation of the TNF alpha system. We measured concentrations of sTNFR p75 and IL-8 with immunoassays in the plasma of 99 HIV-1-infected patients at different stages of disease (Centers for Disease Control classification) and in 20 healthy control subjects. Plasma levels of sTNFR p75 were elevated in most of the asymptomatic seropositive patients without CD4+ T cell depletion (Stage IIA) and in most of patients of all clinical groups compared with controls. However, in the majority of those patients plasma levels of IL-8 were not higher than those of controls. Our results suggest that sTNFR p75 levels but not IL-8 levels in circulating blood are high in the course of HIV-1 infection.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hober D,Benyoucef S,Delannoy AS,De Groote D,Ajana F,Mouton Y,Wattré Pdoi
10.1016/0165-2478(96)02583-7subject
Has Abstractpub_date
1996-08-01 00:00:00pages
57-60issue
1eissn
0165-2478issn
1879-0542pii
0165247896025837journal_volume
52pub_type
杂志文章abstract::Mice lacking suppressor of cytokine signaling 1 (SOCS1) accumulate CD8(+) T lymphocytes in the thymus and in the periphery. Whereas IL-7 and IL-15 promote the generation of CD8 single positive (SP) thymocytes, IL-15 drives the expansion of CD8 T cells in the periphery. Here, we investigated whether increased productio...
journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
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doi:10.1016/0165-2478(96)02570-9
更新日期:1996-07-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90158-7
更新日期:1991-03-01 00:00:00
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journal_title:Immunology letters
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doi:10.1016/0165-2478(87)90137-4
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00089-9
更新日期:1999-06-01 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.07.006
更新日期:2009-09-22 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1988-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1993-06-01 00:00:00
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journal_title:Immunology letters
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更新日期:1991-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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journal_title:Immunology letters
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更新日期:1995-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90183-x
更新日期:1994-05-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00153-3
更新日期:1998-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2012-01-30 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90048-3
更新日期:1985-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2008-05-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1987-12-01 00:00:00