Abstract：
:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement effect was more pronounced in the sera of hyperimmune monkeys on further injection of antigen or parasites. It was also noticeable in the sera during primary drug-suppressed P. knowlesi infection and appeared to have a bearing on the immune status of the animals to rechallenge. The use of a soluble antigen prepared from P. knowlesi infected erythrocytes was found to be essential in IHA test to demonstrate the 2-ME enhancement effect. Antigen prepared from freed parasites (commonly used) failed to show a similar effect in IHA. The possible role of certain T-lymphocyte products - antigen binding, non-agglutinating, 2-ME sensitive molecules - in malarial immunology has been proposed.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Ravindran B,Biswas S,Hussain QZ,Chaudhuri SNdoi
10.1016/0165-2478(84)90090-7subject
Has Abstractpub_date
1984-01-01 00:00:00pages
329-33issue
6eissn
0165-2478issn
1879-0542pii
0165-2478(84)90090-7journal_volume
7pub_type
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