Abstract:
:The effects of recombinant human interleukin 4 (rIL-4) on proliferation and differentiation on human myeloid/monocytic leukemia cell lines were examined. At high concentrations, rIL-4 had a slight enhancing effect on [3H]thymidine incorporation by U937 cells. rIL-4 markedly induced expression of the Fc epsilon receptor (CD23) and the Leu-M3 antigen (CD14) on U937 cells. HL60 and THP-1 cells treated with rIL-4 also showed increased CD23 expression, but little change of CD14 antigen expression. CD23 induction required lower amounts of IL-4 than needed for T cell growth, indicating that CD23 induction on U937 will serve as a sensitive assay for human IL-4. rIL-4 reduced the steady state level of IL-1 beta mRNA in U937.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Noma T,Nakakubo H,Hama K,Honjo Tdoi
10.1016/0165-2478(89)90027-8subject
Has Abstractpub_date
1989-06-15 00:00:00pages
323-8issue
4eissn
0165-2478issn
1879-0542pii
0165-2478(89)90027-8journal_volume
21pub_type
杂志文章abstract::A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02550-3
更新日期:1996-06-01 00:00:00
abstract::Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.04.014
更新日期:2016-06-01 00:00:00
abstract::Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90125-t
更新日期:1991-04-01 00:00:00
abstract::Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.05.010
更新日期:2017-09-01 00:00:00
abstract::Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropher...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.04.011
更新日期:2016-06-01 00:00:00
abstract:AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.07.013
更新日期:2009-09-22 00:00:00
abstract::Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.08.011
更新日期:2017-10-01 00:00:00
abstract::A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)02696-5
更新日期:1997-03-01 00:00:00
abstract::The monoclonal antibody (mAb) UN2 was generated upon immunization of a Balb/c mouse with human thymocytes. mAb UN2 recognized an antigen expressed by a subpopulation of human thymocytes and peripheral blood lymphocytes. In thymus, mAb UN2 recognized cortical cells; its expression was higher on CD3bright than on CD3dim...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90035-3
更新日期:1994-09-01 00:00:00
abstract::Human Clq, a subcomponent of the first component of complement interacts with human fibronectin. Using ELISA methodology fixation of Clq to solid phase fibronectin, as well as fibronectin to solid phase Clq has been demonstrated. Cl in its native macromolecular form displays little reactivity for fibronectin, nor does...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90075-x
更新日期:1982-01-01 00:00:00
abstract::To investigate the in vivo role of complement component C5 it is common to compare the inflammatory response between C5-normal and C5-deficient inbred mice strains. Nevertheless, it should be expected that differences in the genetic backgrounds between those strains may affect several physiological parameters, complic...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.02.010
更新日期:2014-05-01 00:00:00
abstract::In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90095-x
更新日期:1981-04-01 00:00:00
abstract::RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While age...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.01.005
更新日期:2006-05-15 00:00:00
abstract::Humanized mouse models present an important tool for preclinical evaluation of new vaccines and therapeutics. Here we show the human variable repertoire of antibody sequences cloned from a previously described human immune system (HIS) mouse model that possesses functional human CD4+ T cells and B cells, namely HIS-CD...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.06.001
更新日期:2017-08-01 00:00:00
abstract::Applying 2 M KBr, membranes of Ehu were solubilized. By C3-affinity chromatography an activity could be isolated that inhibited the immune adherence reaction and C3b-dependent rosette formation. Since this material did not agglutinate EAC14oxy23b we termed it monovalent C3b receptor (mC3bR). PAGE and SDS-PAGE and stai...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90069-4
更新日期:1982-01-01 00:00:00
abstract::As a cytokine adjuvant, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been demonstrated to play central roles in the enhancement of the immune response and protection elicited by experimental vaccines. However, in our previous work, the co-administration of GM-CSF produced untoward effects on the immun...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.08.005
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.imlet.2017.12.008
更新日期:2018-02-01 00:00:00
abstract::In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90213-t
更新日期:1991-07-01 00:00:00
abstract::The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.03.001
更新日期:2009-04-27 00:00:00
abstract::In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90067-z
更新日期:1990-02-01 00:00:00
abstract::Phosphatidylinositol 3-kinase (PI3K) is critical player in cell proliferation and survival. The effects of LY294002 and wortmannin, inhibitors of PI3K, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in lipoploysaccharide (LPS)-induced Raw 264.7 cells were investigated. Significan...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.12.007
更新日期:2005-06-15 00:00:00
abstract:UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.03.018
更新日期:2004-05-15 00:00:00
abstract::The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradati...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90145-7
更新日期:1994-07-01 00:00:00
abstract::Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which lim...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.10.011
更新日期:2015-12-01 00:00:00
abstract::Isolation of recombinant antibodies from antibody libraries is commonly performed by different molecular display formats including phage display and ribosome display or different cell-surface display formats. We describe a new method which allows the selection of Escherichia coli cells producing the required single ch...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.02.005
更新日期:2013-03-01 00:00:00
abstract::The aim of this work was to raise allotype specific monoclonal antibodies to human CD45, with the long-term objective of producing a reagent which could be used to prolong graft survival in renal transplantation through removal of passenger leukocytes from the graft. At present there are no anti-CD45 monoclonal antibo...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00056-5
更新日期:1999-06-01 00:00:00
abstract::The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90087-7
更新日期:1990-08-01 00:00:00
abstract::We have described a monoclonal antibody with specificity for permeability-altered drug-resistant cells. This gamma G2b antibody was characterized by antibody-mediated complement-dependent cytotoxicity and by immunofluorescence analysis using a flow cytometer-cell sorter. Further experiments with the flow cytometer sho...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90084-0
更新日期:1982-07-01 00:00:00
abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.03.003
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes. Therefore, the purpose ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.04.005
更新日期:2013-04-01 00:00:00