A novel monoclonal antibody recognizing human thymocytes and B-cell chronic lymphocytic leukemia cells.

abstract：:A direct correlation between the constitutive expression of IL-1 alpha and reduced tumorigenicity of fibrosarcomas was observed. This was established in fibrosarcoma cell lines which produce IL-1 alpha 'spontaneously', possibly as an aberration of oncogene-mediated transformation or upon IL-1 alpha gene transfer. In f...

journal_title：Immunology letters

authors： Apte RN,Douvdevani A,Zoller M,White RM,Dvorkin T,Shimoni N,Fima E,Hacham M,Huleihel M,Benharroch D

更新日期：1993-12-01 00:00:00

abstract：:We have recently generated CD4 clones from BALB/c mice immunized with a plasmid DNA containing the gene encoding for the catalytic domain of trans-sialidase, an important enzyme expressed on the surface of Trypanosoma cruzi trypomastigotes. These clones allowed us to study in vitro the interaction between T cells and ...

journal_title：Immunology letters

authors： Rodrigues MM,Ribeirão M,Boscardin SB

更新日期：2000-07-03 00:00:00

abstract：:Adoptive transfer of multivirus-specific T cell lines (MVST) is an advanced tool for immunotherapy of virus infections after hematopoietic stem cell transplantation (HSCT). Their preparation includes activation of donor virus-specific T cells by the mixture of oligopeptides derived from immunodominant antigens of seve...

journal_title：Immunology letters

authors： Roubalová K,Němečková Š,Kryštofová J,Hainz P,Pumannová M,Hamšíková E

更新日期：2020-12-01 00:00:00

abstract：:In this study the effect of PHA activation on the phosphatase activity of CD45 has been investigated in human leukemic T-cell lines. It has been found that in vivo activation of the cells with PHA resulted in 2-4-fold increase in enzyme activity. Addition of PHA to the postnuclear supernatant of cell lysates also resu...

journal_title：Immunology letters

authors： Monostori E,Hartyani Z,Ocsovszky I,Hegedus Z,Oravecz T,Kalman M,Ando I

更新日期：1994-10-01 00:00:00

abstract：:CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a 'primary' cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-92...

journal_title：Immunology letters

authors： Komatsu Y,Nawa Y,Marbrook J

更新日期：1982-01-01 00:00:00

abstract：:Human milk lactotransferrin at a concentration ranging from 1 to 10 micrograms/ml stimulated up to 5 times the humoral immune response to sheep red blood cells, expressed as the number of plaque-forming cells, when injected into mice 3 h before immunization. Further, lactotransferrin-treated thymocytes given intraveno...

journal_title：Immunology letters

authors： Zimecki M,Mazurier J,Machnicki M,Wieczorek Z,Montreuil J,Spik G

更新日期：1991-09-01 00:00:00

abstract：:T cells utilize the vascular adhesion molecule E-selectin to enter inflamed skin. T cells identified by the mAb HECA-452 [cutaneous lymphocyte-associated antigen (CLA) T cells] are enriched in E-selectin ligand expressing cells. However, the proportion of CLA(+) T cells reactive with an E-selectin/Fc chimeric construc...

journal_title：Immunology letters

authors： Ni Z,Walcheck B

更新日期：2007-02-15 00:00:00

abstract：:Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...

journal_title：Immunology letters

authors： Salmond RJ,Williams R,Hirst TR,Williams NA

更新日期：2003-07-03 00:00:00

abstract：:Pentoxifylline (PTX), a methylxanthine derivative and phosphodiesterase inhibitor, is known to influence production and/or function of some cytokines. We examined the effect of PTX on the in vitro expression of cytokine genes using endotoxin- or phytohaemagglutinin (PHA)-stimulated human blood mononuclear cells. The e...

journal_title：Immunology letters

authors： Rieneck K,Diamant M,Haahr PM,Schönharting M,Bendtzen K

更新日期：1993-08-01 00:00:00

abstract：:Many details in the expression pattern of Epstein-Barr virus (EBV)-encoded proteins, their role in blast and growth transformation in infected B lymphocytes are known, but 'black holes' still exist. The two main types of virus-B lymphocyte interactions are denoted as Type I and Type III. These are characterized by the...

journal_title：Immunology letters

authors： Klein E,Teramoto N,Gogolák P,Nagy N,Björkholm M

更新日期：1999-05-03 00:00:00

abstract：:In murine models, challenge with different viral and parasitic infection is closely associated with the production of type I interferons (IFN-alpha/beta) and NK cell production of interferon-gamma (IFN-gamma). Therefore, we wished to determine if IFN-alpha/beta had a role in the regulation of NK cell production of IFN...

journal_title：Immunology letters

authors： Hunter CA,Gabriel KE,Radzanowski T,Neyer LE,Remington JS

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...

