Abstract：
:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90% re-polarization. Perfusion with interleukin-2 resulted in appearance of frequent rhythm patterns followed by smooth transient fragments of paroxysmal tachyarrhythmia pacing into normal rhythms. In the presence of interleukin-2, stretching of the tissue by 1.7 mN led to appearance of abnormal bio-electrical activity, predominantly in the lengthening of the duration of action potential at the levels of 90% re-polarization. Close observation of both interleukin-2 induced action potential duration to 90% of re-polarization, hump-like depolarization and stretch induced hump-like alteration, indicate existence of a link between the interleukin-2 and stretch induced mechanisms.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Aksyonov A,Mitrokhin VM,Mladenov MIdoi
10.1016/j.imlet.2015.06.009subject
Has Abstractpub_date
2015-09-01 00:00:00pages
23-8issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(15)00115-7journal_volume
167pub_type
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