Abstract:
:Diabetes mellitus is associated with an increased incidence of cardiovascular events and microvascular complications. Serum amyloid A (SAA), a HDL apolipoprotein is a risk marker for cardiovascular disease. A permanent increase in SAA plasma levels is observed in diabetics. Because SAA acts on leukocytes, we evaluated whether the synthesis of proinflammatory cytokines and migration of neutrophils and monocytes induced by SAA is affected in diabetics. Cells, isolated from human blood, were cultured in the presence of SAA. TNF-alpha, IL-1beta, IL-8 and IL-1ra levels were measured by ELISA in the culture supernatants and in serum of subjects. Neutrophils and monocytes migration were followed in a chemotaxis chamber. We make the novel observation that neutrophils and monocytes of diabetics are more responsive to SAA for the induction of the proinflammatory cytokine IL-1beta and the proangiogenic and chemotactic protein IL-8. Incremental TNF-alpha production was also found to occur when monocytes were stimulated with SAA. Cell migration was also increased. The increased production of cytokines and increased migration of leukocytes from diabetics in response to SAA may contribute to a sustained accumulation and activation of inflammatory cells in the disease. Accordingly, the hyper-responsiveness of leukocytes to SAA may be relevant to the proinflammatory conditions associated to vascular complications in diabetic patients.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hatanaka E,Monteagudo PT,Marrocos MS,Campa Adoi
10.1016/j.imlet.2006.12.005subject
Has Abstractpub_date
2007-02-15 00:00:00pages
160-6issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(06)00282-3journal_volume
108pub_type
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
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pub_type: 杂志文章
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