journal_title：Immunology letters

authors： Sikora J,Smycz-Kubańska M,Mielczarek-Palacz A,Bednarek I,Kondera-Anasz Z

更新日期：2018-09-01 00:00:00

abstract：:E1, E3-deleted, replication-deficient recombinant adenoviruses are widely studied as vectors for their capacity to transfer therapeutic genes in vivo. They can infect a wide variety of dividing and quiescent cells from different organs and possess a large packaging capacity. One of the major limitations in the use of ...

journal_title：Immunology letters

authors： Christ M,Lusky M,Stoeckel F,Dreyer D,Dieterlé A,Michou AI,Pavirani A,Mehtali M

更新日期：1997-06-01 00:00:00

abstract：:Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...

journal_title：Immunology letters

authors： Rossi GA,Peri C,Raynal ME,Defilippi AC,Risso FM,Schenone G,Pallestrini E,Melioli G

更新日期：2003-03-03 00:00:00

abstract：:As one studies more and more the immune systems of invertebrates their multiplicity and diversity increase. On one hand, the number of different local and systemic innate mechanisms (or cascades of mechanisms) increases with every phylum studied, on the other hand the diversity increases within each system as multiple...

journal_title：Immunology letters

authors： Du Pasquier L

更新日期：2004-03-29 00:00:00

abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...

journal_title：Immunology letters

authors： Ravindran B,Biswas S,Hussain QZ,Chaudhuri SN

更新日期：1984-01-01 00:00:00

abstract：:The biological activity of six synthetic peptides of the 124-144 region of the human interferon alpha-2 (IFN alpha-2) molecule was studied. Peptides were examined for their ability to inhibit mitogen induced proliferation of human blood cells in vitro. Only the peptide corresponding to the amino acid sequence 124-138 ...

journal_title：Immunology letters

authors： Danilkovich AV,Freze KV,Shevalier AF,Samukov VV,Kirkin AF,Gusev MV

更新日期：1992-01-01 00:00:00

abstract：:It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...

journal_title：Immunology letters

authors： Comerford I,Nibbs RJ

更新日期：2005-01-31 00:00:00

abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...

journal_title：Immunology letters

authors： van Bohemen CG,Langenberg ML,Rauws EA,Oudbier J,Weterings E,Zanen HC

更新日期：1989-01-15 00:00:00

abstract：:Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...

journal_title：Immunology letters

authors： Coll JM

更新日期：1988-05-01 00:00:00

abstract：:Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...

journal_title：Immunology letters

authors： Demopoulos CA,Tsabikakis GE,Kapoulas VM

更新日期：1981-08-01 00:00:00

abstract：:Recent data provide evidence that antigen-specific CD4+ T-cell clones or antigen-activated T-cell lines can kill antigen-presenting cells (APC). We focused our studies on monocytes acting as APC in cultures of T cells freshly isolated from peripheral blood. The presence of monocytes in culture was monitored by their a...

journal_title：Immunology letters

authors： Pryjma J,Zembala M,Baran J,Ernst M,Flad HD

更新日期：1995-06-01 00:00:00

abstract：:Two chicken monoclonal antibodies (MAbs), HU/Ch2-7 and HU/Ch6-1, against heterophil Hanganutziu-Deicher (HD) antigens with N-glycolylneuraminic acid (NeuGc) at a terminal carbohydrate were established by cell fusions using chicken B cell lines lacking thymidine kinase and spleen cells from chickens immunized with II3N...

journal_title：Immunology letters

authors： Asaoka H,Nishinaka S,Wakamiya N,Matsuda H,Murata M

更新日期：1992-03-01 00:00:00

abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...

journal_title：Immunology letters

authors： Hildgartner A,Wilflingseder D,Gassner C,Dierich MP,Stoiber H,Bánki Z

更新日期：2009-09-22 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

journal_title：Immunology letters

authors： Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

更新日期：2005-11-15 00:00:00

abstract：:In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively wer...

journal_title：Immunology letters

authors： Wysoczanska B,Bogunia-Kubik K,Suchnicki K,Mlynarczewska A,Lange A

更新日期：2004-02-15 00:00:00

abstract：:When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...

journal_title：Immunology letters

authors： Malbec O,Daëron M

更新日期：2012-03-30 00:00:00

abstract：:Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tes...

journal_title：Immunology letters

authors： Görög G,Laskay T,Petrányi GG

更新日期：1985-01-01 00:00:00

abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...

journal_title：Immunology letters

authors： Aksyonov A,Mitrokhin VM,Mladenov MI

更新日期：2015-09-01 00:00:00

abstract：:The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...

journal_title：Immunology letters

authors： Gern L,Rais O,Capiau C,Hauser P,Lobet Y,Simoen E,Voet P,Pêtre J

更新日期：1994-03-01 00:00:00