A monoclonal antibody to DNA modified with osmium tetroxide/2,2'-bipyridine.

abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...

journal_title：Immunology letters

authors： Troye-Blomberg M,Lepers JP,Sjöberg K,Rahalimalala L,Larsson A,Olerup O,Perlmann P

更新日期：1994-12-01 00:00:00

abstract：INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...

journal_title：Immunology letters

authors： Chen Y,McKenna GJ,Ong C,Mui AL,Chung SW

更新日期：2002-04-01 00:00:00

abstract：:A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...

journal_title：Immunology letters

authors： Kanbour A,Macpherson TA,Kunz HW,Gill TJ 3rd

更新日期：1987-12-01 00:00:00

abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...

journal_title：Immunology letters

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Kawakami Y,Kusaka M,Kita S,Ueki A

更新日期：2000-05-01 00:00:00

abstract：:The monoclonal antibody 3A35 which binds mouse polymorphonuclear leucocytes (PMN) and monocytes was injected intravenously (i.v.) into normal mice. A great diminution of circulating PMN was observed. The percentage of PMN passed through a minimum (2.5%) 20 min after antibody injection and returned to normal value (18....

journal_title：Immunology letters

authors： Beurton D,Collet B,Martin A,Toujas L,Bourel D,Genetet B

更新日期：1985-01-01 00:00:00

abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...

journal_title：Immunology letters

authors： Leifer CA,McConkey C,Li S,Chassaing B,Gewirtz AT,Ley RE

更新日期：2014-12-01 00:00:00

abstract：:Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...

journal_title：Immunology letters

authors： Salmond RJ,Williams R,Hirst TR,Williams NA

更新日期：2003-07-03 00:00:00

abstract：:We infected umbilical cord blood lymphocytes (CBL) with EBV in vitro. Analysis of the cell population in 3- and 6-day-old cultures showed a relative increase of B cells and outgrowth of B cells after prolonged culture period. The immunomodulator PSK was added to parallel cultures. In these cultures, B cell growth was ...

journal_title：Immunology letters

authors： Liu A,Klein G,Bandobashi K,Klein E,Nagy N

更新日期：2002-03-01 00:00:00

abstract：:We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...

journal_title：Immunology letters

authors： Kanai Y,Isonishi S,Katagiri T,Koizumi T,Miura K,Kurosawa Y

更新日期：1990-03-01 00:00:00

abstract：:Treatment of purified human C5 with hydrogen peroxide leads to a reduction of functional activity in the classical immune haemolysis assay. The effect of H2O2 is enhanced by traces of iron-EDTA, and becomes even stronger when ascorbic acid is present in addition. The enhancement by iron and protective effects of vario...

journal_title：Immunology letters

authors： von Zabern WV,Hesse D,Nolte R,Haller Y

更新日期：1987-02-01 00:00:00

abstract：:Fibrous plaques and intimal thickenings of 5 femoral and 5 iliac human arteries obtained at surgery were processed for indirect and double-labeling immunoelectron microscopy using an affinity purified rabbit IgG anti-C5b-9 neoantigen and the EBM 11 monoclonal antibody anti-human macrophages. The C5b-9 complexes were l...

journal_title：Immunology letters

authors： Rus HG,Niculescu F,Poruţiu D,Ghiurca V,Vlaicu R

更新日期：1989-03-01 00:00:00

abstract：:Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that ...

journal_title：Immunology letters

authors： Misra N,Selvakumar M,Singh S,Bharadwaj M,Ramesh V,Misra RS,Nath I

更新日期：1995-12-01 00:00:00

abstract：:The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Løac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention,...

journal_title：Immunology letters

authors： Norazmi MN,Suarn S

更新日期：1994-12-01 00:00:00

abstract：:Applying 2 M KBr, membranes of Ehu were solubilized. By C3-affinity chromatography an activity could be isolated that inhibited the immune adherence reaction and C3b-dependent rosette formation. Since this material did not agglutinate EAC14oxy23b we termed it monovalent C3b receptor (mC3bR). PAGE and SDS-PAGE and stai...

journal_title：Immunology letters

authors： Mussel HH,Ehlen T,Schmitt M,Kazatchkine MD,Neyses L,Dierich MP

更新日期：1982-01-01 00:00:00

abstract：:Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk factor for child type 1 diabetes mellitus development. To test the role of IL-18 gene polymorphism in predisposition to adult type 1 diabetes (T1DM) and latent autoimmune diabetes in adults (LADA), we analysed SNPs at position -607 (C/A) and ...

