Cloned human T-cell lines with allospecific or natural killer-like cytotoxicity.

abstract：:The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...

journal_title：Immunology letters

authors： Rayfield LS,Smith TA,Andrews SJ,Bergmeier LA

更新日期：1989-01-15 00:00:00

abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

journal_title：Immunology letters

authors： Pappalardo E,Zingale LC,Cicardi M

更新日期：2003-05-01 00:00:00

abstract：:Antibody-like molecules were formed by artificial recombination of proteolytic IgG fragments (Fab' with anti-SRBC activity, and Fc) and used for studies concerning the complement fixation. Such molecules, when composed of single Fab' bound to Fc fragment appeared inactive, while species containing two Fab' fragments r...

journal_title：Immunology letters

authors： Rybarska J,Konieczny L,Bobrzecka K,Laidler P

更新日期：1982-05-01 00:00:00

abstract：:Thymocyte conditioned medium (TCM) was prepared using 2 lots of fetal calf, and 1 lot each of horse and rabbit sera. The 4 TCM and the respective sera alone were compared in their ability to support primary in vitro sensitization to sheep red blood cells (SRBC) as assayed by direct plaque formation. As would be expect...

journal_title：Immunology letters

authors： White LL,Smith RA

更新日期：1987-01-01 00:00:00

abstract：:CD27, which belongs to the TNF receptor family, is a costimulatory molecule that participates in T-cell activation. Unlike costimulatory molecules such as OX40 and 4-1BB, little is known about the role CD27 plays a role in the development of experimental diseases. We asked whether CD27 and its ligand CD70 participate ...

journal_title：Immunology letters

authors： Sumi T,Ishida W,Ojima A,Kajisako M,Sakanishi T,Yagita H,Fukushima A

更新日期：2008-08-15 00:00:00

abstract：:A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and...

journal_title：Immunology letters

authors： Bamford AI,Douglas A,Friede T,Stevanovic S,Rammensee HG,Adair BM

更新日期：1995-02-01 00:00:00

abstract：:Callithrix jacchus, the common marmoset, is a small new world primate that is considered effective as an experimental animal model for various human diseases. In this study, we generated monoclonal antibodies (mAbs) against common marmoset lymphocytes for immunological studies on the common marmoset. We established fi...

journal_title：Immunology letters

authors： Ito R,Maekawa S,Kawai K,Suemizu H,Suzuki S,Ishii H,Tanioka Y,Satake M,Yagita H,Habu S,Ito M

更新日期：2008-12-22 00:00:00

abstract：:A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic ori...

journal_title：Immunology letters

authors： Damjanovich S,Mátyus L,Damjanovich L,Bene L,Jenei A,Matkó J,Gáspár R,Szöllösi J

更新日期：2002-06-03 00:00:00

abstract：:For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...

journal_title：Immunology letters

authors： Thomé R,Lopes SC,Costa FT,Verinaud L

更新日期：2013-06-01 00:00:00

abstract：:Retroplacental blood lymphocytes (RPL) obtained from women without complications at the term delivery were studied for proliferative response to mitogens and surface phenotype and were compared with autologous peripheral blood lymphocytes (PBL). Proliferation of RPL induced by phytohemagglutinin (PHA) was significantl...

journal_title：Immunology letters

authors： Yoshida M,Kanzaki H,Tokushige M,Sato S,Wang HS,Uchida A,Kasakura S,Mori T

更新日期：1988-03-01 00:00:00

abstract：:We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...

journal_title：Immunology letters

authors： Blank M,Smorodinsky IN,Keydar I,Chaitchik S,Shoenfeld Y

更新日期：1991-04-01 00:00:00

abstract：:The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...

journal_title：Immunology letters

authors： Schreiber HA,Sandor M

更新日期：2010-05-04 00:00:00

abstract：:The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...

journal_title：Immunology letters

authors： Dziegielewska KM,Andersen NA,Saunders NR

更新日期：1998-01-01 00:00:00

abstract：:Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from co...

journal_title：Immunology letters

authors： Bánki Z,Stoiber H,Dierich MP

更新日期：2005-03-15 00:00:00

abstract：:Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent ...

