Diminution of circulating polymorphonuclear leucocytes by administration of a monoclonal antibody reacting with granulocytes and monocytes.

abstract：:This paper describes a new murine monoclonal antibody, UN5, raised against human thymocytes. This antibody recognizes a molecule of approximately 45 kDa on thymocytes. Flow cytometric analysis reveals a high intensity of labeling with the majority of thymocytes, whereas only CD20+ cells from peripheral whole-blood sam...

journal_title：Immunology letters

authors： Tassone P,Bonelli P,Tuccillo F,Bond HM,Turco MC,Morrone G,Cecco L,Cerra M,Venuta S

更新日期：1994-02-01 00:00:00

abstract：:Tuberculosis (TB) is a highly infectious disease and its early and precise diagnosis is essential to reduce morbidity and mortality of patients. Since the routine diagnostic tests (like Monteux, AFB smear microscopy, chest X-Ray) do not give infallible results, additional tests are always recommended. Therefore to add...

journal_title：Immunology letters

authors： Tripathi DK,Srivastava K,Nagpal KL,Shukla PK,Srivastava KK

更新日期：2019-05-01 00:00:00

abstract：:We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...

journal_title：Immunology letters

authors： Zhou X,Yang N,Lu L,Ding Q,Jiao Z,Zhou Y,Chou KY

更新日期：2007-05-15 00:00:00

abstract：:The effect of melphalan (L-PAM; L-phenylalanine mustard) administration on natural killer (NK) and natural cytotoxic (NC) activities of spleen cells from normal noninoculated BALB/c mice and mice bearing large MOPC-315 plasmacytoma tumors was investigated. Injection of L-PAM (7.5 or 15.0 mg/kg) had no effect on NK and...

journal_title：Immunology letters

authors： Nahas F,Ophir R,Ben-Efraim S

更新日期：1985-01-01 00:00:00

abstract：:Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...

journal_title：Immunology letters

authors： Moriyama H,Yonehara S

更新日期：2007-03-15 00:00:00

abstract：:Graft failure (GF) following bone marrow transplantation (BMT) in man is usually attributed to allograft rejection; however, other mechanisms of GF exist. Exposure of the developing allograft to viruses, myelotoxic drugs, and damage to the host-derived marrow stroma during graft-versus-host disease (GVHD) may all caus...

journal_title：Immunology letters

authors： Hows JM

更新日期：1991-07-01 00:00:00

abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....

journal_title：Immunology letters

authors： Ryu JG,Lee J,Kim EK,Seo HB,Park JS,Lee SY,Moon YM,Yoo SH,Park YW,Park SH,Cho ML,Kim HY

更新日期：2015-02-01 00:00:00

abstract：:While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...

journal_title：Immunology letters

authors： Ohno H,Ogawa M,Nishikawa S,Hayashi S,Kunisada T,Nishikawa S

更新日期：1993-02-01 00:00:00

abstract：:Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...

journal_title：Immunology letters

authors： Hernández MX,Barçante TA,Vilela L,Tafuri WL,Afonso LC,Vieira LQ

更新日期：2006-05-15 00:00:00

abstract：:The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 μM)-dependently increased the HO-1 mRNA and protein expression associated with increased...

journal_title：Immunology letters

authors： Park SY,Lee SW,Baek SH,Lee SJ,Lee WS,Rhim BY,Hong KW,Kim CD

更新日期：2011-05-01 00:00:00

abstract：:Phagocytosis of latex beads by peritoneal macrophages was examined by means of flow cytometry (FCM). This assay revealed that adrenocorticotropic hormone (ACTH) suppressed phagocytosis in a dose-dependent manner. ACTH (1-24) was more suppressive than ACTH (1-39). Control phagocytosis was partially suppressed in Ca(2+)...

journal_title：Immunology letters

authors： Ichinose M,Sawada M,Maeno T

更新日期：1994-10-01 00:00:00

abstract：:IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releas...

journal_title：Immunology letters

authors： Rasmussen P,Spillner E,Hoffmann HJ

更新日期：2019-06-01 00:00:00

abstract：:A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1 infection, are triggered by the chemokines, a family of secreted and structurally related chemoattractant proteins that bind to class A-specific seven-transmembrane receptors l...

journal_title：Immunology letters

authors： Muñoz LM,Holgado BL,Martínez-A C,Rodríguez-Frade JM,Mellado M

更新日期：2012-07-30 00:00:00

abstract：:This study aimed to investigate the influence of physical activity in innate immunity to conduce to an effective antitumoral immune response analyzing the phenotype and activation status of infiltrating cells. We analysed the intracellular cytokines and the transcription factors of tumor infiltrating lymphocytes (TILS...

journal_title：Immunology letters

authors： Bianco TM,Abdalla DR,Desidério CS,Thys S,Simoens C,Bogers JP,Murta EFC,Michelin MA

更新日期：2017-10-01 00:00:00

abstract：:Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...

journal_title：Immunology letters

authors： Correa SG,Riera CM

更新日期：1991-04-01 00:00:00

abstract：:There is increasing evidence for the role of basophils in allergic bronchial asthma. We studied the potential role of basophils in the pathogenesis of post-exercise-induced bronchoconstriction by measuring the histamine release from basophils both spontaneously and following ConA, FMLP, anti-IgE and TPA treatment. Two...

