Abstract:
:Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytokines present. All three members of this superfamily: TGF-betas, bone morphogenetic proteins (BMPs) and Activins, have been shown to be expressed in the thymus suggesting their potential role as regulators of the T lymphocyte differentiation process. Although initial reports described the role of TGF-beta in controlling specific checkpoints during thymocyte development, recent data has provided new evidence on the role of BMPs and Activins in this process. This review provides new insights on the function of members of the TGF-beta superfamily at different stages of thymocyte development.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Licona-Limón P,Soldevila Gdoi
10.1016/j.imlet.2006.12.010subject
Has Abstractpub_date
2007-03-15 00:00:00pages
1-12issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(07)00004-1journal_volume
109pub_type
杂志文章,评审abstract:INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...
journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90035-0
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journal_title:Immunology letters
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doi:10.1016/j.imlet.2004.03.006
更新日期:2004-05-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2021.01.001
更新日期:2021-01-06 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90237-i
更新日期:1992-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90124-7
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2004-07-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00071-8
更新日期:2002-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.015
更新日期:2014-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.06.005
更新日期:2016-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.10.003
更新日期:2010-01-04 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90008-c
更新日期:1992-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90220-i
更新日期:1992-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90169-4
更新日期:1994-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00290-0
更新日期:2003-03-03 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90126-9
更新日期:1992-02-15 00:00:00
abstract::Interleukin 1 beta (IL1 beta) is an inducible polypeptide with many roles in host defence and homoeostasis. It has also been implicated as a mediator of infectious, inflammatory and autoimmune diseases, and the kinetics of its production are relevant to an understanding of the pathogenesis of these conditions. We repo...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90172-7
更新日期:1991-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.06.002
更新日期:2014-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(99)00024-3
更新日期:1999-05-03 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.05.010
更新日期:2017-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02602-8
更新日期:1996-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2007.04.013
更新日期:2007-07-31 00:00:00
abstract::There is increasing evidence for the role of basophils in allergic bronchial asthma. We studied the potential role of basophils in the pathogenesis of post-exercise-induced bronchoconstriction by measuring the histamine release from basophils both spontaneously and following ConA, FMLP, anti-IgE and TPA treatment. Two...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90026-4
更新日期:1994-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90122-7
更新日期:1986-08-01 00:00:00
abstract::To investigate the in vivo role of complement component C5 it is common to compare the inflammatory response between C5-normal and C5-deficient inbred mice strains. Nevertheless, it should be expected that differences in the genetic backgrounds between those strains may affect several physiological parameters, complic...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.02.010
更新日期:2014-05-01 00:00:00
abstract::Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.06.009
更新日期:2015-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.11.007
更新日期:2010-01-18 00:00:00
abstract::Stromal cells have been considered for a long time essentially as a structural component organizing tissue architecture, including those of secondary lymphoid organs. More recently, highly specialized stromal cell subsets were shown to differentially organize immune cell recruitment, survival, and differentiation with...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.02.005
更新日期:2019-11-01 00:00:00
abstract::Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00043-5
更新日期:1995-05-01 00:00:00