Abstract：
:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil interaction. Pre-treatment of neutrophils with cytochalasin B but not sodium fluoride inhibited factor secretion. The factor was sensitive to trypsin and heat treatment. Ultrafiltration experiments showed that it has a molecular weight between 10,000 and 30,000 daltons. Its biologic role may be that of a molecular mediator for the recruitment of resting neutrophils so as to amplify the immunological and inflammatory response.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Seow WK,Thong YHdoi
10.1016/0165-2478(87)90086-1subject
Has Abstractpub_date
1987-01-01 00:00:00pages
95-101issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(87)90086-1journal_volume
14pub_type
杂志文章abstract：:E1, E3-deleted, replication-deficient recombinant adenoviruses are widely studied as vectors for their capacity to transfer therapeutic genes in vivo. They can infect a wide variety of dividing and quiescent cells from different organs and possess a large packaging capacity. One of the major limitations in the use of ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00049-7
更新日期：1997-06-01 00:00:00
abstract：:In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90067-z
更新日期：1990-02-01 00:00:00
abstract：:In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.11.007
更新日期：2007-02-15 00:00:00
abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.12.008
更新日期：2008-03-15 00:00:00
abstract：:We studied isotype profiles of anti-HIV antibodies (Ab) in HIV-1-infected African patients with high viral loads and major B cell dysfunction. We focussed on IgG1, IgG3, and IgA as these classes and subclasses tend to support neutralizing functions against HIV. Total IgG1, IgG3 and IgA were detected in the plasma of b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.02.004
更新日期：2004-04-30 00:00:00
abstract：:CD103(+)CD11b(+) dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103(+)CD11b(+) DC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.05.012
更新日期：2016-08-01 00:00:00
abstract：:This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90046-x
更新日期：1985-01-01 00:00:00
abstract：:NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.02.009
更新日期：2020-05-01 00:00:00
abstract：:Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.014
更新日期：2016-06-01 00:00:00
abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00177-2
更新日期：2000-05-01 00:00:00
abstract：:Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (o...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2017.07.014
更新日期：2017-10-01 00:00:00
abstract：:To explore the genetic association of single nucleotide polymorphisms (SNPs) in the coding region of the NOTCH4, exon 3 C+1297T and exon 5 A+3063G, in a case-control analysis of 58 rheumatoid arthritis (RA) and 98 alopecia areata (AA) and 100 ethnically matched healthy subjects. NOTCH4 polymorphisms were genotyped by ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.01.002
更新日期：2013-02-01 00:00:00
abstract：:The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to establish the time-dependent relation between plasma cytokines interleukin (IL)-10, transforming growth factor (TGF)-beta1, ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.07.009
更新日期：2004-09-01 00:00:00
abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.017
更新日期：2014-12-01 00:00:00
abstract：:Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in mono...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02622-3
更新日期：1996-11-01 00:00:00
abstract：:The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(98)00153-9
更新日期：1999-03-01 00:00:00
abstract：:A TNF-like factor was purified from lipopolysaccharide (LPS) induced New Zealand white rabbit serum. The TNF-like factor was purified by DEAE-Sephacel, Sephacryl S-200, Mono-Q, CM-affi gel Blue, Superose 12 H/R preparative columns to the specific activity of 4 x 10(6) U/mg protein. The purified protein was 45 kDa in i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00134-x
更新日期：1998-02-01 00:00:00
abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.06.009
更新日期：2015-09-01 00:00:00
abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90183-x
更新日期：1994-05-01 00:00:00
abstract：:Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tes...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90151-8
更新日期：1985-01-01 00:00:00
abstract：:Small soluble IgG aggregates of defined size were prepared from pooled human IgG by gel filtration chromatography, and examined by analytical ultracentrifugation. Three such fractions, dimer-rich, trimer-rich and 25S aggregate were used to inhibit IgG monomer binding in a study of the influence of aggregation in the b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90036-6
更新日期：1983-01-01 00:00:00
abstract：:In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.05.012
更新日期：2017-08-01 00:00:00
abstract：:We have recently generated CD4 clones from BALB/c mice immunized with a plasmid DNA containing the gene encoding for the catalytic domain of trans-sialidase, an important enzyme expressed on the surface of Trypanosoma cruzi trypomastigotes. These clones allowed us to study in vitro the interaction between T cells and ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00205-4
更新日期：2000-07-03 00:00:00
abstract：:Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4+CD25bri regulatory ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.009
更新日期：2017-01-01 00:00:00
abstract：:Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.05.013
更新日期：2014-09-01 00:00:00
abstract：:Luminol-dependent chemiluminescence (CL) triggered by mineral dust in rabbit alveolar macrophages depended on superoxide production as revealed by inhibition by superoxide dismutase and ferricytochrome c. The contribution of superoxide changed in the course of CL peak between 80-20%. The effects of ferricytochrome c w...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90137-4
更新日期：1987-08-01 00:00:00
abstract：:In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90095-x
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.01.007
更新日期：2020-04-01 00:00:00
abstract：:The cytotoxicity of natural killer (NK) and lymphokine activated killer (LAK) cells against two human bladder tumor cell lines (BT-A and BT-B) was investigated using a fluorometric assay by labeling tumor cell DNA with Hoechst dye No. 33342. Our results demonstrate that BT-A and BT-B cells have low sensitivity to the ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90150-9
更新日期：1991-03-01 00:00:00
abstract：:To investigate the in vivo role of complement component C5 it is common to compare the inflammatory response between C5-normal and C5-deficient inbred mice strains. Nevertheless, it should be expected that differences in the genetic backgrounds between those strains may affect several physiological parameters, complic...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.02.010
更新日期：2014-05-01 00:00:00