journal_title：Immunology letters

authors： Das MR,Gridley DS,Kettering JD

更新日期：1991-09-01 00:00:00

abstract：:A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...

journal_title：Immunology letters

authors： Fernan A,Burrows SR,Moss DJ,Saul A,Suhrbier A

更新日期：1991-11-01 00:00:00

abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...

journal_title：Immunology letters

authors： Sármay G,Koncz G,Gergely J

更新日期：1996-12-01 00:00:00

abstract：:The role of the immune system in the defense against cancer, a process termed tumor immunosurveillance, has been extensively studied. Evidence is accumulating that the molecular organization of proteins and lipids in the plasma membrane of immune cells is of critical importance. Tetraspanin proteins are expressed in t...

journal_title：Immunology letters

authors： Veenbergen S,van Spriel AB

更新日期：2011-08-30 00:00:00

abstract：:We studied CD10 Ag of neutral endopeptidase (NEP) and CD13 Ag of aminopeptidase N (APN) expression on peripheral blood mononuclear cells (PBMC) as cells activation markers and for their transendothelial migration properties in three groups of MS patients (total 58); with acute exacerbation of MS (n = 18), primary prog...

journal_title：Immunology letters

authors： Ziaber J,Baj Z,Paśnik J,Chmielewski H,Tchórzewski H

更新日期：2000-02-01 00:00:00

abstract：:Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA ...

journal_title：Immunology letters

authors： Lee TH,Essex M,Klein E,Klein G

更新日期：1986-08-01 00:00:00

abstract：:While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...

journal_title：Immunology letters

authors： Choudhry MA,Plackett TP,Schilling EM,Faunce DE,Gamelli RL,Kovacs EJ

更新日期：2003-04-03 00:00:00

abstract：:We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may refl...

journal_title：Immunology letters

authors： Hober D,Benyoucef S,Delannoy AS,De Groote D,Ajana F,Mouton Y,Wattré P

更新日期：1996-08-01 00:00:00

abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...

journal_title：Immunology letters

authors： Zhao Y,Croft M

更新日期：2012-01-30 00:00:00

abstract：:Fibrous plaques and intimal thickenings of 5 femoral and 5 iliac human arteries obtained at surgery were processed for indirect and double-labeling immunoelectron microscopy using an affinity purified rabbit IgG anti-C5b-9 neoantigen and the EBM 11 monoclonal antibody anti-human macrophages. The C5b-9 complexes were l...

journal_title：Immunology letters

authors： Rus HG,Niculescu F,Poruţiu D,Ghiurca V,Vlaicu R

更新日期：1989-03-01 00:00:00

abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...

journal_title：Immunology letters

authors： Mbarik M,Kaabachi W,Henidi B,Sassi FH,Hamzaoui K

更新日期：2015-07-01 00:00:00

abstract：:NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...

journal_title：Immunology letters

authors： Trevelin SC,Shah AM,Lombardi G

更新日期：2020-05-01 00:00:00

abstract：:In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...

journal_title：Immunology letters

authors： Wirtz GH,Westfall SS

更新日期：1981-04-01 00:00:00

abstract：:Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...

journal_title：Immunology letters

authors： Gougeon ML,Lecoeur H,Sasaki Y

更新日期：1999-03-01 00:00:00

abstract：:Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using 70Z/3 pre-B cell line. The FoxO1 knockdown 70Z/3 cells (70Z/3-KD cells) showed the down-regulated expression of i...

journal_title：Immunology letters

authors： Li Z,Zhang N,Hui F,Zahid D,Zheng W,Xu X,Li W

更新日期：2019-12-01 00:00:00

abstract：:As shown earlier, the cells transformed in vitro by several different oncogenes, or spontaneously, during in vivo growth in normal hosts would be gradually replaced by the highly-tumorigenic descendants co-expressing high H2O2-catabolizing and PGE2-releasing activities. Acquisition of (H2O2(CA) + PGE(S)) phenotype pro...

journal_title：Immunology letters

authors： Deichman G,Dyakova N,Kashkina L,Matveeva V,Uvarova E

更新日期：1999-10-01 00:00:00