Abstract：
:We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination revealed that KML1-7 cells cloned from the cell line KML1 were only positive for the Lys-24 (Pgp-1) phenotype, and were negative for other typical phenotypes tested, such as Thy-1, Ly-1, Ly-2, Ly-4 (L3T4) and Ly-5 (B220). This finding suggested that this line was of prothymocyte or myeloid cell lineage. From day 70 after subcutaneous inoculation of KML1-7 cells into 10-week-old MRL/Mp(-)+/+(MRL/n) mice, IgG anti-dsDNA antibodies began to replace IgM anti-dsDNA antibodies in the serum of these mice, but anticardiolipin, anti-trinitrophenyl hapten (TNP) and anti-poly(ADP-ribose) antibodies did not increase significantly. The predominant subclasses of anti-dsDNA antibodies that increased were IgG2a and IgG2b. IgG anti-dsDNA antibodies also became detectable as early as day 22 after inoculation of KML1-7 cells into MRL/l mice of 10 weeks old. The finding that in MRL/n mice the IgM isotype was increased first and was soon replaced by the IgG isotype was consistent with findings when spleen cells from MRL/n mice of 20 weeks old primed with ssDNA were cultured in the presence of conditioned medium containing a putative cytokine(s) (PC) produced by KML1-7 cells.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kanai Y,Isonishi S,Katagiri T,Koizumi T,Miura K,Kurosawa Ydoi
10.1016/0165-2478(90)90035-osubject
Has Abstractpub_date
1990-03-01 00:00:00pages
49-55issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(90)90035-Ojournal_volume
24pub_type
杂志文章abstract：:In human tumors of neuroectodermal origin cell surface expression of individual gangliosides is either increased or decreased relative to comparable normal cells. We have previously shown that gangliosides shed from melanoma cells can immunomodulate T cell activity. Monocytes/macrophages (m/m) are known to play an imp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90034-5
更新日期：1989-03-01 00:00:00
abstract：:Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. As such, it signals monocytes, macrophages and neutrophils to up-regulate phagocytic functions and to release pro-inflammatory cytokines. Despite the established role of CD14 as the main LPS receptor, the precise nature of t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.07.019
更新日期：2005-01-15 00:00:00
abstract：BACKGROUND:Vitamin D (vitD) is involved in important regulatory functions of the innate and adaptive immune system. So, it has been hypothesized that vitD might influence the course of atopic dermatitis (AD). Also obesity may have impact on immune system. The aim of our study was to investigate vitamin D status and bod...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrach...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.11.010
更新日期：2020-02-01 00:00:00
abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.05.002
更新日期：2013-05-01 00:00:00
abstract：:Applying 2 M KBr, membranes of Ehu were solubilized. By C3-affinity chromatography an activity could be isolated that inhibited the immune adherence reaction and C3b-dependent rosette formation. Since this material did not agglutinate EAC14oxy23b we termed it monovalent C3b receptor (mC3bR). PAGE and SDS-PAGE and stai...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90069-4
更新日期：1982-01-01 00:00:00
abstract：:The immunomodulating properties of a neuropeptide hormone, corticotropin-releasing factor (CRF), led us to investigate its effect on cAMP production by human peripheral blood mononuclear cells (MNC). In response to stimulation with CRF (100 nM), a statistically significant (P = 0.019) increase occurred in the amount o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90189-9
更新日期：1993-03-01 00:00:00
abstract：:A novel mutant strain of rats, LEC, exhibits an arrest of T-cell maturation from CD4+CD8+ to CD4+CD8- but not the CD4-CD8+ cells in the thymus. Nevertheless, CD4+T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell rece...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00254-o
更新日期：1995-03-01 00:00:00
abstract：:Natural anti-cholesterol antibodies (ACHAs) exist in mammalian species, moreover their level sensitively changes in pathological situations, such as atherosclerosis or HIV infection. The conditions of their production and functional role, however, still remained ill defined. Recently we developed IgG3 type monoclonal ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.01.009
更新日期：2012-03-30 00:00:00
