J chain-positive cells in bursectomized chicks.

abstract：:In transplant rejection, graft versus host or autoimmune diseases T cells are mediating the pathophysiological processes. Compared to unspecific pharmacological immune suppression specific inhibition of those T cells, that are involved in the disease, would be an alternative and attractive approach. T cells are activa...

journal_title：Immunology letters

authors： Neumann F,Sturm C,Hülsmeyer M,Dauth N,Guillaume P,Luescher IF,Pfreundschuh M,Held G

更新日期：2009-08-15 00:00:00

abstract：:Humanized mouse models present an important tool for preclinical evaluation of new vaccines and therapeutics. Here we show the human variable repertoire of antibody sequences cloned from a previously described human immune system (HIS) mouse model that possesses functional human CD4+ T cells and B cells, namely HIS-CD...

journal_title：Immunology letters

authors： Nogueira RT,Sahi V,Huang J,Tsuji M

更新日期：2017-08-01 00:00:00

abstract：:Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent ...

journal_title：Immunology letters

authors： Das MR,Gridley DS,Kettering JD

更新日期：1991-09-01 00:00:00

abstract：:Pathogens in general and pathogenic viruses in particular have evolved a myriad of mechanisms to escape the immune response of mammalian species. Viruses that cause acute disease tend to bear characteristics that make them very contagious, as survival does not derive from chronicity of infection, but spread of disease...

journal_title：Immunology letters

authors： Toka FN,Golde WT

更新日期：2013-05-01 00:00:00

abstract：:The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...

journal_title：Immunology letters

authors： Bharti AC,Singh SM

更新日期：2000-04-03 00:00:00

abstract：:Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan b...

journal_title：Immunology letters

authors： Gostner JM,Raggl E,Becker K,Überall F,Schennach H,Pease JE,Fuchs D

更新日期：2015-12-01 00:00:00

abstract：:The effect of oligosaccharides and C-terminal lysine residues on the thermal stability of a recombinant IgG(1) monoclonal antibody was investigated using differential scanning calorimetry (DSC). The C-terminal lysine did not appear to affect the thermal stability of this IgG(1) molecule. However, oligosaccharides, whi...

journal_title：Immunology letters

authors： Liu H,Bulseco GG,Sun J

更新日期：2006-08-15 00:00:00

abstract：:RASI-1 is a novel matrix metalloproteinase which we isolated from an expression cDNA library representing the mRNA of an inflamed synovium obtained from a patient with rheumatoid arthritis (RA). To investigate the involvement of RASI-1 in the pathology of RA, we examined synovial specimens from RA patients with antibo...

journal_title：Immunology letters

authors： Kolb C,Mauch S,Peter HH,Krawinkel U,Sedlacek R

更新日期：1997-06-01 00:00:00

abstract：:Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...

journal_title：Immunology letters

authors： Hernández M,Beltrán C,García E,Fragoso G,Gevorkian G,Fleury A,Parkhouse M,Harrison L,Sotelo J,Sciutto E

更新日期：2000-01-10 00:00:00

abstract：:Two chicken monoclonal antibodies (MAbs), HU/Ch2-7 and HU/Ch6-1, against heterophil Hanganutziu-Deicher (HD) antigens with N-glycolylneuraminic acid (NeuGc) at a terminal carbohydrate were established by cell fusions using chicken B cell lines lacking thymidine kinase and spleen cells from chickens immunized with II3N...

journal_title：Immunology letters

authors： Asaoka H,Nishinaka S,Wakamiya N,Matsuda H,Murata M

更新日期：1992-03-01 00:00:00

abstract：:The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Løac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention,...

journal_title：Immunology letters

authors： Norazmi MN,Suarn S

更新日期：1994-12-01 00:00:00

abstract：:It has been previously shown that normal human peripheral blood mononuclear cells produce a soluble factor(s) that causes selective inhibition of collagen production by cultured human diploid fibroblasts, and that stimulation of the mononuclear cells by appropriate mitogens greatly enhances its production. Because of ...

journal_title：Immunology letters

authors： Jimenez SA,Rosenbloom J

更新日期：1985-01-01 00:00:00

abstract：:When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...

journal_title：Immunology letters

authors： Malbec O,Daëron M

更新日期：2012-03-30 00:00:00

abstract：:In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...

journal_title：Immunology letters

authors： Górski A,Wasik M,Stepień-Sopniewska B,Glapiński T

更新日期：1991-05-01 00:00:00

abstract：:Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl-->up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines incr...

