Abstract：
BACKGROUND:Omalizumab therapy was found to be safe and effective as an add-on therapy for patients with poorly controlled severe asthma. Although several studies over the last decade have demonstrated its efficacy in other Immunoglobulin E related diseases, its use in such conditions is off-label. OBJECTIVE:This study aimed to assess the effectiveness of long-term therapy with Omalizumab in patients with persistent severe allergic rhinitis and inadequately controlled severe asthma. METHODS:Patients with poorly controlled severe asthma and persistent allergic rhinitis were enrolled and treated with Omalizumab for 36 months with every four-week subcutaneous administration. The efficacy assessment included the severity of AR symptoms every six months using Visual Analogue Scale, Asthma Control Test, nasal endoscopy, spirometry, and biomarkers (blood eosinophils and neutrophils, fractional exhaled nitric oxide, total IgE). RESULTS:Eleven patients aged between 26 and 70 years were enrolled, and 10 completed the study. A significant improvement of allergic rhinitis symptoms, Asthma Control Test, and lung function was observed. There was also a reduction in the status of the biomarkers at the end of the study. CONCLUSION:Long-term therapy with Omalizumab was effective and safe in treating severe persistent allergic rhinitis and concomitant asthma.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Cavaliere C,Begvarfaj E,Incorvaia C,Sposato B,Brunori M,Ciofalo A,Greco A,de Vincentiis M,Masieri Sdoi
10.1016/j.imlet.2020.08.002subject
Has Abstractpub_date
2020-11-01 00:00:00pages
81-87eissn
0165-2478issn
1879-0542pii
S0165-2478(20)30365-5journal_volume
227pub_type
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