Abstract：
:It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats receiving lethal split-dose radiation and radioprotected with SCID bone marrow. We now demonstrate that, in contrast to SCID recipients of human PBL, Balb/c and C3H/HeJ recipients of 50-100 x 10(6) human PBL did not develop any EBV lymphoma during a 7-month follow-up period, but were successfully engrafted with human B and T cells. On the other hand, lymphoma developed in 90% of the C.B-17/SCID mice infused with 70 x 10(6) human PBL from the same donor. Likewise, 36% of beige/nude/xid (BNX) mice, exposed to 12 Gy TBI, radioprotected with SCID bone marrow and then transplanted with human PBL developed lymphoma. Similar results were obtained when different strains were infused with PBL of the same donor. Immunohistochemical analysis indicated that the tumor cells were of human B cell origin and expressed the EBV-encoded latent membrane protein-1 and nuclear antigen 2. While further studies are required to understand the mechanisms which suppressed outgrowth of EBV lymphoma in human --> mouse radiation chimera, compared to human --> C.B-17/SCID or human --> BNX chimera, this marked resistance offers new possibilities for transplantation of hematopoietic tissues or cells from EBV-positive donors.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Marcus H,Burakova T,Shezen E,David M,Canaan A,Lubin I,Reisner Ydoi
10.1016/0165-2478(96)02497-2subject
Has Abstractpub_date
1996-03-01 00:00:00pages
155-61issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(96)02497-2journal_volume
49pub_type
杂志文章abstract：:Lck is the principal signal-generating tyrosine kinase of the T cell activation mechanism. We have previously demonstrated that induced Lck activation outside of lipid rafts (LR) results in the rapid translocation of a fraction of Lck to LR. While this translocation predicates the subsequent production of IL-2, the me...
journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2012-02-29 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90145-g
更新日期：1990-11-01 00:00:00
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更新日期：2010-01-18 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.10.003
更新日期：2010-01-04 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.11.007
更新日期：2010-01-18 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.01.004
更新日期：2018-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2010-05-04 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2007-08-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：1995-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00266-3
更新日期：2003-03-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90138-e
更新日期：1992-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90069-2
更新日期：1989-01-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.03.007
更新日期：2017-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.12.018
更新日期：2010-02-16 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90134-1
更新日期：1982-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90099-v
更新日期：1991-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：1993-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90018-6
更新日期：1991-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1990-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90145-2
更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.05.011
更新日期：2006-08-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.02.004
更新日期：2016-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90049-1
更新日期：1988-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90244-5
更新日期：1991-01-01 00:00:00
abstract：:NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.02.009
更新日期：2020-05-01 00:00:00