journal_title：Immunology letters

authors： Kivity S,Schwarz I,Agami O,Topilsky M,Fireman E

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Diabetic neuropathy (DN) is one of the microvascular complications of diabetes that leads to peripheral sensorimotor and autonomic nervous system damages. In this study, we first examined the expression of lncRNA NEAT-1 and its downstream microRNAs, miR-183-5p, miR-433-3p, and then examined mRNA expression o...

journal_title：Immunology letters

authors： Asadi G,Varmaziar FR,Karimi M,Rajabinejad M,Ranjbar S,Karaji AG,Salari F,Hezarkhani LA,Rezaiemanesh A

更新日期：2021-01-25 00:00:00

abstract：:Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...

journal_title：Immunology letters

authors： Leksa V,Ilková A,Vičíková K,Stockinger H

更新日期：2017-10-01 00:00:00

abstract：:Cloned human T-cell lines were produced by limiting dilution of lymphocytes alloactivated in mixed leukocyte cultures, followed by expansion of clonal progeny with interleukin 2. Selected clones were analyzed for cell-mediated cytotoxicity (CTX) against a variety of targets susceptible or resistant to lytic attack by ...

journal_title：Immunology letters

authors： Pawelec G,Hadam M,Müller C,Wernet P

更新日期：1982-05-01 00:00:00

abstract：:Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that ...

journal_title：Immunology letters

authors： Misra N,Selvakumar M,Singh S,Bharadwaj M,Ramesh V,Misra RS,Nath I

更新日期：1995-12-01 00:00:00

abstract：:Chagas' disease is accompanied by severe anemia and oxidative stress, which may contribute to mortality. In this study, we investigated the role of 5-lipoxygenase (5-LO) in the control of parasitism and anemia associated with oxidative damage of erythrocytes in experimental Trypanosoma cruzi infection. Wild-type C57BL...

journal_title：Immunology letters

authors： Borges CL,Cecchini R,Tatakihara VL,Malvezi AD,Yamada-Ogatta SF,Rizzo LV,Pinge-Filho P

更新日期：2009-03-24 00:00:00

abstract：:Stimulation of tonsillar B-lymphocytes with CD40 antibodies and IL-4 leads to homotypic adhesion, proliferation, and differentiation into Ig-producing cells. It also leads to the production of IL-6, a pleiotropic cytokine involved in B-cell maturation and differentiation. To assess the importance of IL-6 in the differ...

journal_title：Immunology letters

authors： Björck P,Larsson S,Andäng M,Ahrlund-Richter L,Paulie S

更新日期：1998-03-01 00:00:00

abstract：:A docile substrain of lymphocytic choriomeningitis virus (LCMV) causes a persistent infection in adult C3HeB mice and induces a severe autoimmune hemolytic anemia (AIHA) which is maximal around three weeks post infection (PI). Evaluations of serum immunoglobulin levels of these mice demonstrated grossly elevated IgG2a...

journal_title：Immunology letters

authors： Stellrecht KA,Vella AT

更新日期：1992-02-15 00:00:00

abstract：:The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Løac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention,...

journal_title：Immunology letters

authors： Norazmi MN,Suarn S

更新日期：1994-12-01 00:00:00

abstract：:Molecular chaperones (heat shock proteins, Hsp-s) play a pleiotropic role in immunological functions. Hsp-s participate in the presentation of peptide antigens, folding of several immunologically important proteins, such as the MHC, and in the maintenance of the activation-competent conformation of key signaling molec...

journal_title：Immunology letters

authors： Sreedhar AS,Nardai G,Csermely P

更新日期：2004-03-29 00:00:00

abstract：:Natural anti-cholesterol antibodies (ACHAs) exist in mammalian species, moreover their level sensitively changes in pathological situations, such as atherosclerosis or HIV infection. The conditions of their production and functional role, however, still remained ill defined. Recently we developed IgG3 type monoclonal ...

journal_title：Immunology letters

authors： Izsepi E,Balogh A,Farkas A,Molnar A,Solymos E,Toth EA,Csepanyi-Komi R,Matko J

更新日期：2012-03-30 00:00:00

abstract：:The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...

journal_title：Immunology letters

authors： Dziegielewska KM,Andersen NA,Saunders NR

更新日期：1998-01-01 00:00:00

abstract：:The early thymic precursor population of adult mice (low CD4 precursor) has the potential to produce T cells, B cells and dendritic cells if transferred into the appropriate inductive environment of an irradiated recipient. To assess its developmental potential in vitro, this population was isolated and cultured, alon...

journal_title：Immunology letters

authors： Saunders DJ,Georgiou HM,Wu L,Shortman K

更新日期：1995-07-01 00:00:00

abstract：:Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, an...

journal_title：Immunology letters

authors： McCullough KC,Pullen L,Parkinson D

更新日期：1992-01-01 00:00:00

abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

journal_title：Immunology letters

authors： Karimabad MN,Falahati-Pour SK,Hassanshahi G,Koochakzadeh L

更新日期：2017-08-26 00:00:00