Inhibition of HLA B8-restricted recognition by unrelated peptides: evidence for allosteric inhibition.

abstract：BACKGROUND:Omalizumab therapy was found to be safe and effective as an add-on therapy for patients with poorly controlled severe asthma. Although several studies over the last decade have demonstrated its efficacy in other Immunoglobulin E related diseases, its use in such conditions is off-label. OBJECTIVE:This study...

journal_title：Immunology letters

authors： Cavaliere C,Begvarfaj E,Incorvaia C,Sposato B,Brunori M,Ciofalo A,Greco A,de Vincentiis M,Masieri S

更新日期：2020-11-01 00:00:00

abstract：:The phenomenon of virus neutralization is a function of three variables: the antibody (Ab), the virus and the target cell. Variation in any one of these parameters may drastically affect the results of assays for neutralization. In focusing on the virus as a variable in assays for the neutralization of HIV-1, it has b...

journal_title：Immunology letters

authors： Zolla-Pazner S

更新日期：1996-06-01 00:00:00

abstract：:The contribution of T cell precursors from the thymus and the bone marrow to the pool of intestinal intraepithelial lymphocvtes (IELs) has been studied in a system using donor cells from enhanced-green fluorescent protein (EGFP+ ) transgenic mice a doptively transferred into EGFP- recipient mice. Consistent with previ...

journal_title：Immunology letters

authors： Bagriacik EU,Okabe M,Klein JR

更新日期：2000-12-01 00:00:00

abstract：:Phagolysis of apoptotic eosinophils plays an important role in the successful resolution of asthmatic inflammation. However, little is known about underlying mechanisms. Our aim is to investigate whether annexin I is involved in the dexamethasone-mediated enhancement of phagolysis of apoptotic eosinophils by A549 cell...

journal_title：Immunology letters

authors： Wang C,Wang J,Guo HF,Liu RY

更新日期：2007-08-15 00:00:00

abstract：:Tumor cells have been used as the tumor antigen sources for developing cancer vaccines. Due to their low immunogenicity, tumor antigens are combined with various adjuvants to enhance immunogenicity of cancer vaccines. Among them, a natural killer T cell (NKT)-ligand, α-galactosylceramide (αGC) has been reported as a p...

journal_title：Immunology letters

authors： Hong S,Lee H,Jung K,Lee SM,Lee SJ,Jun HJ,Kim Y,Song H,Bogen B,Choi I

更新日期：2013-11-01 00:00:00

abstract：:While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...

journal_title：Immunology letters

authors： Ohno H,Ogawa M,Nishikawa S,Hayashi S,Kunisada T,Nishikawa S

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...

journal_title：Immunology letters

authors： Afkari B,Babaloo Z,Dolati S,Khabazi A,Jadidi-Niaragh F,Talei M,Shanehbandi D,Mahmoudi S,Hazhirkarzar B,Sakhinia E

更新日期：2018-02-01 00:00:00

abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...

journal_title：Immunology letters

authors： Troye-Blomberg M,Lepers JP,Sjöberg K,Rahalimalala L,Larsson A,Olerup O,Perlmann P

更新日期：1994-12-01 00:00:00

abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...

journal_title：Immunology letters

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Kawakami Y,Kusaka M,Kita S,Ueki A

更新日期：2000-05-01 00:00:00

abstract：:CD8+CD28- regulatory T cells (Tregs) play important roles in chronic viral infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV)-specific CTLs. However, little is known regarding the role of CD8+CD28-PD1+ T cells in hepatitis C. Herein, we found that the frequency of CD8+CD28-PD1+, but n...

journal_title：Immunology letters

authors： Wang W,Tong Z,Zhong J,Zhang L,Zhang H,Su Y,Gao B,Zhang C

更新日期：2018-10-01 00:00:00

abstract：:T and B cell receptor repertoires are diversified by variable region gene rearrangement and selected based on functionality and lack of self-reactivity. Repertoires can also be defined based on phenotype and function rather than receptor specificity - such as the diversity of T helper cell subsets. Natural killer (NK)...

journal_title：Immunology letters

authors： Mehr R,Sternberg-Simon M,Michaeli M,Pickman Y

更新日期：2012-11-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...

journal_title：Immunology letters

authors： Huang H,Vangay P,McKinlay CE,Knights D

更新日期：2014-12-01 00:00:00

abstract：:The cell-surface glycoproteins encoded by the major histocompatibility complex (MHC) bind to processed foreign antigens and present them to T lymphocytes. Two classes of MHC molecules and their corresponding gene sequences have been extensively studied in eutherian mammals and birds, but data on the marsupial MHC are ...

journal_title：Immunology letters

authors： Lam MK,Belov K,Harrison GA,Cooper DW

更新日期：2001-02-01 00:00:00

abstract：:We have described a monoclonal antibody with specificity for permeability-altered drug-resistant cells. This gamma G2b antibody was characterized by antibody-mediated complement-dependent cytotoxicity and by immunofluorescence analysis using a flow cytometer-cell sorter. Further experiments with the flow cytometer sho...

