Abstract:
:Crosslinking of the B-cell receptor (BCR) for antigen to low-affinity receptors for IgG (Fc gamma RII) inhibits B-cell activation induced by BCR aggregation. The cell-triggering properties of the BCR depend on tyrosine-containing activation motifs (TAM), in the intracytoplasmic domain of its Ig alpha and Ig beta subunits. TAMs also account for the cell-triggering capabilities of the T-cell receptor (TCR) for antigen, in T lymphocytes, and of the high-affinity receptor for IgE (Fc epsilon RI), in mast cells. Using as a model, rat basophilic leukemia cells (RBL-2H3) stably transfected with cDNA encoding wild-type or mutated murine or human Fc gamma RIIB and chimeric molecules having the intracytoplasmic domain of the FcR gamma subunit or of TCR-CD3 zeta subunit, we found that the inhibitory properties of Fc gamma RII are neither restricted to B cells nor to BCR-dependent cell activation, but can be extended to other cells and, as a general rule, to TAM-dependent cell activation.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Daëron M,Malbec O,Latour S,Espinosa E,Pina P,Fridman WHdoi
10.1016/0165-2478(94)00202-3subject
Has Abstractpub_date
1995-01-01 00:00:00pages
119-23issue
2-3eissn
0165-2478issn
1879-0542pii
0165-2478(94)00202-3journal_volume
44pub_type
杂志文章,评审abstract::In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90067-z
更新日期:1990-02-01 00:00:00
abstract::The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90183-x
更新日期:1994-05-01 00:00:00
abstract::The monoclonal antibody (mAb) AHT-107 recognized a determinant distal to the interleukin 2 (IL-2) binding site on the p55 subunit of the IL-2 receptor (IL-2R) (the Tac antigen, CD25) of human T lymphoblasts, while the mAb AHT-54 recognized a determinant close to the IL-2 binding site as did the anti-Tac. The AHT-107 i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90081-3
更新日期:1989-02-01 00:00:00
abstract::The influence of pretreatment with interferon (IFN) on subsequent IFN synthesis was investigated in macrophage cultures of DBA/2 and C57BL/6 mice. The doses of IFN alpha/beta for pretreatment ranged from 10,000 U/ml to 100 U/ml and the incubation time was between 18 and 2 h. No blocking effect was observed for chemica...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90049-1
更新日期:1988-06-01 00:00:00
abstract::Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90051-5
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes. Therefore, the purpose ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.04.005
更新日期:2013-04-01 00:00:00
abstract::HLA class II molecules play pivotal roles in antigen presentation to CD4+ T cells. We investigated signaling via HLA-DR molecules expressed on CD4+ T cells. When HLA-DR or CD3 molecules on cloned CD4+ T cells were cross-linked by solid-phase mAbs, T cells proliferated, and this resulted in anergy. Whereas cross-linkin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00341-8
更新日期:2002-04-22 00:00:00
abstract::Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.10.009
更新日期:2012-12-17 00:00:00
abstract::The regulatory effect of Z-100 on the balance of Th1/Th2 cell responses in BALB/c mice bearing Meth-A fibrosarcoma was investigated. In tumor bearing mice, Th1 cytokine production (IL-2, IFN-gamma) are suppressed and Th2 cytokine production (IL-4, IL-10) are increased, as compared with those of normal mice. The admini...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00130-3
更新日期:1999-11-01 00:00:00
abstract::In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.05.012
更新日期:2017-08-01 00:00:00
abstract::The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly wi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90090-2
更新日期:1985-01-01 00:00:00
abstract::The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00156-5
更新日期:2000-04-03 00:00:00
abstract::Pretreatment with interleukin (IL)-10 inhibited the release of growth-related oncogene GRO-alpha but not of epithelial-cell derived neutrophil activating protein (ENA)-78, after injection of lipopolysaccharide (LPS) into healthy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha ...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0165-2478(01)00224-3
更新日期:2001-08-01 00:00:00
abstract::Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.017
更新日期:2014-12-01 00:00:00
abstract::Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90155-6
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVE:Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the curre...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.005
更新日期:2019-08-01 00:00:00
abstract::Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 micrograms/ml and between 3 micrograms and 1 mg/ml for immunoglobulins. The s...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90080-4
更新日期:1984-01-01 00:00:00
abstract::House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00196-7
更新日期:2003-01-02 00:00:00
abstract::In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00181-3
更新日期:1999-03-01 00:00:00
abstract::An essential key to pathogenicity in Yersinia is the presence of a 70 kb plasmid (pYV) which encodes a type-III secretion system and several virulence outer proteins whose main function is to enable the bacteria to survive in the host. Thus, a specific immune response is needed in which cytokines are engaged. The aim ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.04.007
更新日期:2004-06-15 00:00:00
abstract::We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90128-w
更新日期:1991-04-01 00:00:00
abstract::Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.09.026
更新日期:2013-11-01 00:00:00
abstract::Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2021.01.001
更新日期:2021-01-06 00:00:00
abstract::Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02602-8
更新日期:1996-09-01 00:00:00
abstract::A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90157-x
更新日期:1987-12-01 00:00:00
abstract::A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02550-3
更新日期:1996-06-01 00:00:00
abstract::Recent data suggests that autoimmune factors play an important role in the pathogenesis of atherosclerosis. In this context several autoantigens have been shown to elicit an immune response that results in accelerated atherosclerotic plaque formation. In the present study, we investigated whether elevated titers of an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00050-4
更新日期:1999-06-01 00:00:00
abstract::Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.09.007
更新日期:2015-02-01 00:00:00
abstract::MHC tetramers are used to directly enumerate and visualize the antigen-specific T lymphocyte population of interest by flow cytometry, regardless of the T lymphocyte's functional capacity. Assay sensitivity can be hindered by non-specific binding activity, which is due to the inherent interactions of CD8 and MHC. Poin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.11.016
更新日期:2005-05-15 00:00:00
abstract::Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.imlet.2019.03.003
更新日期:2019-09-01 00:00:00