journal_title：Immunology letters

authors： Watanabe M,Tomiyama-Miyaji C,Kainuma E,Inoue M,Kuwano Y,Ren H,Shen J,Abo T

更新日期：2008-01-15 00:00:00

abstract：:Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...

journal_title：Immunology letters

authors： Rossi GA,Peri C,Raynal ME,Defilippi AC,Risso FM,Schenone G,Pallestrini E,Melioli G

更新日期：2003-03-03 00:00:00

abstract：:During a pathogenic infection, an inflammatory process is triggered in which several inflammatory mediators, such as cytokines, chemokines, growth factors, complement system components, nitric oxide, and others induce integrity alteration on the endothelial barrier. Chemokines are responsible for regulating leukocyte ...

journal_title：Immunology letters

authors： Cipitelli MDC,Amâncio Paiva I,Badolato-Corrêa J,de-Oliveira-Pinto LM

更新日期：2019-08-01 00:00:00

abstract：:Oral vaccine responsiveness is often lower in children from less developed countries. Childhood malnutrition may be associated with poor immune response to oral vaccines. The present study was designed to investigate whether protein energy malnutrition (PEM) impairs B cell immunity and ultimately reduces oral vaccine ...

journal_title：Immunology letters

authors： Rho S,Kim H,Shim SH,Lee SY,Kim MJ,Yang BG,Jang MH,Han BW,Song MK,Czerkinsky C,Kim JO

更新日期：2017-10-01 00:00:00

abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...

journal_title：Immunology letters

authors： Lanchbury JS

更新日期：1991-07-01 00:00:00

abstract：:A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...

journal_title：Immunology letters

authors： Buseyne F,Stevanovic S,Rammensee HG,Rivière Y

更新日期：1997-03-01 00:00:00

abstract：:Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, an...

journal_title：Immunology letters

authors： McCullough KC,Pullen L,Parkinson D

更新日期：1992-01-01 00:00:00

abstract：:The human immune system is a complex machinery involving numerous proteins. Proteins located at the cell surface of immune cells are of particular relevance due not only to their participation in the network of interactions that regulate the immune response but also to their potential as excellent targets for diagnost...

journal_title：Immunology letters

authors： Díaz-Ramos MC,Engel P,Bastos R

更新日期：2011-01-30 00:00:00

abstract：:Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors. Co-aggregation of receptors is essential because BCR activated kinases must phosphorylate FcgammaRIIB to recruit SHIP and mediate inhibitory signals. Pre-B cells als...

journal_title：Immunology letters

authors： Brauweiler AM,Cambier JC

更新日期：2004-03-29 00:00:00

abstract：:Sepsis is an abnormal immune response to infection characterized by an overwhelming systemic inflammation and cell death. Non-apoptotic cell death pertaining to pyroptosis, necroptosis and autophagy contribute to sepsis pathogenesis apart from classical apoptotic cell death. The objective of the current study is to in...

journal_title：Immunology letters

authors： Mallarpu CS,Ponnana M,Prasad S,Singarapu M,Kim J,Haririparsa N,Bratic N,Brar H,Chelluri LK,Madiraju C

更新日期：2021-01-03 00:00:00

abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...

journal_title：Immunology letters

authors： Inuzuka S,Koga S,Nishikido M,Miyata Y,Kanda S,Shimokawa I,Tanaka M,Saito Y,Kanetake H

更新日期：2002-09-02 00:00:00

abstract：:CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a 'primary' cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-92...

journal_title：Immunology letters

authors： Komatsu Y,Nawa Y,Marbrook J

更新日期：1982-01-01 00:00:00

abstract：:In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...

journal_title：Immunology letters

authors： Bradley JA

更新日期：1991-07-01 00:00:00

abstract：:Interleukin 1 beta (IL1 beta) is an inducible polypeptide with many roles in host defence and homoeostasis. It has also been implicated as a mediator of infectious, inflammatory and autoimmune diseases, and the kinetics of its production are relevant to an understanding of the pathogenesis of these conditions. We repo...

journal_title：Immunology letters

authors： di Giovine FS,Symons JA,Duff GW

更新日期：1991-08-01 00:00:00

abstract：:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...

journal_title：Immunology letters

authors： Friedrich U,Scheidtmann KH,Walter G

更新日期：1986-04-01 00:00:00

abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

journal_title：Immunology letters

authors： Pappalardo E,Zingale LC,Cicardi M

更新日期：2003-05-01 00:00:00