Efficient generation of a monoclonal antibody against the human C-type lectin receptor DCIR by targeting murine dendritic cells.

abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...

journal_title：Immunology letters

authors： Ravindran B,Biswas S,Hussain QZ,Chaudhuri SN

更新日期：1984-01-01 00:00:00

abstract：:The antigen receptors on the surface of B- and T-lymphocytes are complexes of several integral membrane proteins, essential for their proper expression and function. Recent studies demonstrated that transmembrane (TM) domains of the components of these receptors play a critical role in their association and function. ...

journal_title：Immunology letters

authors： Zidovetzki R,Rost B,Pecht I

更新日期：1998-12-01 00:00:00

abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...

journal_title：Immunology letters

authors： Moriya O,Ichikawa Y

更新日期：1984-01-01 00:00:00

abstract：:Experimental systemic lupus erythematosus (SLE), similar to that observed after immunization with the human anti-DNA mAb 16/6 Id+, could be induced in mice by injection of 16/6 Id specific T-cell lines. The above T-cell lines were exclusively CD4+ CD8- and the majority of cells expressed the Vbeta8 T-cell receptor (TC...

journal_title：Immunology letters

authors： Ruiz PJ,Waisman A,Mozes E

更新日期：1998-05-01 00:00:00

abstract：:Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...

journal_title：Immunology letters

authors： Bahrambeigi S,Molaparast M,Sohrabi F,Seifi L,Faraji A,Fani S,Shafiei-Irannejad V

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...

journal_title：Immunology letters

authors： Kőhalmi KV,Veszeli N,Cervenak L,Varga L,Farkas H

更新日期：2017-09-01 00:00:00

abstract：:Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory...

journal_title：Immunology letters

authors： Nakken B,Papp G,Bosnes V,Zeher M,Nagy G,Szodoray P

更新日期：2017-09-01 00:00:00

abstract：:The monoclonal antibody (mAb) UN2 was generated upon immunization of a Balb/c mouse with human thymocytes. mAb UN2 recognized an antigen expressed by a subpopulation of human thymocytes and peripheral blood lymphocytes. In thymus, mAb UN2 recognized cortical cells; its expression was higher on CD3bright than on CD3dim...

journal_title：Immunology letters

authors： Tassone P,Bonelli P,Tuccillo F,Turco MC,De Rosa G,Morrone G,Cecco L,Cerra M,Petrella A,Nigro M

更新日期：1994-09-01 00:00:00

abstract：:A direct correlation between the constitutive expression of IL-1 alpha and reduced tumorigenicity of fibrosarcomas was observed. This was established in fibrosarcoma cell lines which produce IL-1 alpha 'spontaneously', possibly as an aberration of oncogene-mediated transformation or upon IL-1 alpha gene transfer. In f...

journal_title：Immunology letters

authors： Apte RN,Douvdevani A,Zoller M,White RM,Dvorkin T,Shimoni N,Fima E,Hacham M,Huleihel M,Benharroch D

更新日期：1993-12-01 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

journal_title：Immunology letters

authors： Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

更新日期：2005-11-15 00:00:00

abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...

journal_title：Immunology letters

authors： Troye-Blomberg M,Lepers JP,Sjöberg K,Rahalimalala L,Larsson A,Olerup O,Perlmann P

更新日期：1994-12-01 00:00:00

abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...

journal_title：Immunology letters

authors： Dubs MC,Altschuh D,Van Regenmortel MH

更新日期：1992-01-01 00:00:00

abstract：:In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and other proinflammatory mediators of joint d...

journal_title：Immunology letters

authors： Friday SC,Fox DA

更新日期：2016-06-01 00:00:00

abstract：:Graft failure (GF) following bone marrow transplantation (BMT) in man is usually attributed to allograft rejection; however, other mechanisms of GF exist. Exposure of the developing allograft to viruses, myelotoxic drugs, and damage to the host-derived marrow stroma during graft-versus-host disease (GVHD) may all caus...

journal_title：Immunology letters

authors： Hows JM

更新日期：1991-07-01 00:00:00

abstract：:Diabetes mellitus is associated with an increased incidence of cardiovascular events and microvascular complications. Serum amyloid A (SAA), a HDL apolipoprotein is a risk marker for cardiovascular disease. A permanent increase in SAA plasma levels is observed in diabetics. Because SAA acts on leukocytes, we evaluated...

journal_title：Immunology letters

authors： Hatanaka E,Monteagudo PT,Marrocos MS,Campa A

更新日期：2007-02-15 00:00:00

abstract：:Adoptive transfer of multivirus-specific T cell lines (MVST) is an advanced tool for immunotherapy of virus infections after hematopoietic stem cell transplantation (HSCT). Their preparation includes activation of donor virus-specific T cells by the mixture of oligopeptides derived from immunodominant antigens of seve...

