Abstract:
:The monoclonal antibody 3A35 which binds mouse polymorphonuclear leucocytes (PMN) and monocytes was injected intravenously (i.v.) into normal mice. A great diminution of circulating PMN was observed. The percentage of PMN passed through a minimum (2.5%) 20 min after antibody injection and returned to normal value (18.3%) within 24 h. After repeated daily injections, the ability of the antibody to induce granulopenia attenuated. Moreover, mice bearing the 3A35-producing hybridoma as an ascitic tumor had a normal percentage of blood PMN and a normal granulopoiesis as judged from bone marrow cytological examination. Thus, the monoclonal antibody produced a transitory diminution of PMN but could not induce a lasting granulopenia.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Beurton D,Collet B,Martin A,Toujas L,Bourel D,Genetet Bdoi
10.1016/0165-2478(85)90048-3subject
Has Abstractpub_date
1985-01-01 00:00:00pages
43-7issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(85)90048-3journal_volume
10pub_type
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abstract::This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
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