journal_title：Immunology letters

authors： Novota P,Kolostova K,Pinterova D,Novak J,Treslova L,Andel M,Cerna M

更新日期：2005-01-31 00:00:00

abstract：:We have prepared a retroviral expression construct, pPS-IL-2, in which human IL-2 cDNA has been inserted into the polylinker region, and have used the retroviral vector to introduce the functional IL-2 gene into a fibroblast cell line, RAT-1. Peritumoral administration of IL-2-producing RAT-1 cells into congenitally a...

journal_title：Immunology letters

authors： Bubenik J,Voitenok NN,Kieler J,Prassolov VS,Chumakov PM,Bubenikova D,Simova J,Jandlova T

更新日期：1988-12-01 00:00:00

abstract：:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heteroge...

journal_title：Immunology letters

authors： Wu L,D'Amico A

更新日期：1994-05-01 00:00:00

abstract：:The production of interleukin 1 (IL-1) by lipopolysaccharide (LPS)-stimulated myelomonocytic cell lines ML-1, THP-1 and PL-21 was significantly enhanced by the addition of insulin, insulin-like growth factor (IGF)-I or IGF-II into the cell cultures. The IL-1 activity in the supernatants from cell cultures stimulated w...

journal_title：Immunology letters

authors： Holán V,Minowada J

更新日期：1992-12-01 00:00:00

abstract：:Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...

journal_title：Immunology letters

authors： Beekman JM,van der Linden JA,van de Winkel JG,Leusen JH

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...

journal_title：Immunology letters

authors： Truxova I,Pokorna K,Kloudova K,Partlova S,Spisek R,Fucikova J

更新日期：2014-07-01 00:00:00

abstract：:In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....

journal_title：Immunology letters

authors： Kadri N,Potiron N,Ouary M,Jegou D,Gouin E,Bach JM,Lieubeau B

更新日期：2007-02-15 00:00:00

abstract：BACKGROUND:Omalizumab therapy was found to be safe and effective as an add-on therapy for patients with poorly controlled severe asthma. Although several studies over the last decade have demonstrated its efficacy in other Immunoglobulin E related diseases, its use in such conditions is off-label. OBJECTIVE:This study...

journal_title：Immunology letters

authors： Cavaliere C,Begvarfaj E,Incorvaia C,Sposato B,Brunori M,Ciofalo A,Greco A,de Vincentiis M,Masieri S

更新日期：2020-11-01 00:00:00

abstract：:Murine peritoneal macrophages were isolated by adherence and their listericidal activity assessed in the presence or absence of selected cytokines. Untreated macrophages were not highly listericidal, showing moderate killing in the first 2 h after infection, and allowed progressive microbial growth thereafter (up to 9...

journal_title：Immunology letters

authors： Denis M,Gregg EO

更新日期：1991-03-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...

journal_title：Immunology letters

authors： Guo T,Zhao L,Zhang Y,Liu G,Yao Y,Li H

更新日期：2016-12-01 00:00:00

abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...

journal_title：Immunology letters

authors： Dittes K,Gakamsky DM,Haran G,Haas E,Ojcius DM,Kourilsky P,Pecht I

更新日期：1994-05-01 00:00:00

abstract：:An effective HIV vaccine will likely need to induce potent and broad-based immunity, including CD8+ T cell responses. Hence, a quantitative assay to measure such responses in animal models will be important in the evaluation of candidate HIV vaccines. We show here that a single immunization with HIV DNA vaccines, foll...

journal_title：Immunology letters

authors： Otten GR,Chen M,Doe B,zur Megede J,Barnett S,Ulmer J

更新日期：2003-01-22 00:00:00

abstract：:Dendritic cell (DC)-based tumor vaccine is a promising therapy for malignancies. Recent studies showed greater potency with DC/tumor fusion vaccines against acute myeloid leukemia and melanoma compared with lysate-pulsed DC vaccines. We compared these two vaccine strategies against murine colon cancer and investigated...

journal_title：Immunology letters

authors： Kao JY,Zhang M,Chen CM,Chen JJ

更新日期：2005-11-15 00:00:00

abstract：:Staphylococcus aureus (S. aureus) can often lead to many life-threatening diseases. It has the ability to invade normal endovascular tissue. Acute inflammation and its resolution are important to ensure bacterial clearance and limit tissue injury. Carbon monoxide (CO) has been shown to exert anti-inflammatory effects ...

journal_title：Immunology letters

authors： Tsai MH,Yang CM,Chang KT,Chuang CC,Lin WN,Jiang RS,Wu CH,Lee IT

更新日期：2018-11-01 00:00:00

abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

journal_title：Immunology letters

authors： Pappalardo E,Zingale LC,Cicardi M

更新日期：2003-05-01 00:00:00

abstract：:A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...

journal_title：Immunology letters

authors： Fernan A,Burrows SR,Moss DJ,Saul A,Suhrbier A

更新日期：1991-11-01 00:00:00