journal_title：Immunology letters

authors： Roubalová K,Němečková Š,Kryštofová J,Hainz P,Pumannová M,Hamšíková E

更新日期：2020-12-01 00:00:00

abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...

journal_title：Immunology letters

authors： Honti V,Kurucz E,Csordás G,Laurinyecz B,Márkus R,Andó I

更新日期：2009-09-22 00:00:00

abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...

journal_title：Immunology letters

authors： Inuzuka S,Koga S,Nishikido M,Miyata Y,Kanda S,Shimokawa I,Tanaka M,Saito Y,Kanetake H

更新日期：2002-09-02 00:00:00

abstract：:We have explored the requirements for the induction of the N-formyl-methionyl-leucyl-phenylalanine (FMLP) response in Daudi cells after anti-immunoglobulin treatment. Our results indicate that (a) induction of responsiveness to FMLP was observed in Daudi only after crosslinking of surface immunoglobulin by anti-immuno...

journal_title：Immunology letters

authors： Kalunta CI,Kaptein JS,Scott SJ,Lin CK,Gu DG,Lad PM

更新日期：1992-04-01 00:00:00

abstract：:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...

journal_title：Immunology letters

authors： Hartung HP,Toyka KV

更新日期：1983-01-01 00:00:00

abstract：:The monoclonal antibody 3A35 which binds mouse polymorphonuclear leucocytes (PMN) and monocytes was injected intravenously (i.v.) into normal mice. A great diminution of circulating PMN was observed. The percentage of PMN passed through a minimum (2.5%) 20 min after antibody injection and returned to normal value (18....

journal_title：Immunology letters

authors： Beurton D,Collet B,Martin A,Toujas L,Bourel D,Genetet B

更新日期：1985-01-01 00:00:00

abstract：:Recombinant gp120 of the HIV-1(IIIB) isolate (BH10 clone) has been mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted. A variety of studies have shown that the CD4 binding domain (CD4bd) is very well exposed in PR12 in contrast to rgp120(LAI). Us...

journal_title：Immunology letters

authors： Jeffs SA,Gorny MK,Williams C,Revesz K,Volsky B,Burda S,Wang XH,Bandres J,Zolla-Pazner S,Holmes H

更新日期：2001-12-03 00:00:00

abstract：:Human deficiency in transporter associated with antigen processing (TAP) is characterized by a very low surface expression of human leukocyte antigen (HLA) class I molecules in hematopoietic and non hematopoietic cells. Among the latter, TAP-deficient skin fibroblasts have previously been shown by us to be very sensit...

journal_title：Immunology letters

authors： Zimmer J,Poli A,Andrès E,Hanau D,Brons NH,Hentges F

更新日期：2006-11-15 00:00:00

abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

journal_title：Immunology letters

authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

更新日期：2013-05-01 00:00:00

abstract：:Ligation of both the T cell receptor (TCR) and the CD28 receptor is required for full T cell activation to occur. Engagement of the TCR in primary T cells is followed by rapid cAMP production in lipid rafts and activation of the cAMP-protein kinase A (PKA)-Csk pathway inhibiting proximal T cell signaling. However, CD2...

journal_title：Immunology letters

authors： Bjørgo E,Taskén K

更新日期：2010-03-10 00:00:00

abstract：:The effects of recombinant human interleukin 4 (rIL-4) on proliferation and differentiation on human myeloid/monocytic leukemia cell lines were examined. At high concentrations, rIL-4 had a slight enhancing effect on [3H]thymidine incorporation by U937 cells. rIL-4 markedly induced expression of the Fc epsilon recepto...

journal_title：Immunology letters

authors： Noma T,Nakakubo H,Hama K,Honjo T

更新日期：1989-06-15 00:00:00

abstract：:The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related ...

journal_title：Immunology letters

authors： Denesyuk AI,Lundell J,Zav'yalov V,Korpela T

更新日期：1994-07-01 00:00:00

abstract：:Pentoxifylline (PTX), a methylxanthine derivative and phosphodiesterase inhibitor, is known to influence production and/or function of some cytokines. We examined the effect of PTX on the in vitro expression of cytokine genes using endotoxin- or phytohaemagglutinin (PHA)-stimulated human blood mononuclear cells. The e...

journal_title：Immunology letters

authors： Rieneck K,Diamant M,Haahr PM,Schönharting M,Bendtzen K

更新日期：1993-08-01 00:00:00

abstract：:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...

journal_title：Immunology letters

authors： Seow WK,Thong YH

更新日期：1987-01-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the destruction of insulin-secreting β cells upon autoreactive T cell attack. Oral administration of autoantigens is an attractive approach to treating T1DM, but an effective carrier should be used in order to protect antigens. Lactococcu...

journal_title：Immunology letters

authors： Liu KF,Liu XR,Li GL,Lu SP,Jin L,Wu J

更新日期：2016-06-01 00:00:00