abstract：:We describe the quantification of the absolute amounts of HLA class II mRNA and class II transactivator (CIITA) mRNA by competitive reverse transcription polymerase chain reaction in cultured synovial fibroblast-like cells (SFC) of patients with rheumatoid arthritis. High basal levels of transcription of class II mRNA...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)02712-0
更新日期：1997-06-01 00:00:00
abstract：:It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02497-2
更新日期：1996-03-01 00:00:00
abstract：:Based on the fact that monoclonal antibody (mAb) 2F5 recognizing ELDKWA-epitope on HIV-1 gp41 separately or in combination with other mAbs showed potent neutralizing activity to a wide range of primary HIV-1 isolates in vivo and in vitro, but this epitope undergoes restricted mutation. ELNKWA is a neutralizing-resista...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00298-4
更新日期：2001-01-01 00:00:00
abstract：:While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90091-f
更新日期：1993-02-01 00:00:00
abstract：BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.05.015
更新日期：2017-09-01 00:00:00
abstract：:Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with hi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.02.004
更新日期：2019-04-01 00:00:00
abstract：:Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90070-3
更新日期：1988-05-01 00:00:00
abstract：:The immunological alterations observed in chronic alcoholic patients may be due to alterations of signal transduction across the lymphocyte membrane. Upon binding of mitogens or antigens to specific plasma membrane receptors, the activation of phospholipase C leads to the hydrolysis of inositol phospholipids, producin...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00019-2
更新日期：1995-05-01 00:00:00
abstract：:CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.06.004
更新日期：2014-09-01 00:00:00
abstract：:Transplantation immunologists have long been intrigued by the natural allograft that results from normal mammalian pregnancy. Its general success contrasts with the rejection problems associated with most artifactual organ transplantation and raises intriguing questions concerning the nature of the mechanisms involved...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(88)90001-6
更新日期：1988-04-01 00:00:00
abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.11.005
更新日期：2005-04-15 00:00:00
abstract：:Human deficiency in transporter associated with antigen processing (TAP) is characterized by a very low surface expression of human leukocyte antigen (HLA) class I molecules in hematopoietic and non hematopoietic cells. Among the latter, TAP-deficient skin fibroblasts have previously been shown by us to be very sensit...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.07.010
更新日期：2006-11-15 00:00:00
abstract：:Allogeneic, H-2-incompatible irradiation chimeras (H-2d leads to H-2b) constructed with normal, unmanipulated bone marrow and with marrow-derived factors live long and do not manifest a GvH disease. Their response to primary immunization is deficient but their alloreactivity is normal. This chimeric allotolerance cann...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90003-2
更新日期：1983-04-01 00:00:00
abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2016.07.004
更新日期：2016-11-01 00:00:00
abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.09.004
更新日期：2003-12-15 00:00:00
abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90085-3
更新日期：1984-01-01 00:00:00
abstract：:Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying vi...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2011.06.008
更新日期：2011-12-30 00:00:00
abstract：:Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.03.009
更新日期：2011-08-30 00:00:00
abstract：:Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.11.015
更新日期：2008-02-15 00:00:00
abstract：:Serum antibodies reactive with intermediate filaments of the cytoskeleton (anti-IF antibodies) are often present in infectious mononucleosis, some other viral diseases, and rheumatoid arthritis. The mechanism of their production is not known, but it is possible that the formation of this and other autoantibodies resul...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90135-3
更新日期：1982-10-01 00:00:00
abstract：:The possibility of inducing immune responses to murine interleukin-4 (IL-4) and IL-13 and generating anti-cytokine monoclonal antibodies (mAbs) was studied in IL-4- and IL-13-knockout mice. The minimal doses of IL-4 or IL-13 that could induce significant anti-cytokine responses with titers of 5000-10,000 were 20 micro...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.08.005
更新日期：2006-02-15 00:00:00