journal_title：Immunology letters

authors： O'Hara CJ,Price GB

更新日期：1982-07-01 00:00:00

abstract：:A quantitative approach was applied to the study of in vivo expression of foreign genes introduced into mice by ballistic transfection. Because in some cases one must take into account both the level of synthesized protein and that of antibodies to it, we derived the equation which allows to calculate the exact quanti...

journal_title：Immunology letters

authors： Rodin DV,Kolesnikov VA,Zelenina IA,Zelenin AV,Deyev SM

更新日期：2000-11-01 00:00:00

abstract：:A murine monoclonal antibody (IgG) has been generated that binds to DNA modified with osmium tetroxide in the presence of 2,2'-bipyridine and does not interact with unmodified DNA. Reactivity of the antibody was tested by gel retardation assay, ELISA, dot-binding assay and immunoblotting. The results obtained suggest ...

journal_title：Immunology letters

authors： Kabakov AE,Podgorodnichenko VK,Poverenny AM

更新日期：1991-09-01 00:00:00

abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

journal_title：Immunology letters

authors： Kaslow DC,Kumar S

更新日期：1996-07-01 00:00:00

abstract：:Administration of opioids that bind to the classical mu opioid receptor has been shown to lead to unintended alterations in immune function. Traditionally, altered immune function has been investigated with circulating immune cells. Effects of mu agonists on intestinal epithelial immune function have not been describe...

journal_title：Immunology letters

authors： Neudeck BL,Loeb JM

更新日期：2002-12-03 00:00:00

abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...

journal_title：Immunology letters

authors： Haynes L,Moynihan JA,Cohen N

更新日期：1990-12-01 00:00:00

abstract：:ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...

journal_title：Immunology letters

authors： Gergely J,Pecht I,Sármay G

更新日期：1999-05-03 00:00:00

abstract：:The antibody (Ab) response induced by DNA-based immunization was compared in various strains of inbred, H-2 congenic and outbred mice with different haplotypes of mouse major histocompatibility complex (H-2). Two different plasmid expression vectors encoding Aequorea victoria green fluorescent protein (GFP) or Escheri...

journal_title：Immunology letters

authors： Ito K,Takeuchi Y,Ito K,Kato S

更新日期：2000-11-01 00:00:00

abstract：:SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...

journal_title：Immunology letters

authors： Cinader B,Clandinin MT,Koh SW,Brown WR,Ramsay CA

更新日期：1986-03-01 00:00:00

abstract：:Cell-surface 5'-nucleotidase was assayed by incubating intact cells with 5' [3H]AMP in iso-osmotic buffer and measuring [3H]adenosine production. The activity of cell surface 5'-nucleotidase in small resting lymphocytes and in cells of the B cell line BCL1 was 5.7 and 1.1 nmol/min/mg protein respectively at 37 degrees...

journal_title：Immunology letters

authors： Hauschildt S,Bessler WG

更新日期：1988-09-01 00:00:00

abstract：:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

journal_title：Immunology letters

authors： Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

更新日期：1987-04-01 00:00:00

abstract：:We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may refl...

journal_title：Immunology letters

authors： Hober D,Benyoucef S,Delannoy AS,De Groote D,Ajana F,Mouton Y,Wattré P

更新日期：1996-08-01 00:00:00

abstract：:Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in t...

journal_title：Immunology letters

authors： Jhun J,Min HK,Na HS,Kwon JY,Ryu J,Cho KH,Choi J,Jung K,Lee SY,Kim SJ,Yang CW,Park SH,Cho ML

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Infantile hemangiomas (IHs) are the most common benign tumors of childhood. They are characterized by a unique clinical course with two phases, proliferation and involution, which are followed by regression. The therapy of infantile hemangiomas was revolutionized in 2008 by the introduction of propranolol, h...

journal_title：Immunology letters

authors： Wnęk A,Andrzejewska E,Kobos J,Taran K,Przewratil P

更新日期：2017-05-01 00:00:00

abstract：:Antibody-like molecules were formed by artificial recombination of proteolytic IgG fragments (Fab' with anti-SRBC activity, and Fc) and used for studies concerning the complement fixation. Such molecules, when composed of single Fab' bound to Fc fragment appeared inactive, while species containing two Fab' fragments r...

journal_title：Immunology letters

authors： Rybarska J,Konieczny L,Bobrzecka K,Laidler P

更新日期：1982-05-01 00:00:00

abstract：:Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V.P. Zav'yalov and A.I. Denesyuk (1982) Immunol. Lett. 4, 7-14) allowed us to conclude that a dominant secondary struc...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1985-01-01 00:00:00

abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

journal_title：Immunology letters

authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

更新日期：2013-05-01 00:00:00