Abstract:
:The production of neutralizing antibodies against the central portion of HIV-1 gp120 requires cooperation between T cell and B cell epitopes of this region. We found a motif common to the carboxyterminus of the second conserved region of HIV-1 gp120 and sequences of some human proteins, most of which participate in immune response. The sequence of gp120 of HTLV-IIIB with the highest T-cell reactivity incorporates this motif. It is suggested that the existence of this sequence motif in the central region of the HIV-1 gp120 molecule prevents the production of neutralizing antibodies against the virus in humans.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Veljković V,Metlas Rdoi
10.1016/0165-2478(90)90145-gsubject
Has Abstractpub_date
1990-11-01 00:00:00pages
193-5issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(90)90145-Gjournal_volume
26pub_type
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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更新日期:1994-05-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:1996-06-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1987-05-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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更新日期:2014-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:2007-03-15 00:00:00
abstract:BACKGROUND:Vitamin D (vitD) is involved in important regulatory functions of the innate and adaptive immune system. So, it has been hypothesized that vitD might influence the course of atopic dermatitis (AD). Also obesity may have impact on immune system. The aim of our study was to investigate vitamin D status and bod...
journal_title:Immunology letters
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更新日期:2017-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
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更新日期:1993-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.06.004
更新日期:2004-08-15 00:00:00