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Identification of IL-10-secreting CD8+CD28-PD-1+ regulatory T cells associated with chronic hepatitis C virus infection.

Abstract：

:CD8+CD28- regulatory T cells (Tregs) play important roles in chronic viral infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV)-specific CTLs. However, little is known regarding the role of CD8+CD28-PD1+ T cells in hepatitis C. Herein, we found that the frequency of CD8+CD28-PD1+, but not CD8+CD28-PD1- T cells, correlated with markers of chronic hepatitis C virus (HCV) infection and the response to treatment. Our results showed that CD8+CD28-PD1+ T cells were significantly elevated in chronic HCV-infected patients and there was a distinct correlation between the frequency of CD8+CD28-PD1+ T cells and serum levels of HCV RNA. During a 48-week course of treatment with peg-IFN-a2a plus ribavirin, dynamic changes in the frequencies of CD8+CD28-PD1+ T cells were observed, associated with the virologic response. IL-10 secretion may explain the suppressive function of CD8+CD28-PD1+ T cells in chronic HCV-infected patients. Overall, our study demonstrates that PD-1 is an important marker of CD8+CD28- Tregs in chronic HCV infection. Thus, the frequency and regulatory function of CD8+CD28-PD1+ T cells play vital roles in HCV infection and the response to treatment.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Wang W,Tong Z,Zhong J,Zhang L,Zhang H,Su Y,Gao B,Zhang C

doi

10.1016/j.imlet.2018.07.008

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

16-22

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(18)30221-9

journal_volume

202

pub_type

杂志文章

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